STK3

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STK3
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases STK3, KRS1, MST2, serine/threonine kinase 3
External IDs MGI: 1928487 HomoloGene: 48420 GeneCards: STK3
Gene location (Human)
Chromosome 8 (human)
Chr. Chromosome 8 (human)[1]
Chromosome 8 (human)
Genomic location for STK3
Genomic location for STK3
Band 8q22.2 Start 98,401,403 bp[1]
End 98,942,827 bp[1]
RNA expression pattern
PBB GE STK3 204068 at fs.png

PBB GE STK3 211078 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001256312
NM_001256313
NM_006281

NM_019635
NM_001357821

RefSeq (protein)

NP_001243241
NP_001243242
NP_006272

NP_062609
NP_001344750

Location (UCSC) Chr 8: 98.4 – 98.94 Mb Chr 15: 34.88 – 35.18 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the STK3 gene.[5][6]

Protein kinase activation is a frequent response of cells to treatment with growth factors, chemicals, heat shock, or apoptosis-inducing agents. This protein kinase activation presumably allows cells to resist unfavorable environmental conditions. The yeast 'sterile 20' (Ste20) kinase acts upstream of the mitogen-activated protein kinase (MAPK) cascade that is activated under a variety of stress conditions. MST2 was first identified as a kinase that resembles budding yeast Ste20 (Creasy and Chernoff, 1996) and later as a kinase that is activated by the proapoptotic agents straurosporine and FAS ligand (MIM 134638) (Taylor et al., 1996; Lee et al., 2001).[supplied by OMIM][6]

References[edit]

Further reading[edit]