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David Gorski

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David Henry Gorski
NationalityAmerican
Alma materCase Western Reserve University
University of Michigan
Scientific career
FieldsOncology
Surgery
InstitutionsWayne State University School of Medicine
Barbara Ann Karmanos Cancer Institute
Doctoral advisorKenneth Walsh

David H. Gorski is an American surgical oncologist, Professor of surgery at Wayne State University School of Medicine,[1] and a surgical oncologist at the Barbara Ann Karmanos Cancer Institute, specializing in breast cancer surgery.[2] He is a critic of alternative medicine and the anti-vaccination movement. He is the author of a blog, Respectful Insolence,[3] and is the managing editor of the website Science-Based Medicine.[4][5]

Early life

Gorski received his M.D. from the University of Michigan in 1988. He then completed his residency in general surgery at the University Hospitals of Cleveland, taking time off to acquire a Ph.D. in cellular physiology from Case Western Reserve University in 1994 with a dissertation entitled: "Homeobox Gene Expression and Regulation in Vascular Myocytes".[6] After completing his residency, he completed a research fellowship in surgical oncology at the University of Chicago.[1][7]

Career

Gorski was previously Assistant Professor of Surgery at the Cancer Institute of New Jersey and the UMDNJ-Robert Wood Johnson Medical School in New Brunswick, NJ, as well as a member of the Joint Graduate Program in Cell & Developmental Biology at Rutgers University in Piscataway, NJ and The Cancer Institute of New Jersey.[8] He became the Medical Director of the Alexander J. Walt Comprehensive Breast Center at the Barbara Ann Karmanos Cancer Institute in 2010[9] and was appointed co-director of the Michigan Breast Oncology Quality Initiative in 2013.[10] Gorski is a Professor of Surgery and Oncology at the Wayne State University School of Medicine,[1] whose laboratory conducts research on transcriptional regulation of vascular endothelial cell phenotype, as well as the role of metabotropic glutamate receptors in breast cancer.[1] He is the cancer liaison physician for the American College of Surgeons Committee on Cancer,[11] the founder of the Institute for Science in Medicine[12] and a member of the American Society of Clinical Oncology.[13]

In 2007 Gorski received the Advanced Clinical Research Award in Breast Cancer from the American Society of Clinical Oncology.[14] Gorski was also awarded research grants by The Breast Cancer Research Foundation in 2008, 2009, and 2010.[13]

Research

Gorski's article, "Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation", characterizing the effects of angiogenesis inhibitors on the effectiveness of anti-tumor therapies has been cited over 900 times according to PubMed.[15][16] This research has been used in anti-tumor therapeutic research, including an observation that angiogenesis inhibitors enhanced the therapeutic effects of ionizing radiation "by preventing repair of radiation damage to endothelial cells,"[17] and in determining the potential of combinational therapies to allow reduction of the dosages required in toxic conventional treatments[18] while sustaining tumor regression when combined with specific antibodies and radiative therapies.[19]

Gorski's work with Helena Mauceri and others, published in Nature as "Combined effects of angiostatin and ionizing radiation in antitumour therapy" studied the "combined effects of angiostatin" (a protein occurring in several animal species) "and ionizing radiation in anti-tumor therapy"[20] led to investigation into the selective destruction of tumor cells, which according to a study by Gregg L. Semenza (citing Mauceri and others), "are more hypoxic than normal cells," allowing for "tumor cells to be killed without major systemic side effects."[21]

His article with Yun Chen "Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5" investigated into the use of microRNA to regulate angiogenesis[22] led to research by Jason E. Fish's group at the University of California, San Francisco, into the use of microRNA to regulate blood vessel development, and thus limiting tumor growth. Citing Chen and Gorski's research, Fish wrote that "several broadly expressed microRNAs regulate in vitro endothelial cell behavior, including proliferation, migration, and the ability to form capillary networks", and sought to describe the in vivo functionality of a specific set of microRNAs and their targets; the group was able to isolate a particular microRNA (miR-126) as the most highly enriched in endothelial cells.[23]

Skepticism of CAM

One person standing at a podium and three people sitting at a table with microphones in front of them
Skeptics Steven Novella, Harriet Hall, David Gorski, and Rachael Dunlop on a panel at The Amaz!ng Meeting 2012

