Talk:Organophosphate poisoning

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The opening paragraph tells of organophosphates causing the "suicide impulse" in farmers. The article never elaborates on this further. Indeed, it seems to convey that farmers have used these chemicals as a way of committing suicide, not that they put in some impulse into the minds of these men to kill themselves, (seemingly implied by the opening). Apologies if I'm way off the track, but I think it might need a bit of clarification here.-- (talk) 16:12, 18 April 2011 (UTC)

I altered the sentence to remove this issue and inserted references that people in agrarian areas do commit suicide using OPs. I haven't found a reference for the assertion that it is "one of the most common causes of poisoning worldwide". Skingski (talk) 21:57, 7 October 2011 (UTC)

For my biology class at Boston College, I had to edit a wikipedia page. I chose to edit OP poisoning, so a significant amount of information has been added to this page. I apologize if I have misinterpreted some of the studies in my writing on OP poisoning. Widrickm (talk) 04:17, 2 November 2011 (UTC)Widrickm

Classmates' Comments[edit]

The first line is concise and gets to the point quickly, which is a good thing. I think it would benefit the article if there was an explanation of why ACh accumulation is bad so the reader understands why organophosphates are harmful. Also, you jump right into talking about AChE inhibition. Someone might not understand enzyme mechanisms and why AChE inhibition is harmful which could make the initial science talk overwhelming so I would put everything more in layman’s terms for ease of understanding. Under the “examples” section, maybe you could mention routes of exposure. I understand that these examples contain organophosphates but telling the reader how it gets to them is powerful. For example, if you say “organophosphates from insectides run off into our waters from farmlands and are recycled into the water treatment plants.” Obviously what you say will be more sophisticated and accurate but a description of how it gets into people will make the article more relevant for readers because they realize their vulnerability. PON1 influence: if possible, include information about adult PON1 concentration and the toxic concentration of organophosphates so readers can have numbers to make sense of the information and understand why the topic is relevant. Ginger Jake: I know you already mentioned how ACh intoxication occurs but I think it would be helpful to mention again how it happens and why organophosphates can be debilitating. Even if the description were brief, “ACh accumulation happens after AChE is inhibited, etc.” just as a reminder to the reader about how the mechanism works. Governmental review: what are the effects of chronic organophosphate exposure in adults? Are there any mild symptoms that may cause the government to reconsider its allowance of organophosphates? Nicole — Preceding unsigned comment added by Rockaxis3 (talkcontribs) 20:01, 14 November 2011 (UTC)

Great job on the article! I think the intro is nice and easy to understand no matter what background a Wiki user has. My main suggestion would be an alteration in the organization of part of the article. You have all the examples listed right at the beginning in bullet form. I think it would be a good idea to not only list examples, but to also cite some studies showing the effects of those specific chemicals. In the Health Effects section, adding sections would help with organization. Subsections can be “Reproductive effects,” “Effects on fetuses and infants,” and “Neurotoxic effects." There is a very long paragraph that can be divided into a few smaller ones under "Neurotoxic effects." You can make a new paragraph for each of the neurotoxic effects possibly beginning with each of the following sentences:

  • “Cholinergic syndrome occurs in acute poisonings…”
  • “The intermediate syndrome (IMS) appears in the interveal between…”
  • “In a small percentage of cases, roughly two weeks after exposure…”
  • “COPIND occurs without cholinergic symptoms…”

You might want to create more Wiki links to or write brief definitions for certain words that the general public are not familiar with (cholinergic synapses, muscarinic, cholinesterases, nicotinic receptors, etc). In several paragraphs, just by looking at them, there are no linked words, so creating some will be helpful for users. Another minor edit that can be made is in the governmental review section where references are linked right after the sentence instead of there being a citation that brings you to the Reference section of the article.

Lastly, according to the assignment requirements, I think we need a section that talks about future research. For that section I’m sure you can discuss alternatives to organophosphate insecticides. Also you wrote under health effects that “More research is being done on animals and human fetuses to determine the effects of OP’s during critical periods of development” and then you discuss aviation lubricating oils. You can probably move that line and the paragraph on aviation oils to the future research section and expand by saying what else scientists are attempting to discover.

