Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 21:23, 8 November 2007 (UTC)
[edit]Proteins without matches (18)
[edit]Proteins with a High Potential Match (7)
[edit]Manual Inspection (Page not found) (19)
[edit]
Protein Status Grid - Date: 21:23, 8 November 2007 (UTC)
[edit]Vebose Log - Date: 21:23, 8 November 2007 (UTC)
[edit]- INFO: Beginning work on ACTR2... {November 8, 2007 1:11:12 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein ACTR2 image.jpg {November 8, 2007 1:11:28 PM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 1:11:38 PM PST}
- CREATED: Created new protein page: ACTR2 {November 8, 2007 1:11:45 PM PST}
- INFO: Beginning work on C1QBP... {November 8, 2007 12:48:24 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein C1QBP image.jpg {November 8, 2007 12:49:14 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 12:49:35 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_C1QBP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1p32.
| PDB = {{PDB2|1p32}}
| Name = Complement component 1, q subcomponent binding protein
| HGNCid = 1243
| Symbol = C1QBP
| AltSymbols =; GC1QBP; HABP1; SF2p32; gC1Q-R; gC1qR; p32
| OMIM = 601269
| ECnumber =
| Homologene = 31023
| MGIid = 1194505
| GeneAtlas_image1 = PBB_GE_C1QBP_214214_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_C1QBP_208910_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005759 |text = mitochondrial matrix}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0006955 |text = immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 708
| Hs_Ensembl = ENSG00000108561
| Hs_RefseqProtein = NP_001203
| Hs_RefseqmRNA = NM_001212
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 5276676
| Hs_GenLoc_end = 5283125
| Hs_Uniprot = Q07021
| Mm_EntrezGene = 12261
| Mm_Ensembl = ENSMUSG00000018446
| Mm_RefseqmRNA = NM_007573
| Mm_RefseqProtein = NP_031599
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 70794002
| Mm_GenLoc_end = 70799169
| Mm_Uniprot = Q8R5L1
}}
}}
'''Complement component 1, q subcomponent binding protein''', also known as '''C1QBP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The human complement subcomponent C1q associates with C1r and C1s in order to yield the first component of the serum complement system. The protein encoded by this gene is known to bind to the globular heads of C1q molecules and inhibit C1 activation. This protein has also been identified as the p32 subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic acid-binding protein.<ref>{{cite web | title = Entrez Gene: C1QBP complement component 1, q subcomponent binding protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=708| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CAPN3... {November 8, 2007 12:49:35 PM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 12:52:08 PM PST}
- CREATED: Created new protein page: CAPN3 {November 8, 2007 12:52:15 PM PST}
- INFO: Beginning work on CAST... {November 8, 2007 12:52:15 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 12:53:47 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Calpastatin
| HGNCid = 1515
| Symbol = CAST
| AltSymbols =; BS-17; MGC9402
| OMIM = 114090
| ECnumber =
| Homologene = 7658
| MGIid = 1098236
| GeneAtlas_image1 = PBB_GE_CAST_212586_at_tn.png
| GeneAtlas_image2 = PBB_GE_CAST_207467_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_CAST_208908_s_at_tn.png
| Function = {{GNF_GO|id=GO:0030161 |text = calpain inhibitor activity}}
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 831
| Hs_Ensembl = ENSG00000153113
| Hs_RefseqProtein = NP_001035905
| Hs_RefseqmRNA = NM_001042440
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 96023533
| Hs_GenLoc_end = 96136143
| Hs_Uniprot = P20810
| Mm_EntrezGene = 12380
| Mm_Ensembl = ENSMUSG00000021585
| Mm_RefseqmRNA = XM_990139
| Mm_RefseqProtein = XP_995233
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 75160288
| Mm_GenLoc_end = 75274762
| Mm_Uniprot = Q3TTN2
}}
}}
'''Calpastatin''', also known as '''CAST''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length natures of only some have been determined.<ref>{{cite web | title = Entrez Gene: CAST calpastatin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=831| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Murachi T |title=Intracellular regulatory system involving calpain and calpastatin. |journal=Biochem. Int. |volume=18 |issue= 2 |pages= 263-94 |year= 1989 |pmid= 2548504 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CCL17... {November 8, 2007 12:58:42 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CCL17 image.jpg {November 8, 2007 12:59:13 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 12:59:34 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_CCL17_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1nr2.
