User:Bartimaeus/Sandbox

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My Sandbox[edit]

Put together a page on Mitochondrial inheritance. Bartimaeus 23:43, 10 November 2005 (UTC)

Ames test needs a lot of work. Bartimaeus 07:18, 16 November 2005 (UTC)

articles in need of my attention[edit]

COX, Peroxynitrite, Heroin, Nitrates, Nitrate tolerance, Furosemide, Glucuronidation, Probenecid.

Coronary heart disease add pharmacotherapy.

Pharmacology[edit]

Pharmacology (in Greek: pharmacon (φάρμακον) is drug, and logos (λόγος) is science) is the study of how chemical substances interact with living systems. If these substances have medicinal properties, they are referred to as pharmaceuticals. The field encompasses drug composition, drug properties, interactions, toxicology, and desirable effects that can be used in therapy of diseases.

Development of medication is a vital concern to medicine, but also has strong economical and political implications. To protect the consumer and prevent abuse, many governments regulate the manufacture, sale, and administration of medication. In the United States, the main regulatory body is the Food and Drug Administration through its publication of the USP.

Pharmacology as a science is practiced by pharmacologists. Subdisciplines are clinical pharmacology (the medical field of medication effects on humans), neuro- and psychopharmacology (effects of medication on behavior and nervous system functioning), and theoretical pharmacology.

Scientific background[edit]

The study of medicinal chemicals requires intimate knowledge of the biological system affected. With the knowledge of cell biology and biochemistry increasing, the field of pharmacology has also changed substantially. It has become possible, through molecular analysis of receptors, to design chemicals that act on specific cellular signalling or metabolic pathways by affecting sites directly on cell-surface receptors (which modulate and mediate cellular signalling pathways controlling cellular function).

A chemical has, from the pharmacological point-of-view, various properties. Pharmacokinetics describes its behaviour in the body - particularly in the blood (e.g. its half-life and volume of distribution), and pharmacodynamics relates its behaviour in the blood to its effects (desired effects or toxic side-effects).

When describing the pharmacokinetic properties of a chemical, pharmacologists are often interested in ADME:

  • Absorption - How is the medication absorbed (through the skin, the intestine, the oral mucosa)?
  • Distribution - How does it spread through the organism?
  • Metabolism - Is the medication converted chemically inside the body, and into which substances. Are these active? Could they be toxic?
  • Excretion - How is the medication eliminated (through the bile, urine, breath, skin)?

Medication is said to have a narrow or wide therapeutic index or therapeutic window. This describes the ratio of desired effect to toxic effect. A compound with a narrow therapeutic index (close to 1) exerts its desired effect at a dose close to its toxic dose. A compound with a wide therapeutic index (greater than 5) exerts its desired effect at a dose substantially below its toxic dose. Those with a narrow window are more difficult to dose and administer, and may require therapeutic drug monitoring (examples are warfarin, some antiepileptics, aminoglycoside antibiotics). Most anti-cancer drugs have a narrow therapeutic margin: toxic side-effects are almost always encountered at doses used to kill tumours.

Classification[edit]

Medication can be usually classified in various ways, e.g. by its chemical properties, mode of administration, or biological system affected. An elaborate and widely used classification system is the Anatomical Therapeutic Chemical Classification System.

External links[edit]

See also[edit]

Types of Medication[edit]

For the gastrointestinal tract or digestive system[edit]

For the cardiovascular system[edit]

For the central nervous system[edit]

hypnotic, anaesthetics, antipsychotic, antidepressant (including tricyclic antidepressants, monoamine oxidase inhibitor, lithium salt, selective serotonin reuptake inhibitor), anti-emetic, anticonvulsant and antiepileptic, anxiolytic, barbiturate, movement disorder drug, stimulant (including amphetamines), benzodiazepine, cyclopyrrolone, dopamine antagonist, antihistamine, cholinergic, anticholinergic, emetic, cannabinoids, 5-HT antagonist

For pain & consciousness (Analgesic drugs)[edit]

The main classes of painkillers are NSAIDs, opioids and various orphans such as paracetamol, tricyclic antidepressants and anticonvulsants.

For musculo-skeletal disorders[edit]

NSAIDs (including COX-2 selective inhibitors), muscle relaxant, neuromuscular drug
anticholinesterase

For the eye[edit]

For the ear, nose and oropharynx[edit]

sympathomimetic, antihistamine, anticholinergic, NSAIDs, steroid, antiseptic, local anesthetic, antifungal, cerumenolytic

For the respiratory system[edit]

bronchodilator, NSAIDs, anti-allergic, antitussive, mucolytic, decongestant
corticosteroid, beta-receptor antagonist, anticholinergic, steroid

For endocrine problems[edit]

androgen, antiandrogen, gonadotropin, corticosteroid, growth hormone, insulin, antidiabetic (sulfonylurea, biguanide/metformin, thiazolidinedione, insulin), thyroid hormones, antithyroid drugs, calcitonin, diphosponate, vasopressin analogues

For the reproductive system or urinary system[edit]

antifungal, alkalising agent, quinolones, antibiotic, cholinergic, anticholinergic, anticholinesterase, antispasmodic, 5-alpha reductase inhibitor, selective alpha-1 blocker, sildenafil

For contraception[edit]

contraceptive, oral contraceptives, spermicide, depot contraceptives

For obstetrics and gynaecology[edit]

NSAIDs, anticholinergic, haemostatic drug, antifibrinolytic, Hormone Replacement Therapy, bone regulator, beta-receptor agonist, follicle stimulating hormone, luteinising hormone, LHRH
gamolenic acid, gonadotropin release inhibitor, progestogen, dopamine agonist, oestrogen, prostaglandin, gonadorelin, clomiphene, tamoxifen, Diethylstilbestrol

For the skin[edit]

emollient, anti-pruritic, antifungal, disinfectant, scabicide, pediculicide, tar products, vitamin A derivatives, vitamin D analogue, keratolytic, abrasive, systemic antibiotic, topical antibiotic, hormones, desloughing agent, exudate absorbent, fibrinolytic, proteolytic, sunscreen, antiperspirant, corticosteroid

For infections and infestations[edit]

antibiotic, antifungal, antileprotic, antituberculous drug, antimalarial, anthelmintic, amoebicide, antiviral, antiprotozoal, antiserum

For immunology[edit]

vaccine, immunoglobulin, immunosuppressant, interferon, monoclonal antibody

For allergic disorders[edit]

anti-allergic, antihistamine, NSAIDs

For nutrition[edit]

tonic, iron preparation, electrolyte, parenteral nutritional supplement, vitamins, anti-obesity drug, anabolic drug, haematopoietic drug, food product drug

For neoplastic disorders[edit]

cytotoxic drug, sex hormones, aromatase inhibitor, somatostatin inhibitor, recombinant interleukins, G-CSF, erythropoietin

For diagnostics[edit]

contrast media

For euthanasia[edit]

A euthanaticum is used for euthanasia and physician-assisted suicide, see also barbiturates.

Other[edit]

Zoopharmacognosy: Animal usage of drugs and non-foods.