PFKFB2

PFKFB2
Identifiers
Aliases	PFKFB2, PFK-2/FBPase-2, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
External IDs	OMIM: 171835; MGI: 107815; HomoloGene: 88554; GeneCards: PFKFB2; OMA:PFKFB2 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	207,081,024 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	130,656,990 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; oocyte; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; gastrocnemius muscle; ; rectum; ; apex of heart; ; duodenum; ; anterior pituitary; ; left ventricle;
	Top expressed in
	neural layer of retina; ; spermatocyte; ; islet of Langerhans; ; spermatid; ; superior frontal gyrus; ; pineal gland; ; lumbar subsegment of spinal cord; ; cerebellar cortex; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; kinase activity; protein binding; catalytic activity; fructose-2,6-bisphosphate 2-phosphatase activity; hydrolase activity; ATP binding; protein kinase binding; 6-phosphofructo-2-kinase activity; kinase binding;
Cellular component	cytoplasm; cytosol; nucleus; nucleoplasm;
Biological process	lactate metabolic process; glycolytic process; phosphorylation; fructose metabolic process; response to glucose; positive regulation of glucokinase activity; fructose 2,6-bisphosphate metabolic process; pyruvate metabolic process; glucose catabolic process; metabolism; positive regulation of insulin secretion; dephosphorylation; carbohydrate phosphorylation; positive regulation of glycolytic process;
	Sources:Amigo / QuickGO
Orthologs
	5208
	18640
	ENSG00000123836
	ENSMUSG00000026409
	O60825
	P70265
	NM_001018053; NM_006212
	NM_001162415; NM_001162416; NM_008825; NM_001368843
	NP_001018063; NP_006203
	NP_001155887; NP_001155888; NP_032851; NP_001355772
	Wikidata
View/Edit Human	View/Edit Mouse

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 is an enzyme that in humans is encoded by the PFKFB2 gene.^[5]

Template:PBB Summary

Interactions

PFKFB2 has been shown to interact with YWHAQ.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123836 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026409 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2".
^ Pozuelo Rubio, Mercedes; Peggie Mark; Wong Barry H C; Morrice Nick; MacKintosh Carol (Jul 2003). "14-3-3s regulate fructose-2,6-bisphosphate levels by binding to PKB-phosphorylated cardiac fructose-2,6-bisphosphate kinase/phosphatase". EMBO J. 22 (14). England: 3514–23. doi:10.1093/emboj/cdg363. ISSN 0261-4189. PMC 165633. PMID 12853467. {{cite journal}}: Cite has empty unknown parameters: |laydate=, |laysource=, and |laysummary= (help)

Interactions

References

Further reading