Gorski is an outspoken skeptic of complementary and alternative medicine (CAM). In 2004, Gorski, under the pen name "Orac”, began writing a blog entitled Respectful Insolence at Blogspot. In 2006, Respectful Insolence was moved to the ScienceBlogs website.[24][25] In 2008 Gorski used his real name when he started blogging at Science-Based Medicine (he continues to use 'Orac' for Respectful Insolence). He is currently their managing editor, and has posted on issues at the intersection of medicine and pseudoscience, including the anti-vaccination movement, alternative therapies, and cancer research and treatment.[26][27] According to Gorski, in 2010 members of the anti-vaccine blog Age of Autism wrote to the board of directors at Wayne State University and asked that he be prevented from blogging.[28] He has contributed considerable parts of the James Randi Education Foundation's series of EBooks, the Science Based Medicine Guides.[29] He is also a fellow of the Committee for Skeptical Inquiry.[30]

Gorski was a speaker at The Amaz!ng Meeting in 2009, 2010, 2012 and 2013.[31][32] He has also participated in numerous panels on alternative medicine.[33][34][35] He called attention to a paper by John P. A. Ioannidis on problems with published research.[36]

Gorski has commented on the increasing infiltration of pseudoscience in the medical field with the use of alternative therapies,[37][38] the use of acupuncture for treatment of soldiers,[39] "detox" cleanses,[40] and dietary treatment of autism.[41]

He advocates for openness of the results of clinical trials[42] and the use of only evidence-based medicine to treat diseases. He has been critical of Senator Tom Harkin's support of the National Center for Complementary and Alternative Medicine (NCCAM).[27] He has criticized the National Institutes of Health (NIH) and NCCAM for funding and publishing research on, “treatment modalities that are inherently unscientific, being as they are based on prescientific or demonstrably incorrect understandings of human physiology and disease”,[43][44] and has commented on the ethics, methods, and results of the study of alternative medicine.[45]

Gorski has spoken out against the popularization of what he describes as pseudoscience by the media and celebrities such as Oprah Winfrey,[46] Bill Maher,[47] Ann Coulter,[48] and the Huffington Post.[49] In June 2013 Gorski said he supported healthcare professionals speaking out against poor medical practices and the sale of "dubious therapies."[50]

Gorski was interviewed by WPRR in 2012.[51] He called the co-sponsorship of Integrative Medicine Day by the American Medical Students Association “an infiltration of quackademic medicine” and was described by the pro-CAM science writer David H. Freedman as "one of the more prickly anti-alternative-medicine warriors."[52]

In 2014, Gorski and fellow skeptic Steven Novella published an article denouncing clinical trials of integrative medicine and arguing that such trials "degrade the scientific basis of medicine" by, according to Calcutta's The Telegraph, "portraying formulations whose basis rests on pre-scientific thinking as though they were supported by science."[53][54]

Views on other medical issues

Gorski has been vocally critical of right-to-try laws, which expand access to experimental drugs for terminally ill patients.[55] He has also voiced skepticism of the theory that atavism played a role in the evolution of cancer.[56]

Publications

  • Speyer, Cecilia L.; Nassar, Mahdy A.; Hachem, Ali H.; Bukhsh, Miriam A.; Jafry, Waris S.; Khansa, Rafa M.; Gorski, David H. (4 May 2016). "Riluzole mediates anti-tumor properties in breast cancer cells independent of metabotropic glutamate receptor-1". Breast Cancer Research and Treatment. 157 (2): 217–228. doi:10.1007/s10549-016-3816-x. PMID 27146584.
  • Welch HG, Gorski DH, Albertsen PC (2015). "Trends in Metastatic Breast and Prostate Cancer—Lessons in Cancer Dynamics". N Engl J Med. 373 (18): 1685–1687. doi:10.1056/NEJMp1510443. PMID 26510017.
  • Gorski D. H. (2014). "Integrative oncology: really the best of both worlds?". Nat Rev Cancer. 14 (10): 692–700. doi:10.1038/nrc3822. PMID 25230880.

