LATS2

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LATS2
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases LATS2, KPM, large tumor suppressor kinase 2
External IDs MGI: 1354386 HomoloGene: 56678 GeneCards: LATS2
RNA expression pattern
PBB GE LATS2 gnf1h02724 s at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_014572

NM_015771
NM_153382

RefSeq (protein)

NP_055387

NP_056586.2
NP_056586
NP_700431

Location (UCSC) Chr 13: 20.97 – 21.06 Mb Chr 14: 57.64 – 57.76 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine-protein kinase LATS2 is an enzyme that in humans is encoded by the LATS2 gene.[3][4]

This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ Yabuta N, Fujii T, Copeland NG, Gilbert DJ, Jenkins NA, Nishiguchi H, Endo Y, Toji S, Tanaka H, Nishimune Y, Nojima H (Apr 2000). "Structure, expression, and chromosome mapping of LATS2, a mammalian homologue of the Drosophila tumor suppressor gene lats/warts". Genomics. 63 (2): 263–70. doi:10.1006/geno.1999.6065. PMID 10673337. 
  4. ^ a b "Entrez Gene: LATS2 LATS, large tumor suppressor, homolog 2 (Drosophila)". 

Further reading[edit]