FMO2

FMO2
Identifiers
Aliases	FMO2, FMO1B1, flavin containing monooxygenase 2, flavin containing dimethylaniline monoxygenase 2
External IDs	OMIM: 603955 MGI: 1916776 HomoloGene: 86882 GeneCards: FMO2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	171,212,686 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	162,726,295 bp
RNA expression pattern
	Top expressed in
	pericardium; ; right lung; ; lower lobe of lung; ; lactiferous duct; ; ascending aorta; ; vena cava; ; upper lobe of lung; ; upper lobe of left lung; ; abdominal fat; ; coronary artery;
	Top expressed in
	ascending aorta; ; right lung; ; left lung lobe; ; aortic valve; ; right lung lobe; ; pericardium; ; esophagus; ; kidney; ; mesothelium; ; olfactory epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; N,N-dimethylaniline monooxygenase activity; NADP binding; flavin adenine dinucleotide binding; monooxygenase activity;
Cellular component	organelle membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; intracellular membrane-bounded organelle;
Biological process	xenobiotic metabolic process; toxin metabolic process; NADPH oxidation; NADP metabolic process; oxygen metabolic process; organic acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	2327
	55990
	ENSG00000094963
	ENSMUSG00000040170
	Q99518
	Q8K2I3
	NM_001301347; NM_001460; NM_001365900
	NM_018881; NM_001360913; NM_001360914
	NP_001288276; NP_001451; NP_001352829
	NP_061369; NP_001347842; NP_001347843
	Wikidata
View/Edit Human	View/Edit Mouse

Dimethylaniline monooxygenase [N-oxide-forming] 2 is an enzyme that in humans is encoded by the FMO2 gene.^[5]^[6]^[7]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000094963 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040170 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dolphin CT, Shephard EA, Povey S, Smith RL, Phillips IR (Nov 1992). "Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family". Biochem J. 287. ( Pt 1): 261–7. PMC 1133153. PMID 1417778.
^ Dolphin CT, Beckett DJ, Janmohamed A, Cullingford TE, Smith RL, Shephard EA, Phillips IR (Dec 1998). "The flavin-containing monooxygenase 2 gene (FMO2) of humans, but not of other primates, encodes a truncated, nonfunctional protein". J Biol Chem. 273 (46): 30599–607. doi:10.1074/jbc.273.46.30599. PMID 9804831.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ "Entrez Gene: FMO2 flavin containing monooxygenase 2 (non-functional)".

v t e Oxidoreductases: dioxygenases, including steroid hydroxylases (EC 1.14)
1.14.11: 2-oxoglutarate	Prolyl hydroxylase HIF prolyl-hydroxylase EGLN1 EGLN2 EGLN3 P4HTM Lysyl hydroxylase AlkB ALKBH1 FTO
1.14.13: NADH or NADPH	Flavin-containing monooxygenase FMO1 FMO2 FMO3 FMO4 FMO5 Nitric oxide synthase NOS1 NOS2 NOS3 Cholesterol 7 alpha-hydroxylase Methane monooxygenase 3A4 14α-demethylase 24-hydroxycholesterol 7α-hydroxylase
1.14.14: reduced flavin or flavoprotein	19A1 2D6 2E1
1.14.15: reduced iron–sulfur protein	11B1 11B2 11A1
1.14.16: reduced pteridine (BH4 dependent)	Phenylalanine hydroxylase Tyrosine hydroxylase Tryptophan hydroxylase
1.14.17: reduced ascorbate	Dopamine beta-hydroxylase
1.14.18-19: other	Tyrosinase Stearoyl-CoA desaturase-1
1.14.99 - miscellaneous	Cyclooxygenase Heme oxygenase (HMOX1) Squalene monooxygenase 17A1 21A2 Ecdysone 20-monooxygenase Deoxyhypusine monooxygenase

References

Further reading