| PDB = {{PDB2|1nr2}}, {{PDB2|1nr4}}
| Name = Chemokine (C-C motif) ligand 17
| HGNCid = 10615
| Symbol = CCL17
| AltSymbols =; A-152E5.3; ABCD-2; MGC138271; MGC138273; SCYA17; TARC
| OMIM = 601520
| ECnumber =
| Homologene = 2246
| MGIid = 1329039
| GeneAtlas_image1 = PBB_GE_CCL17_207900_at_tn.png
| Function = {{GNF_GO|id=GO:0008009 |text = chemokine activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6361
| Hs_Ensembl = ENSG00000102970
| Hs_RefseqProtein = NP_002978
| Hs_RefseqmRNA = NM_002987
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 56005294
| Hs_GenLoc_end = 56007475
| Hs_Uniprot = Q92583
| Mm_EntrezGene = 20295
| Mm_Ensembl = ENSMUSG00000031780
| Mm_RefseqmRNA = NM_011332
| Mm_RefseqProtein = NP_035462
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 97699582
| Mm_GenLoc_end = 97701164
| Mm_Uniprot =
}}
}}
'''Chemokine (C-C motif) ligand 17''', also known as '''CCL17''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells.<ref>{{cite web | title = Entrez Gene: CCL17 chemokine (C-C motif) ligand 17| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6361| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Saeki H, Tamaki K |title=Thymus and activation regulated chemokine (TARC)/CCL17 and skin diseases. |journal=J. Dermatol. Sci. |volume=43 |issue= 2 |pages= 75-84 |year= 2006 |pmid= 16859899 |doi= 10.1016/j.jdermsci.2006.06.002 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DCC... {November 8, 2007 12:53:47 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 12:54:04 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Deleted in colorectal carcinoma
| HGNCid = 2701
| Symbol = DCC
| AltSymbols =; CRC18; CRCR1
| OMIM = 120470
| ECnumber =
| Homologene = 21081
| MGIid = 94869
| Function = {{GNF_GO|id=GO:0004888 |text = transmembrane receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0030424 |text = axon}}
| Process = {{GNF_GO|id=GO:0001764 |text = neuron migration}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0006917 |text = induction of apoptosis}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007409 |text = axonogenesis}} {{GNF_GO|id=GO:0045786 |text = negative regulation of progression through cell cycle}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1630
| Hs_Ensembl = ENSG00000187323
| Hs_RefseqProtein = NP_005206
| Hs_RefseqmRNA = NM_005215
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 18
| Hs_GenLoc_start = 48121156
| Hs_GenLoc_end = 49311021
| Hs_Uniprot = P43146
| Mm_EntrezGene = 13176
| Mm_Ensembl = ENSMUSG00000060534
| Mm_RefseqmRNA = NM_007831
| Mm_RefseqProtein = NP_031857
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 18
| Mm_GenLoc_start = 71384359
| Mm_GenLoc_end = 72475815
| Mm_Uniprot = Q3TZP5
}}
}}
'''Deleted in colorectal carcinoma''', also known as '''DCC''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Friess H, Berberat P, Schilling M, ''et al.'' |title=Pancreatic cancer: the potential clinical relevance of alterations in growth factors and their receptors. |journal=J. Mol. Med. |volume=74 |issue= 1 |pages= 35-42 |year= 1996 |pmid= 8834768 |doi= }}
*{{cite journal | author=Arakawa H |title=Netrin-1 and its receptors in tumorigenesis. |journal=Nat. Rev. Cancer |volume=4 |issue= 12 |pages= 978-87 |year= 2005 |pmid= 15573119 |doi= 10.1038/nrc1504 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DCX... {November 8, 2007 12:54:04 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein DCX image.jpg {November 8, 2007 12:54:57 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 12:55:15 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_DCX_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1mjd.
