Iron–sulfur cluster

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Structure of [Fe4S4(SMe)4]2−, a synthetic analogue of 4Fe-4S cofactors.[1]

Iron–sulfur clusters are molecular ensembles of iron and sulfide. They are most often discussed in the context of the biological role for iron-sulfur proteins, which are pervasive.[2] Many Fe-S clusters are known in the area of organometallic chemistry and as precursors to synthetic analogues of the biological clusters (see Figure).

Biomimetic clusters[edit]

The most well characterized clusters have the formula [Fe4S4(SR)4]2−, which are known for many R substituents, and with many cations. Many variations have been prepared including the incomplete cubanes [Fe3S4(SR)3]3−.[3]

Organometallic clusters[edit]

Organometallic Fe-S clusters include the sulfido carbonyls with the formula Fe2S2(CO)6, H2Fe3S(CO)9, and Fe3S2(CO)9. Compounds are also known that incorporate cyclopentadienyl ligands, such as (C5H5)4Fe4S4.[4]

Figure. Illustrative synthetic Fe-S clusters. From left to right: Fe3S2(CO)9, [Fe3S(CO)9]2−, (C5H5)4Fe4S4, and [Fe4S4Cl4]2−.

See also[edit]


  1. ^ Axel Kern, Christian Näther, Felix Studt, Felix Tuczek (2004). "Application of a Universal Force Field to Mixed Fe/Mo−S/Se Cubane and Heterocubane Clusters. 1. Substitution of Sulfur by Selenium in the Series [Fe4X4(YCH3)4]2-; X = S/Se and Y = S/Se". Inorg. Chem. 43: 5003–5010. doi:10.1021/ic030347d. 
  2. ^ S. J. Lippard, J. M. Berg “Principles of Bioinorganic Chemistry” University Science Books: Mill Valley, CA; 1994. ISBN 0-935702-73-3.
  3. ^ Rao, P. V.; Holm, R. H. (2004). "Synthetic Analogues of the Active Sites of Iron-Sulfur Proteins". Chem. Rev. 104: 527─559. doi:10.1021/Cr020615+. 
  4. ^ Ogino, H., Inomata, S., Tobita, H. (1998). "Abiological Iron-Sulfur Clusters". Chem. Rev. 98: 2093. doi:10.1021/cr940081f. 

External links[edit]