References

  1. ^ a b c d "David H. Gorski". Cancer Biology Graduate Program. Wayne State University School of Medicine. 2013. Retrieved 14 June 2013.
  2. ^ "David Gorski M.D., Ph.D." Physician Details. Barbara Ann Karmanos Cancer Institute, Wayne State University. 2013. Retrieved 17 May 2013.
  3. ^ Gorski, David. "Respectful Insolence". ScienceBlogs. Retrieved 10 June 2013.
  4. ^ Szabo, Lisa (18 June 2013). "How to guard against a quack". USA Today. Retrieved 22 June 2013.
  5. ^ "David H. Gorski, MD, PhD – Managing Editor". Science-Based Medicine. Retrieved 10 June 2013.
  6. ^ "David Gorski, M.D." Faculty. Department of Surgery / Detroit Medical Center, Wayne State University. 2005. Retrieved 20 March 2013.
  7. ^ Bepler, Gerold; Karmanos Cancer Institute (1 February 2011). "Barbara Ann Karmanos Cancer Center names Dr. David Gorski leader of breast multidisciplinary team". PR Newswire. Retrieved 18 June 2013. {{cite journal}}: Cite journal requires |journal= (help)CS1 maint: postscript (link)
  8. ^ "Breast Cancer Program". Barbara Ann Kamanos Cancer Institute, Wayne State University. 2013. Retrieved 17 May 2013.
  9. ^ "Karmanos Cancer Center's Dr. David Gorski appointed program co-director of Michigan Breast Oncology Quality Initiative". Karmanos Cancer Institute. Retrieved 2 August 2013.
  10. ^ "Dr. David Gorski appointed Cancer Liaison Physician for Karmanos". Prognosis E-News. Wayne State University School of Medicine. 7 January 2009. Retrieved 17 May 2013.
  11. ^ "David H. Gorski, MD, PhD". ISM Fellows. Institute for Science in Medicine. 2011. Retrieved 13 June 2013.
  12. ^ a b "2007 - 2008 Grantees" (PDF). Pink Press. The Breast Cancer Research Foundation. Winter 2008. p. 8. Archived from the original (PDF) on 2013-09-11.
    "2008 - 2009 Grantees" (PDF). Pink Press. The Breast Cancer Research Foundation. Winter 2009. p. 9. Archived from the original (PDF) on 2013-09-11.
    "2009 - 2010 Grantees" (PDF). Pink Press. The Breast Cancer Research Foundation. Winter 2010. p. 8. Archived from the original (PDF) on 2013-09-11.
  13. ^ Fisher, Michele; The Cancer Institute of New Jersey (11 June 2007). "New Jersey surgical oncologist receives prestigious award at international conference". University of Medicine and Dentistry of New Jersey. Archived from the original on 5 February 2013. Retrieved 14 June 2013. CINJ scientist receives a near half-million dollars for future breast cancer research. {{cite journal}}: Cite journal requires |journal= (help)CS1 maint: postscript (link)
  14. ^ Gorski, David H.; Beckett, Michael A.; Jaskowiak, Nora T.; Calvin, Douglas P.; et al. (15 July 1999). "Blockade of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation". Cancer Research. 59 (14): 3374–3378. PMID 10416597. Retrieved 21 June 2013.
  15. ^ Related Citations for PubMed (Select 10416597), PubMed, retrieved 28 June 2013
  16. ^ Kerbel, Robert; Folkman, Judah (October 2002). "Clinical translation of angiogenesis inhibitors". Nature Reviews Cancer. 2 (10): 727–739. doi:10.1038/nrc905. PMID 12360276. Retrieved 18 June 2013.
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  18. ^ Klement, Giannoula; Baruchel, Sylvain; Rak, Janusz; Man, Shan; et al. (15 April 2000). "Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity". Journal of Clinical Investigation. 105 (8): R15–R24. doi:10.1172/JCI8829. PMC 517491.
  19. ^ Mauceri, Helena J.; Hanna, Nader N.; Beckett, Michael A.; Gorski, David H.; et al. (16 July 1998). "Combined effects of angiostatin and ionizing radiation in antitumour therapy". Nature. 394 (6690): 287–291. doi:10.1038/28412. PMID 9685160. Retrieved 20 June 2013.
  20. ^ Semenza, Gregg L. (1999). "Regulation of Mammalian O2 Homeostasis by Hypoxia-Inducible Factor 1". Annual Review of Cell and Developmental Biology. 15 (1): 551–578. doi:10.1146/annurev.cellbio.15.1.551. PMID 10611972. Retrieved 20 June 2013.
  21. ^ Chen, Yun; Gorski, David H. (1 February 2008). "Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5". Blood. 111 (3): 1217–1226. doi:10.1182/blood-2007-07-104133. PMC 2214763.
  22. ^ Fish, Jason E.; Santoro, Massimo M.; Morton, Sarah U.; Yu, Sangho; et al. (12 August 2008). "miR-126 Regulates Angiogenic Signaling and Vascular Integrity". Developmental Cell. 15 (2): 272–284. doi:10.1016/j.devcel.2008.07.008. PMC 2604134. Retrieved 22 June 2013.
  23. ^ Bremner, Doug (19 September 2008). "Blogging doctors rock on!". The Huffington Post. Retrieved 24 June 2013.{{cite web}}: CS1 maint: postscript (link)