| PDB = {{PDB2|1mjd}}, {{PDB2|2bqq}}
| Name = Doublecortex; lissencephaly, X-linked (doublecortin)
| HGNCid = 2714
| Symbol = DCX
| AltSymbols =; DBCN; DC; LISX; SCLH; XLIS
| OMIM = 300121
| ECnumber =
| Homologene = 7683
| MGIid = 1277171
| GeneAtlas_image1 = PBB_GE_DCX_204850_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_DCX_204851_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008017 |text = microtubule binding}}
| Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005875 |text = microtubule associated complex}}
| Process = {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007417 |text = central nervous system development}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1641
| Hs_Ensembl = ENSG00000077279
| Hs_RefseqProtein = NP_000546
| Hs_RefseqmRNA = NM_000555
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 110423663
| Hs_GenLoc_end = 110542259
| Hs_Uniprot = O43602
| Mm_EntrezGene = 13193
| Mm_Ensembl = ENSMUSG00000031285
| Mm_RefseqmRNA = NM_010025
| Mm_RefseqProtein = NP_034155
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 139102214
| Mm_GenLoc_end = 139179679
| Mm_Uniprot = Q3V349
}}
}}
'''Doublecortex; lissencephaly, X-linked (doublecortin)''', also known as '''DCX''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The protein encoded by this gene is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. The encoded protein contains two doublecortin domains, which bind microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene are a cause of X-linked lissencephaly. Multiple transcript variants encoding at least three different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: DCX doublecortex; lissencephaly, X-linked (doublecortin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1641| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DES... {November 8, 2007 12:55:15 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 12:56:16 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Desmin
| HGNCid = 2770
| Symbol = DES
| AltSymbols =; CMD1I; CSM1; CSM2; FLJ12025; FLJ39719; FLJ41013; FLJ41793
| OMIM = 125660
| ECnumber =
| Homologene = 56469
| MGIid = 94885
| GeneAtlas_image1 = PBB_GE_DES_202222_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_DES_214027_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005626 |text = insoluble fraction}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005882 |text = intermediate filament}} {{GNF_GO|id=GO:0030018 |text = Z disc}} {{GNF_GO|id=GO:0042383 |text = sarcolemma}} {{GNF_GO|id=GO:0043292 |text = contractile fiber}} {{GNF_GO|id=GO:0045202 |text = synapse}}
| Process = {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0007010 |text = cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0008016 |text = regulation of heart contraction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1674
| Hs_Ensembl = ENSG00000175084
| Hs_RefseqProtein = NP_001918
| Hs_RefseqmRNA = NM_001927
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 2
| Hs_GenLoc_start = 219991343
| Hs_GenLoc_end = 219999705
| Hs_Uniprot = P17661
| Mm_EntrezGene = 13346
| Mm_Ensembl = ENSMUSG00000026208
| Mm_RefseqmRNA = NM_010043
| Mm_RefseqProtein = NP_034173
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 75243492
| Mm_GenLoc_end = 75250864
| Mm_Uniprot = Q3V1K9
}}
}}
'''Desmin''', also known as '''DES''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network connecting myofibrils to each other and to the plasma membrane. Mutations in this gene are associated with desmin-related myopathy, a familial cardiac and skeletal myopathy (CSM), and with distal myopathies.<ref>{{cite web | title = Entrez Gene: DES desmin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1674| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Snásel J, Pichová I |title=The cleavage of host cell proteins by HIV-1 protease. |journal=Folia Biol. (Praha) |volume=42 |issue= 5 |pages= 227-30 |year= 1997 |pmid= 8997639 |doi= }}
*{{cite journal | author=Garbuglia M, Verzini M, Sorci G, ''et al.'' |title=The calcium-modulated proteins, S100A1 and S100B, as potential regulators of the dynamics of type III intermediate filaments. |journal=Braz. J. Med. Biol. Res. |volume=32 |issue= 10 |pages= 1177-85 |year= 2000 |pmid= 10510252 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DHFR... {November 8, 2007 12:56:16 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein DHFR image.jpg {November 8, 2007 12:56:30 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 12:56:38 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_DHFR_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1boz.
