HLA-DOB

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HLA-DOB
Available structures
PDBHuman UniProt search: PDBe RCSB
Identifiers
AliasesHLA-DOB, DOB, major histocompatibility complex, class II, DO beta, HLA_DOB
External IDsMGI: 95925 HomoloGene: 1602 GeneCards: HLA-DOB
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for HLA-DOB
Genomic location for HLA-DOB
Band6p21.32Start32,812,763 bp[1]
End32,820,466 bp[1]
RNA expression pattern
PBB GE HLA-DOB 205671 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002120

NM_010389

RefSeq (protein)

NP_002111

n/a

Location (UCSC)Chr 6: 32.81 – 32.82 MbChr 17: 34.24 – 34.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

HLA class II histocompatibility antigen, DO beta chain is a protein that in humans is encoded by the HLA-DOB gene.[5]

HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail.[5]

References[edit]

  1. ^ a b c ENSG00000241910, ENSG00000243612, ENSG00000239457, ENSG00000241386, ENSG00000241106 GRCh38: Ensembl release 89: ENSG00000243496, ENSG00000241910, ENSG00000243612, ENSG00000239457, ENSG00000241386, ENSG00000241106 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041538 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:".
  4. ^ "Mouse PubMed Reference:".
  5. ^ a b "Entrez Gene: HLA-DOB major histocompatibility complex, class II, DO beta".

Further reading[edit]