Titi was born in Jakarta. She began singing on public television as a teenager, hoping a record company would notice. At age 17 in 1983, she represented Indonesia in the Miss World competition, but was not a finalist. Also a dancer, she performed with Guruh Soekarnoputra's Swara Mahardhikka troupe. She sang backup vocals for Chrisye and appeared in a few movies early in her career. She released her first solo album in 1984, Imajinasi. Her singing career flourished in the 1990s, with the hit singles "Bintang-Bintang" ("Stars"), "Ekspresi" ("Expression") and "Salahkah Aku" ("Am I Wrong?"). Currently, she is one of the three Indonesian divas that formed a group together with Krisdayanti and Ruth Sahanaya called 3 Diva.
She was first married to actorBucek Depp in 1995, with whom she has three children, twin daughters Salma and Salwa Mucthar and a son Daffa Mucthar,. They divorced in 1997. Then she got married to American teacher Andy Dougharty in 1999, with whom she has one child Stephanie Dougharty. She divorced from Dougharty in 2006. She also had a previous six-year relationship with one of her musical collaborators, Indra Lesmana.