Pentalenic acid synthase
| Pentalenic acid synthase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.15.11 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Pentalenic acid synthase (EC 1.14.15.11, CYP105D7, sav7469 (gene)) is an enzyme with systematic name 1-deoxypentalenate,reduced ferredoxin:O2 oxidoreductase.[1] This enzyme catalyses the following chemical reaction
- 1-deoxypentalenate + reduced ferredoxin + O2 pentalenate + oxidized ferredoxin + H2O
Pentalenic acid synthase is a heme-thiolate enzyme (P-450).
References
- ^ Takamatsu, S.; Xu, L.H.; Fushinobu, S.; Shoun, H.; Komatsu, M.; Cane, D.E.; Ikeda, H. (2011). "Pentalenic acid is a shunt metabolite in the biosynthesis of the pentalenolactone family of metabolites: hydroxylation of 1-deoxypentalenic acid mediated by CYP105D7 (SAV_7469) of Streptomyces avermitilis". J. Antibiot. (Tokyo). 64 (1): 65–71. doi:10.1038/ja.2010.135. PMC 3030646. PMID 21081950.
External links
- Pentalenic+acid+synthase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)