| PDB = {{PDB2|1boz}}, {{PDB2|1dhf}}, {{PDB2|1dlr}}, {{PDB2|1dls}}, {{PDB2|1drf}}, {{PDB2|1hfp}}, {{PDB2|1hfq}}, {{PDB2|1hfr}}, {{PDB2|1kms}}, {{PDB2|1kmv}}, {{PDB2|1mvs}}, {{PDB2|1mvt}}, {{PDB2|1ohj}}, {{PDB2|1ohk}}, {{PDB2|1pd8}}, {{PDB2|1pd9}}, {{PDB2|1pdb}}, {{PDB2|1s3u}}, {{PDB2|1s3v}}, {{PDB2|1s3w}}, {{PDB2|1u71}}, {{PDB2|1u72}}, {{PDB2|1yho}}, {{PDB2|2c2s}}, {{PDB2|2c2t}}, {{PDB2|2dhf}}
| Name = Dihydrofolate reductase
| HGNCid = 2861
| Symbol = DHFR
| AltSymbols =;
| OMIM = 126060
| ECnumber =
| Homologene = 56470
| MGIid = 94890
| Function = {{GNF_GO|id=GO:0004146 |text = dihydrofolate reductase activity}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0050661 |text = NADP binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}}
| Process = {{GNF_GO|id=GO:0006545 |text = glycine biosynthetic process}} {{GNF_GO|id=GO:0006730 |text = one-carbon compound metabolic process}} {{GNF_GO|id=GO:0009165 |text = nucleotide biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 1719
| Hs_Ensembl =
| Hs_RefseqProtein = NP_000782
| Hs_RefseqmRNA = NM_000791
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 13361
| Mm_Ensembl = ENSMUSG00000021707
| Mm_RefseqmRNA = NM_010049
| Mm_RefseqProtein = NP_034179
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 93455536
| Mm_GenLoc_end = 93489806
| Mm_Uniprot = Q544T5
}}
}}
'''Dihydrofolate reductase''', also known as '''DHFR''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia.<ref>{{cite web | title = Entrez Gene: DHFR dihydrofolate reductase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1719| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Banerjee D, Mayer-Kuckuk P, Capiaux G, ''et al.'' |title=Novel aspects of resistance to drugs targeted to dihydrofolate reductase and thymidylate synthase. |journal=Biochim. Biophys. Acta |volume=1587 |issue= 2-3 |pages= 164-73 |year= 2002 |pmid= 12084458 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on DST... {November 8, 2007 12:45:26 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein DST image.jpg {November 8, 2007 12:47:32 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 12:48:24 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_DST_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2iak.