Overall, it's a well written article that explains everything well! I think the style or writing is very appropriate for a Wikipedia page as it not only is easy to understand for the public, but also goes into details that people studying science, like us, will find informative! Kbell90 (talk) 23:01, 14 November 2011 (UTC)Kbell90

The image for the article, showing phosphoric acid and details of its covalent bonds, is not at all relevant to the article. Phosphoric acid is not an organophosphate. This should be replaced with an image of the general structure of organophosphates. (talk) 18:32, 26 March 2013 (UTC)

Hi there. So far, the article is quite informative and concise. However, I think a bit more information could be added regarding the effects it may have on children --- Perhaps as a result of their activities and or diets could be related to a lesser or high risk of adverse effects of OPs? This link could be helpful: Effects of Organophosphates on Children` I also think it would be interesting to see if other countries besides the US have any legislation related to OP levels of exposure and use. Mbeez (talk) 00:45, 2 February 2015 (UTC)

Hi! The article has a great base structure to it, but I was most focused on the Research section. I understand that research is ever-changing and there might not be too much information available, but it would be amazing if this section could be expanded a bit more. You mention the aviation lubricants and I was wondering if it was possible to expand this a bit more, looking to whether the Aerotoxic Syndrome has been definitively linked to contaminated bleed air, as mentioned. Also, is there a source for this theory? Egilmore15 (talk) 19:55, 2 February 2015 (UTC)Egilmore15

Hello! I really enjoyed this article and thought it contained a lot of great overarching information on a topic that is being more and more heavily researched now! Just a few wording issues: the first paragraph (which I believe should be very strong considering it opens the article) is great. The only thing I think could be a bit better is the last sentence which states there are "about 1 million OP poisonings per year with several thousand resulting in fatalities annually." I think this could be reworded to" approximately 1 million OP poisonings occur each year with several thousand poisonings resulting in fatality. In addition, under causes there is a sentence which states: "Specifically in the blood, metabolites of cholinesterases, such as butyrylcholinesterase (BuChE) activity in plasma, neuropathy target esterase (NTE) in lymphocytes, and of acetylcholinesterase (AChE) activity in red blood cells.[19]” This is not a complete sentence. Two other informational issues is have are under the causes section and the historical examples section of the site. Under causes, the first sentence talks about how OP's disintegrate quickly in air and light, but further talks about how residues stay on fruits. This is a bit confusing and I wish there were more explanation about how they disintegrate in air and light, why this happens, and how this is then safe. Lastly I wish more symptomology was included under the two historical examples listed. (talk) 00:27, 3 February 2015 (UTC)Harleengs26

Organophosphate Pesticides Reports[edit]

Not sure why this was in the article? Doc James (talk · contribs · email) (if I write on your page reply on mine) 05:43, 10 April 2013 (UTC)

Expansion on suicide topic[edit]

You mentioned that many farmers have used organophosphates to commit intentional suicide, but did not say why. I've read in multiple articles and documentaries that they do it because of the regulations of large food corporations such as Monsanto. With building pest resistance to pesticides, they have to keep using more and more and the small landowners cannot keep up with larger landowners in terms of profit.

Here are a couple links to articles that mention these types of unfortunate situations:

Maybe you could pull information from sources 3, 4, and 5 of the pesticide poisoning wikipedia page as well? Or link certain keywords to that page.— Preceding unsigned comment added by Jak0313 (talkcontribs) 17:36, 31 January 2015‎ (UTC)

see Farmers' suicides in India - has more to do with the "liberalization" of the Indian economy, leaving farmers without good advice and without reasonable access to banks. Jytdog (talk) 21:00, 31 January 2015 (UTC)

Some Suggestions[edit]

I want to first start by saying that I think this is a very informative article! It helps people to understand the dangers of OP poisoning and how it is present in their daily lives!.

I have a few suggestions:

- In your section titled "Neurotoxic Effects", in the fourth paragraph, third sentence, you have written "Symptoms continue to worse..." when I think you meant to say "Symptoms continue to worsen"

- I think you could maybe expand upon your section on OP poisoning on developing animals. You could include information about how all of this could affect pregnant women and the developing fetus. I saw that you had this written above in the reproductive section, so if there is nothing additional to write in the "Developing Animal" section, maybe you could merge it with the "Reproductive Effects" section.

- I think you diagnosis section could be expanded upon. You mention that current testing only tests for two of the most common OPs. I think you could further expand on the implications of this and how diagnosis needs to change and how it can be bettered in the future.

Sej942 (talk) 02:00, 2 February 2015 (UTC)

More Suggestions[edit]

I also think this is a very informative article. The only suggestion I have is that you can now expand on the effects of OP exposure on infants and children.