  24. ^ Gorski, David. "Respectful Insolence". ScienceBlogs. Retrieved 20 June 2013.
  25. ^ Jones, Val (4 June 2009), Kevin Pho (ed.), "Hostility Towards Scientists and Jenny McCarthy's Latest Video", KevinMD.com, MedPage Today, retrieved 25 June 2013.
  26. ^ a b Specter, Michael (29 October 2009). Denialism: How Irrational Thinking Harms the Planet and Threatens Our Lives. Penguin Group US. ISBN 978-1-101-15102-0. Retrieved 21 June 2013.
  27. ^ Gorski, David H. (18 June 2010). "The price of opposing medical pseudoscience". Science-Based Medicine. Retrieved 14 June 2013. {{cite web}}: Italic or bold markup not allowed in: |publisher= (help)
  28. ^ JREF Staff. "JREF publishes three volumes on science-based medicine". James Randi Education Foundation. Retrieved 28 June 2013.
    "JREF publishes three more science-based medicine volumes". James Randi Education Foundation. Retrieved 28 June 2013.
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  29. ^ . (2009). "CSI Fellows and Staff". Committee for Skeptical Inquiry. Retrieved 2 August 2013. {{cite web}}: |author= has numeric name (help)
  30. ^ . (2013). "The Amaz!ing Meeting 2013: Schedule". The Amza!ing Meeting website. James Randi Education Foundation. Retrieved 24 June 2013. {{cite web}}: |author= has numeric name (help)
  31. ^ Novella, Steven (6 March 2009). "Science-Based Medicine Conference". Neurologica blog. New England Skeptical Society. Retrieved 24 June 2013.
    Wagg, Jeffrey (2010). "The Amaz!ng Meeting 8, 2010 Schedule". James Randi Educational Foundation. Retrieved 24 June 2013.{{cite journal}}: CS1 maint: postscript (link)
    . (23 August 2012). "Expert panel trashes "alternative medicine" concept". Consumer Health Digest (12–29). The National Council Against Health Fraud. Retrieved 25 June 2013. {{cite journal}}: |author= has numeric name (help)CS1 maint: postscript (link)
    . (2012). "The Amaz!ing Meeting 2012: Program". The Amaz!ng Meeting website. James Randi Education Foundation. Retrieved 24 June 2013. {{cite web}}: |author= has numeric name (help)
  32. ^ . (18 October 2010). "Drs. Ben Goldacre, David Gorski and Michael Shermer on the threat of pseudoscience". McGill University Faculty of Science. Retrieved 20 June 2013. {{cite web}}: |author= has numeric name (help)
  33. ^ "David Gorski — NECSS". Northeast Conference on Science and Skepticism website (NECSS). New England Skeptical Society and NYC Skeptics. Retrieved 24 June 2013.
  34. ^ . (2012). "Speakers". CSICon 2012 website. Committee for Skeptical Inquiry. Retrieved 24 June 2013. {{cite web}}: |author= has numeric name (help)
  35. ^ *Roach, Mary; Folger, Tim (4 October 2011). The Best American Science and Nature Writing 2011: The Best American Series. Houghton Mifflin Harcourt. pp. 123–124. ISBN 978-0-547-67846-7. Retrieved 21 June 2013.
  36. ^ Page, Leigh (12 June 2013), "What to do when a patient wants 'alternative' medicine", Medscape Business of Medicine, retrieved 25 June 2013.
  37. ^ Munger, Dave (2 September 2009). "Controls for acupuncture studies are improving. Their results are not. How are peer reviewers reacting?". Seed. Retrieved 27 June 2013.
  38. ^ Salzberg, Steven (15 February 2010), "Battlefield acupuncture: Pseudoscience for wounded troops", Forbes.com, retrieved 25 June 2013.
  39. ^ Lee, Linda (13 April 2012). "Bridal Hunger Games: Losing Weight in Time for the Wedding". The New York Times. Retrieved 25 June 2013.
  40. ^ Hansen, Lacy Jaye (7 December 2012), "The GAPS diet claims you can eat away autism. But can you really?", Diets in Review.com, retrieved 25 June 2013.
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  50. ^ Brayton, Ed (host) (14 August 2012). "Dr. David Gorski and Mike Farrell". Culture Wars Radio. WPRR, Public Reality Radio. Archived from the original (podcast) on 13 November 2012. Retrieved 16 June 2013.
  51. ^ Freedman, David H. (May–June 2012). "Doctors who care: Does alternative medicine work?". Utne Reader. Retrieved 24 June 2013.{{cite news}}: CS1 maint: postscript (link)
  52. ^ Gorski, David H.; Novella, Steven P. (Sep 2014). "Clinical trials of integrative medicine: testing whether magic works?". Trends in Molecular Medicine. 20 (9): 473–6. doi:10.1016/j.molmed.2014.06.007. PMID 25150944.
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  55. ^ Merali, Zeeya (2 October 2014). "Did Cancer Evolve to Protect Us?". Scientific American. Retrieved 31 January 2015.
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