People of the British Isles
|Research type||Science research project|
|Dr Bruce Winney|
|Faculty||Department of Oncology|
|Address||Old Road Campus Research Building|
|Campus||University of Oxford|
The first anatomically modern people to colonise Britain arrived in around 30,000 BC, as shown by the Red Lady of Paviland. During the last Ice Age, in particular in the Last Glacial Maximum, the British Isles was probably deserted but people began returning about 15,000 BC. Whether or not the British Isles were deserted during the last cold period around 10,000 BC, the Younger Dryas, is unclear but since then the genetic history of the isles has been continuous, with many immigrations from the continent of Europe since then as well as emigrations.
The project began in 2004 and is ongoing. It is being funded by the Wellcome Trust, and is currently on a second 5-year grant. Professor Sir Walter Bodmer leads the project.
So far PoBI has sampled around 4,500 blood samples. The project looks at around 600,000 single-nucleotide polymorphisms (genetic markers), including genes on Y-DNA and mtDNA, in collaboration with Professor Peter Donnelly at the Wellcome Trust Centre for Human Genetics. Volunteers are sampled from throughout the United Kingdom, with the requirement that they have four grandparents who were born in the same rural area. Blood samples (20ml each) are collected from each volunteer and the peripheral blood lymphocytes separated off and frozen down. DNA is prepared from the blood residue and is the DNA source for the analysis. Once this source of DNA has run out for an individual sample, a cell line can be created from the lymphocytes, which ensures a permanent source of DNA for further work. A number of normal phenotypes are now being collected for each volunteer, including 3D face photographs. Analysis of this data set is being undertaken in collaboration with Professor Josef Kittler of the University of Surrey.
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In an initial pilot project, genetic markers that were chosen included:
- HLA - human leukocyte antigen, the human major histocompatibility complex including HLA-A, HLA-B, HLA-C and HLA-DQ, HLA-DR
- the ABO blood group system
- the Y-chromosome
Further work, currently being written up, is based on about 600,000 autosomal markers.
Although based at the University of Oxford, samples have been collected by a number of other British universities, and data shared. An approximately equal number of male and female samples were collected, with a median age at collection of 65 years.
Most of southern, eastern and central England has shown a somewhat close genetic similarity with modern populations in the Low Countries, Germany and Denmark, which has been interpreted as representing a major contribution by peoples originally from Germany or Denmark such as the Angles, Saxons, Jutes, Frisians, Franks, later Danes and the previous Belgae Celts who had inhabited the same areas of Britain, or prior immigrants from before the aforementioned peoples arrived while the populations of areas such as Wales and southwestern England are closer to populations of modern-day western France  "'We might be seeing the result of Anglo-Saxon invasions pushing other peoples down into Cornwall or Wales,' he suggests. 'Or we might be seeing how Britain was recolonised after the ice ages. The West of our islands may have been peopled by movement up the coastal areas from Atlantic-facing Europe, whilst the southeast was influenced by pre-Anglo-Saxon movements from the area that now spans Denmark to Belgium. These patterns may then have been reinforced by the Anglo-Saxon invasions much later.'" 
- Winney, B. J., Boumertit, A., Day, T., Davison, D., Echeta, C., Evseeva, I., et al. (2012). People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population. European journal of human genetics : EJHG, 20(2), 203–210. doi:10.1038/ejhg.2011.127
- Keeling, Judith 2013 "What Makes the British?" in Oxford Today Vol.25 n.2, p.27-8
- Dr Bruce Winny, Oxford U, http://www.ox.ac.uk/media/news_stories/2012/120703.html