Glutamate carboxypeptidase

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Glutamate carboxypeptidase
EC number
CAS number 9074-87-7
IntEnz IntEnz view
ExPASy NiceZyme view
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Glutamate carboxypeptidase (EC, carboxypeptidase G, carboxypeptidase G1, carboxypeptidase G2, glutamyl carboxypeptidase, N-pteroyl-L-glutamate hydrolase) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction

Release of C-terminal glutamate residues from a wide range of N-acylating moieties, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups

This zinc enzyme is produced by pseudomonads, Flavobacterium sp. and Acinetobacter sp.

See also[edit]


  1. ^ Goldman, P.; Levy, C.C. (1967). "Carboxypeptidase G: purification and properties". Proc. Natl. Acad. Sci. USA. 58: 1299–1306. doi:10.1073/pnas.58.4.1299. PMC 223923Freely accessible. PMID 5237864. 
  2. ^ McCullogh, J.L.; Chabner, B.A.; Bertino, J.R. (1971). "Purification and properties of carboxypeptidase G1". J. Biol. Chem. 246: 7207–7213. PMID 5129727. 
  3. ^ Albrecht, A.M.; Boldizar, E.; Hutchinson, D.J. (1978). "Carboxypeptidase displaying differential velocity in hydrolysis of methotrexate, 5-methyltetrahydrofolic acid, and leucovorin". J. Bacteriol. 134: 506–513. PMC 222280Freely accessible. PMID 26657. 
  4. ^ Sherwood, R.F.; Melton, R.G.; Alwan, S.A. (1985). "Purification and properties of carboxypeptidase G2 from Pseudomonas sp. strain RS-16". Eur. J. Biochem. 148: 447–453. doi:10.1111/j.1432-1033.1985.tb08860.x. PMID 3838935. 

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