| PDB = {{PDB2|2iak}}
| Name = Dystonin
| HGNCid = 1090
| Symbol = DST
| AltSymbols =; BP240; BPA; BPAG1; CATX-15; D6S1101; DMH; FLJ46791; KIAA0465; KIAA1470; MACF2
| OMIM = 113810
| ECnumber =
| Homologene = 81841
| MGIid =
| GeneAtlas_image1 = PBB_GE_DST_212253_x_at_tn.png
| GeneAtlas_image2 = PBB_GE_DST_212254_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_DST_215016_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005178 |text = integrin binding}} {{GNF_GO|id=GO:0005200 |text = structural constituent of cytoskeleton}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008022 |text = protein C-terminus binding}} {{GNF_GO|id=GO:0051015 |text = actin filament binding}}
| Component = {{GNF_GO|id=GO:0005604 |text = basement membrane}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005911 |text = intercellular junction}} {{GNF_GO|id=GO:0016023 |text = cytoplasmic membrane-bound vesicle}} {{GNF_GO|id=GO:0030056 |text = hemidesmosome}}
| Process = {{GNF_GO|id=GO:0007010 |text = cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007229 |text = integrin-mediated signaling pathway}} {{GNF_GO|id=GO:0008090 |text = retrograde axon cargo transport}} {{GNF_GO|id=GO:0030036 |text = actin cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0045104 |text = intermediate filament cytoskeleton organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 667
| Hs_Ensembl = ENSG00000151914
| Hs_RefseqProtein = NP_001714
| Hs_RefseqmRNA = NM_001723
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 56430744
| Hs_GenLoc_end = 56927363
| Hs_Uniprot = O94833
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Dystonin''', also known as '''DST''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the plakin protein family of adhesion junction plaque proteins. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of some variants has not been defined. It has been known that some isoforms are expressed in neural and muscle tissue, anchoring neural intermediate filaments to the actin cytoskeleton, and some isoforms are expressed in epithelial tissue, anchoring keratin-containing intermediate filaments to hemidesmosomes. Consistent with the expression, mice defective for this gene show skin blistering and neurodegeneration.<ref>{{cite web | title = Entrez Gene: DST dystonin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=667| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on HIST2H2BE... {November 8, 2007 1:08:25 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein HIST2H2BE image.jpg {November 8, 2007 1:09:05 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:09:30 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_HIST2H2BE_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1aoi.
| PDB = {{PDB2|1aoi}}, {{PDB2|1eqz}}, {{PDB2|1f66}}, {{PDB2|1hio}}, {{PDB2|1hq3}}, {{PDB2|1kx3}}, {{PDB2|1kx4}}, {{PDB2|1kx5}}, {{PDB2|1m18}}, {{PDB2|1m19}}, {{PDB2|1m1a}}, {{PDB2|1p34}}, {{PDB2|1p3a}}, {{PDB2|1p3b}}, {{PDB2|1p3f}}, {{PDB2|1p3g}}, {{PDB2|1p3i}}, {{PDB2|1p3k}}, {{PDB2|1p3l}}, {{PDB2|1p3m}}, {{PDB2|1p3o}}, {{PDB2|1p3p}}, {{PDB2|1s32}}, {{PDB2|1tzy}}, {{PDB2|1u35}}, {{PDB2|1zbb}}, {{PDB2|1zla}}, {{PDB2|2aro}}, {{PDB2|2cv5}}, {{PDB2|2f8n}}, {{PDB2|2fj7}}, {{PDB2|2hio}}, {{PDB2|2nzd}}
| Name = Histone cluster 2, H2be
| HGNCid = 4760
| Symbol = HIST2H2BE
| AltSymbols =; H2B.1; GL105; H2B; H2B/q; H2BFQ; MGC129733; MGC129734
| OMIM = 601831
| ECnumber =
| Homologene = 88682
| MGIid = 2448387
| GeneAtlas_image1 = PBB_GE_HIST2H2BE_202708_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}}
| Component = {{GNF_GO|id=GO:0000786 |text = nucleosome}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}}
| Process = {{GNF_GO|id=GO:0006334 |text = nucleosome assembly}} {{GNF_GO|id=GO:0007001 |text = chromosome organization and biogenesis (sensu Eukaryota)}} {{GNF_GO|id=GO:0042742 |text = defense response to bacterium}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8349
| Hs_Ensembl = ENSG00000184678
| Hs_RefseqProtein = NP_003519
| Hs_RefseqmRNA = NM_003528
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 148122633
| Hs_GenLoc_end = 148124826
| Hs_Uniprot = Q16778
| Mm_EntrezGene = 319182
| Mm_Ensembl = ENSMUSG00000064168
| Mm_RefseqmRNA = NM_178197
| Mm_RefseqProtein = NP_835504
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 23550437
| Mm_GenLoc_end = 23550817
| Mm_Uniprot = Q64478
}}
}}
'''Histone cluster 2, H2be''', also known as '''HIST2H2BE''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2B family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.<ref>{{cite web | title = Entrez Gene: HIST2H2BE histone cluster 2, H2be| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8349| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on NCF1... {November 8, 2007 1:13:45 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein NCF1 image.jpg {November 8, 2007 1:14:01 PM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 1:14:17 PM PST}
- CREATED: Created new protein page: NCF1 {November 8, 2007 1:14:24 PM PST}
- INFO: Beginning work on PDCD6IP... {November 8, 2007 1:10:07 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PDCD6IP image.jpg {November 8, 2007 1:10:51 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:11:12 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PDCD6IP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2oev.
