HLA-DOB

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HLA-DOB
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases HLA-DOB, DOB, HLA-DOB, major histocompatibility complex, class II, DO beta
External IDs MGI: 95925 HomoloGene: 1602 GeneCards: 3112
RNA expression pattern
PBB GE HLA-DOB 205671 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002120

NM_010389

RefSeq (protein)

NP_002111.1

n/a

Location (UCSC) Chr 6: 32.81 – 32.82 Mb Chr 17: 34.24 – 34.25 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

HLA class II histocompatibility antigen, DO beta chain is a protein that in humans is encoded by the HLA-DOB gene.[1]

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.[1]

References[edit]

Further reading[edit]