SNX17

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SNX17
Protein SNX17 PDB 3FOG.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSNX17, sorting nexin 17
External IDsOMIM: 605963 MGI: 2387801 HomoloGene: 8838 GeneCards: SNX17
Gene location (Human)
Chromosome 2 (human)
Chr.Chromosome 2 (human)[1]
Chromosome 2 (human)
Genomic location for SNX17
Genomic location for SNX17
Band2p23.3Start27,370,496 bp[1]
End27,377,535 bp[1]
RNA expression pattern
PBB GE SNX17 200991 s at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001267059
NM_001267060
NM_001267061
NM_014748

NM_153680

RefSeq (protein)

NP_001253988
NP_001253989
NP_001253990
NP_055563

NP_710147

Location (UCSC)Chr 2: 27.37 – 27.38 MbChr 5: 31.19 – 31.2 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sorting nexin-17 is a protein that in humans is encoded by the SNX17 gene.[5][6][7]

Function[edit]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin.[7]

Interactions[edit]

SNX17 has been shown to interact with Low density lipoprotein receptor-related protein 8[5]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000115234 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029146 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Stockinger W, Sailler B, Strasser V, Recheis B, Fasching D, Kahr L, Schneider WJ, Nimpf J (Aug 2002). "The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor". EMBO J. 21 (16): 4259–67. doi:10.1093/emboj/cdf435. PMC 126172. PMID 12169628.
  6. ^ Knauth P, Schlüter T, Czubayko M, Kirsch C, Florian V, Schreckenberger S, Hahn H, Bohnensack R (Mar 2005). "Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking". J. Mol. Biol. 347 (4): 813–25. doi:10.1016/j.jmb.2005.02.004. PMID 15769472.
  7. ^ a b "Entrez Gene: SNX17 sorting nexin 17".

Further reading[edit]