SNX17

From Wikipedia, the free encyclopedia
Jump to: navigation, search
SNX17
Protein SNX17 PDB 3FOG.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SNX17
External IDs MGI: 2387801 HomoloGene: 8838 GeneCards: SNX17
RNA expression pattern
PBB GE SNX17 200991 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001267059
NM_001267060
NM_001267061
NM_014748

NM_153680

RefSeq (protein)

NP_001253988
NP_001253989
NP_001253990
NP_055563

NP_710147.1
NP_710147

Location (UCSC) Chr 2: 27.37 – 27.38 Mb Chr 5: 31.19 – 31.2 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Sorting nexin-17 is a protein that in humans is encoded by the SNX17 gene.[3][4][5]

Function[edit]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin.[5]

Interactions[edit]

SNX17 has been shown to interact with Low density lipoprotein receptor-related protein 8[3]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b Stockinger W, Sailler B, Strasser V, Recheis B, Fasching D, Kahr L, Schneider WJ, Nimpf J (Aug 2002). "The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor". EMBO J. 21 (16): 4259–67. doi:10.1093/emboj/cdf435. PMC 126172Freely accessible. PMID 12169628. 
  4. ^ Knauth P, Schlüter T, Czubayko M, Kirsch C, Florian V, Schreckenberger S, Hahn H, Bohnensack R (Mar 2005). "Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking". J. Mol. Biol. 347 (4): 813–25. doi:10.1016/j.jmb.2005.02.004. PMID 15769472. 
  5. ^ a b "Entrez Gene: SNX17 sorting nexin 17". 

Further reading[edit]