| PDB = {{PDB2|2oev}}, {{PDB2|2oew}}, {{PDB2|2oex}}, {{PDB2|2ojq}}
| Name = Programmed cell death 6 interacting protein
| HGNCid = 8766
| Symbol = PDCD6IP
| AltSymbols =; AIP1; Alix; DRIP4; HP95; MGC17003
| OMIM = 608074
| ECnumber =
| Homologene = 22614
| MGIid = 1333753
| GeneAtlas_image1 = PBB_GE_PDCD6IP_217746_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005829 |text = cytosol}}
| Process = {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10015
| Hs_Ensembl = ENSG00000170248
| Hs_RefseqProtein = NP_037506
| Hs_RefseqmRNA = NM_013374
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 33814561
| Hs_GenLoc_end = 33886198
| Hs_Uniprot = Q8WUM4
| Mm_EntrezGene = 18571
| Mm_Ensembl = ENSMUSG00000032504
| Mm_RefseqmRNA = NM_011052
| Mm_RefseqProtein = NP_035182
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 113501953
| Mm_GenLoc_end = 113556927
| Mm_Uniprot = Q3TED2
}}
}}
'''Programmed cell death 6 interacting protein''', also known as '''PDCD6IP''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a protein thought to participate in programmed cell death. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization which may be partly responsible for the protection against cell death.<ref>{{cite web | title = Entrez Gene: PDCD6IP programmed cell death 6 interacting protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10015| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PRPH2... {November 8, 2007 12:58:00 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 12:58:42 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Peripherin 2 (retinal degeneration, slow)
| HGNCid = 9942
| Symbol = PRPH2
| AltSymbols =; PRPH; AOFMD; AVMD; RDS; RP7; TSPAN22; rd2
| OMIM = 179605
| ECnumber =
| Homologene = 273
| MGIid = 102791
| GeneAtlas_image1 = PBB_GE_PRPH2_206625_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5961
| Hs_Ensembl = ENSG00000112619
| Hs_RefseqProtein = NP_000313
| Hs_RefseqmRNA = NM_000322
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 42772318
| Hs_GenLoc_end = 42798290
| Hs_Uniprot = P23942
| Mm_EntrezGene = 19133
| Mm_Ensembl = ENSMUSG00000023978
| Mm_RefseqmRNA = NM_008938
| Mm_RefseqProtein = NP_032964
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 46373676
| Mm_GenLoc_end = 46388117
| Mm_Uniprot = Q3UWK3
}}
}}
'''Peripherin 2 (retinal degeneration, slow)''', also known as '''PRPH2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein found in the outer segment of both rod and cone photoreceptor cells. It may function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. This protein is essential for disk morphogenesis. Defects in this gene are associated with both central and peripheral retinal degenerations. Some of the various phenotypically different disorders are autosomal dominant retinitis pigmentosa, progressive macular degeneration, macular dystrophy and retinitis pigmentosa digenic.<ref>{{cite web | title = Entrez Gene: PRPH2 peripherin 2 (retinal degeneration, slow)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5961| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Berditchevski F |title=Complexes of tetraspanins with integrins: more than meets the eye. |journal=J. Cell. Sci. |volume=114 |issue= Pt 23 |pages= 4143-51 |year= 2002 |pmid= 11739647 |doi= }}
