Interstitial lung disease: Difference between revisions
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== Causes == |
== Causes == |
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Evan likes cougars. |
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[[Image:Alveolus diagram.svg|thumb|right|The alveoli]] |
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[[Image:Usual interstitial pneumonia (1).JPG|right|thumb|[[Micrograph]] of [[usual interstitial pneumonia]] (UIP). UIP is the most common pattern of [[idiopathic interstitial pneumonia]] (a type of interstitial lung disease) and usually represents [[idiopathic pulmonary fibrosis]]. [[H&E stain]]. [[Autopsy]] specimen.]] |
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ILD may be classified according to the cause.<ref name="pmid16891438">{{cite journal |author=Bourke SJ |title=Interstitial lung disease: progress and problems |journal=Postgrad Med J |volume=82 |issue=970 |pages=494–9 |year=2006 |month=August |pmid=16891438 |doi=10.1136/pgmj.2006.046417 |url=}}</ref> One method of classification is as follows# Inhaled substances#*Inorganic |
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#** [[Silicosis]] |
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#** [[Asbestosis]] |
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#** [[Berylliosis]] |
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#* Organic |
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#** [[Hypersensitivity pneumonitis]] |
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# Drug induced |
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#* [[Antibiotic]]s |
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#* [[Chemotherapy|Chemotherapeutic drugs]] |
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#* [[Antiarrhythmic agents]] |
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# Connective tissue disease |
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#* [[Systemic sclerosis]] |
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#* [[Dermatomyositis]] |
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#* [[Systemic lupus erythematosus]] |
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#* [[Rheumatoid arthritis]] |
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# Infection |
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#* [[Atypical pneumonia]] |
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#* [[Pneumocystis pneumonia (PCP)]] |
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#* [[Tuberculosis]] |
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# Idiopathic |
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#* [[Sarcoidosis]] |
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#* [[Idiopathic pulmonary fibrosis]] |
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#* [[Hamman-Rich syndrome]] |
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# Malignancy |
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#* Lymphangitic [[carcinoma]]tosis |
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== Investigation == |
== Investigation == |
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Revision as of 15:46, 31 October 2008
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| Interstitial lung disease | |
|---|---|
| Specialty | Pulmonology  |
Interstitial lung disease (ILD), also known as diffuse parenchymal lung disease (DPLD),[1] refers to a group of lung diseases affecting the interstitium of the lung:[2] alveolar epithelium, pulmonary capillary endothelium, basement membrane, perivascular and perilymphatic tissues. The term ILD is used to distinguish these diseases from obstructive airways diseases.
Most types of ILD involve fibrosis, but this is not essential; indeed fibrosis is often a later feature. The phrase "pulmonary fibrosis" is no longer considered a synonym, but the term is still used to denote ILD involving fibrosis.[3] The term is commonly combined with idiopathic in "idiopathic pulmonary fibrosis",[4][5][6] denoting fibrotic ILD that cannot be ascribed to a distinct primary cause.
Causes
Evan likes cougars.
Investigation
Investigation is tailored towards the symptoms and signs. Most patients have blood testing, chest x-ray, pulmonary function testing, and high resolution CT thorax.
A lung biopsy is required if the clinical history and imaging is not clearly suggestive of a specific diagnosis or malignancy cannot otherwise be ruled-out.
Treatment
ILD is not a single disease, but encompasses many different pathological processes. Hence treatment is different for each disease.
If a specific occupational exposure cause is found, the person should avoid that environment. If a drug cause is suspected, that drug should be discontinued.
Many idiopathic and connective tissue-based causes of ILD are treated with corticosteroids,[7] such as prednisolone. Some patients respond to immunosuppressant treatment. Patients with hypoxemia may be given supplemental oxygen.
References
- ^ King TE (2005). "Clinical advances in the diagnosis and therapy of the interstitial lung diseases". Am. J. Respir. Crit. Care Med. 172 (3): 268–79. doi:10.1164/rccm.200503-483OE. PMID 15879420.
{{cite journal}}: Unknown parameter|month=ignored (help) - ^ "Frequently Asked Questions About Interstitial Lung Disease - University of Chicago Medical Center".
- ^ Pulmonary+fibrosis at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ^ Online Mendelian Inheritance in Man (OMIM): PULMONARY FIBROSIS, IDIOPATHIC - 178500
- ^ "idiopathic pulmonary fibrosis" at Dorland's Medical Dictionary
- ^ Meltzer EB, Noble PW (2008). "Idiopathic pulmonary fibrosis". Orphanet J Rare Dis. 3: 8. doi:10.1186/1750-1172-3-8. PMC 2330030. PMID 18366757.
{{cite journal}}: CS1 maint: unflagged free DOI (link) - ^ "Interstitial lung disease: Treatments and drugs - MayoClinic.com".
External links
- . GPnotebook https://www.gpnotebook.co.uk/simplepage.cfm?ID=1476788304.
{{cite web}}: Missing or empty|title=(help) - Pulmonary+Fibrosis at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- MedlinePlus Overview pulmonaryfibrosis
- Dorothy P. and Richard P. Simmons Center for Interstitial Lung Diseases at University of Pittsburgh Medical Center
- Interstitial Lung Disease Program at University of Chicago
- PA-IPF - The Pennsylvania Idiopathic Pulmonary Fibrosis State Registry at University of Pittsburgh
- Interstitial Lung Disease Center at University of Cincinnati
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