- Comprehensive information about Lomotil and allied drugs is under the article Diphenoxylate.
|Diphenoxylate||mu opiate receptor agonist|
|Atropine||muscarinic acetylcholine receptors antagonist|
Its active ingredients are diphenoxylate and atropine. Diphenoxylate is anti-diarrheal and atropine is anticholinergic. A subtherapeutic amount of atropine sulfate is present to discourage deliberate overdosage. Atropine has no anti-diarrheal properties, but will cause tachycardia when overused. The medication diphenoxylate works by slowing down the movement of the intestines. In some cases Lomotil has been shown to ease symptoms of opiate/opioid withdrawal.
Other trade names for the same therapeutic combination are Lofene, Logen, Lomanate and Lonox, among others. In other countries, Lomotil may have other names.
Absolute contraindications for Lomotil are:
- Allergy to diphenoxylate or atropine
- Presence of jaundice
- Diarrhea associated with pseudomembranous enterocolitis, diarrhea caused by antibiotic treatment, or diarrhea caused by enterotoxin-producing bacteria.
Interactions with other drugs:
- Sedatives (e.g. Ambien, Sonata)
- Opioid analgesics
- Antidepressants (e.g. Elavil, Prozac)
- Monoamine oxidase inhibitors (e.g. Nardil, Parnate)
The drug combination is generally safe in short-term use and with recommended dosage. In doses used for the treatment of diarrhea, whether acute or chronic, diphenoxylate has not produced addiction.
Lomotil may cause several side-effects, such as dry mouth, headache, constipation and blurred vision. Since it may also cause drowsiness or dizziness, Lomotil should not be used by motorists, operators of hazardous machinery, etc. It is not recommended for children under two years of age.
Lomotil may cause serious health problems when overdosed. Signs and symptoms of adverse effects may include any or several of the following: convulsions, respiratory depression (slow or stopped breathing), dilated eye pupils, nystagmus (rapid side-to-side eye movements), erythema (flushed skin), gastrointestinal constipation, nausea, vomiting, paralytic ileus, tachycardia (rapid pulse), drowsiness and hallucinations. Symptoms of toxicity may take up to 12 hours to appear.
Treatment of Lomotil overdose must be initiated immediately after diagnosis and may include the following: ingestion of activated charcoal, laxative and a counteracting medication (narcotic antagonist).
- DEA, Title 21, Section 829
- . Retrieved 14 February 2017.. UpToDate