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Combination of
IsoniazidAnti-tuberculosis medication
Clinical data
Routes of
By mouth[1]
ATC code

Isoniazid/pyridoxine/sulfamethoxazole/trimethoprim (INH/B6/CTX) is a fixed dose combination medication for the prevention of opportunistic infections in HIV/AIDS.[1] It combines isoniazid, pyridoxine, sulfamethoxazole, and trimethoprim.[1] Specifically it is used to prevent tuberculosis, toxoplasmosis, pneumonia, malaria, and isosporiasis.[2][3] It is taken by mouth.[1]

Side effects may include trouble concentrating, numbness, vomiting, and rash.[2] Serious side effects may include liver problems.[2] Caution may be required in people with G6PD deficiency.[2] While it has not been well studied, use in pregnancy appears to be okay.[2]

It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.[1] A year of medication is estimated to cost about 15 USD in the developing world as of 2016.[3] While benefits include being able to take less pills, it is unclear if this version changes peoples adherence to treatment.[4] Other studies, however, have found fixed dose combinations to be useful for this purpose.[3]


  1. ^ a b c d e "WHO Model List of Essential Medicines (20th List)" (PDF). World Health Organization. March 2017. Retrieved 29 June 2017.
  2. ^ a b c d e "WHO Model List of Essential Medicines Application" (PDF). March 2011. Retrieved 29 June 2017.
  3. ^ a b c "WHO Model List of Essential Medicines Application" (PDF). Retrieved 13 December 2017.
  4. ^ "WHO application for the inclusion of INH/CTX/B6 FDC in the WHO Essential Medicines List" (PDF). Retrieved 13 December 2017.