User:bellre 2 February 2015 — Preceding undated comment added 16:25, 2 February 2015 (UTC)


Are the commentors here related to one another? is this a class activity or something? thanks Jytdog (talk) 20:31, 2 February 2015 (UTC)

Yes, this article appears to be targeted for improvement as a homework project for an undergraduate class at some college. The critical component will be the degree to which the instructor is knowledgeable of the topic and Wikipedia style.--Smokefoot (talk) 01:21, 3 February 2015 (UTC)

Separation of acute versus chronic poisoning ... fails NPOV?[edit]


It is very strange that this article seems to include almost nothing about the issue of chronic organophosphate exposure from the standpoint of public health (such as cases one has heard of in the past of sheep farmers exposed to sheep dip in their jobs over the years). It is like an article about car exhaust pollution that focused on people intentionally killing themselves with car exhaust, and nearly ignoring -- perhaps obscuring -- issues of much wider concern about global pollution, regulations, treaties, methods of limiting the problem.

Am I just paranoid, or is this reminding me of articles about tobacco one has seen which don't mention that it may be linked to lung cancer or heart disease, and focus on how nicotine may be a cure for alzheimer's disease etc. Not saying this for a fact but please some editor who knows something about this subject have a look, OK? Thx Createangelos (talk) 00:58, 30 January 2017 (UTC)

Refs for "chronic poisoning"? Doc James (talk · contribs · email) 01:31, 30 January 2017 (UTC)

Moving this here[edit]

Have moved here. I am having trouble figuring out what these refs are?

Chronic exposure—multiple exposures over time, from a few weeks to many years[1]—may manifest itself in very different ways from acute exposure. The toxicity (“ability of a substance to produce adverse effects”[2]), is more complex and subtle.[3] Acute--one immediate exposure[4]--poisoning

Are you referring to this ref?[1]? And if so were does it discuss the chronic toxicity of organophosphates? Doc James (talk · contribs · email) 11:18, 25 March 2017 (UTC)

Approximately 99% of those deaths occur in the developing world. [5]

This ref does not refer to OGs but to pesticide generally? Doc James (talk · contribs · email) 11:20, 25 March 2017 (UTC)

This article is not about pesticide poisoning generally. Doc James (talk · contribs · email) 11:25, 25 March 2017 (UTC)


  1. ^ Nesheim, NO.; Fishel, FM.; Mossler, M. Toxicity of Pesticides. Agronomy Department UF/IFAS Extension; 2014; PI-13.
  2. ^ Nesheim, NO.; Fishel, FM.; Mossler, M. Toxicity of Pesticides. Agronomy Department UF/IFAS Extension; 2014; PI-13.
  3. ^ Nesheim, NO.; Fishel, FM.; Mossler, M. Toxicity of Pesticides. Agronomy Department UF/IFAS Extension; 2014; PI-13.
  4. ^ Nesheim, NO.; Fishel, FM.; Mossler, M. Toxicity of Pesticides. Agronomy Department UF/IFAS Extension; 2014; PI-13.
  5. ^ Human Rights Council. Report of the Special Rapporteur on the right to food. 2017; General Assembly, 34th session, Agenda item 3.


"While it can be described as an organophosphorus compound, glyphosate is not an organophosphate ester but a phosphanoglycine, and it does not inhibit cholinesterase activity." source May be worth removing it from article. Ratel (talk) 13:08, 25 April 2017 (UTC)

I removed it. I think we've removed similar content from organonphosphate articles in the past, but probably not at this one yet. Kingofaces43 (talk) 14:23, 25 April 2017 (UTC)
Thanks. That was my though initially. IARC sort of lists it as one[2]
But from a toxicology point of view I think they are mistaken. Doc James (talk · contribs · email) 18:40, 25 April 2017 (UTC)
Interesting .... but how so? What evidence is there that glyphosate acts like an organophosphate from a toxicological POV? Ratel (talk) 19:31, 25 April 2017 (UTC)
It does NOT act like an organophosphate from a toxicological perspective.
This source says it is about five organophosphates and lists glyphosate as one.[3] Doc James (talk · contribs · email) 19:52, 25 April 2017 (UTC)
Yeah, glyphosate definitely isn't an acetylcholinesterase inhibitor, to which organophosphate in this article title refers to. It also doesn't have a designated chemical family name either.[4] Kingofaces43 (talk) 20:41, 25 April 2017 (UTC)