*{{cite journal | author=Boesze-Battaglia K, Goldberg AF |title=Photoreceptor renewal: a role for peripherin/rds. |journal=Int. Rev. Cytol. |volume=217 |issue= |pages= 183-225 |year= 2002 |pmid= 12019563 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PSME3... {November 8, 2007 1:11:45 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:13:45 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
| HGNCid = 9570
| Symbol = PSME3
| AltSymbols =; Ki; PA28-gamma; PA28G; REG-GAMMA
| OMIM = 605129
| ECnumber =
| Homologene = 2111
| MGIid = 1096366
| GeneAtlas_image1 = PBB_GE_PSME3_200988_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PSME3_200987_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_PSME3_209852_x_at_tn.png
| Function = {{GNF_GO|id=GO:0008538 |text = proteasome activator activity}} {{GNF_GO|id=GO:0042802 |text = identical protein binding}}
| Component = {{GNF_GO|id=GO:0000502 |text = proteasome complex (sensu Eukaryota)}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0008537 |text = proteasome activator complex}}
| Process =
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 10197
| Hs_Ensembl = ENSG00000131467
| Hs_RefseqProtein = NP_005780
| Hs_RefseqmRNA = NM_005789
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 38238949
| Hs_GenLoc_end = 38249301
| Hs_Uniprot = P61289
| Mm_EntrezGene = 19192
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_011192
| Mm_RefseqProtein = NP_035322
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)''', also known as '''PSME3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the gamma subunit of the 11S regulator. Six gamma subunits combine to form a homohexameric ring. Two transcript variants encoding different isoforms have been identified.<ref>{{cite web | title = Entrez Gene: PSME3 proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10197| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Coux O, Tanaka K, Goldberg AL |title=Structure and functions of the 20S and 26S proteasomes. |journal=Annu. Rev. Biochem. |volume=65 |issue= |pages= 801-47 |year= 1996 |pmid= 8811196 |doi= 10.1146/annurev.bi.65.070196.004101 }}
*{{cite journal | author=Goff SP |title=Death by deamination: a novel host restriction system for HIV-1. |journal=Cell |volume=114 |issue= 3 |pages= 281-3 |year= 2003 |pmid= 12914693 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PTPN13... {November 8, 2007 12:57:02 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PTPN13 image.jpg {November 8, 2007 12:57:37 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 12:58:00 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PTPN13_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1d5g.
| PDB = {{PDB2|1d5g}}, {{PDB2|1gm1}}, {{PDB2|1ozi}}, {{PDB2|1q7x}}, {{PDB2|1vj6}}, {{PDB2|1wch}}, {{PDB2|3pdz}}
| Name = Protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
| HGNCid = 9646
| Symbol = PTPN13
| AltSymbols =; DKFZp686J1497; FAP-1; PNP1; PTP-BAS; PTP-BL; PTP1E; PTPL1; PTPLE
| OMIM = 600267
| ECnumber =
| Homologene = 7909
| MGIid = 103293
| GeneAtlas_image1 = PBB_GE_PTPN13_204201_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004726 |text = non-membrane spanning protein tyrosine phosphatase activity}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}}
| Process = {{GNF_GO|id=GO:0006470 |text = protein amino acid dephosphorylation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5783
| Hs_Ensembl = ENSG00000163629
| Hs_RefseqProtein = NP_006255
| Hs_RefseqmRNA = NM_006264
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 87734909
| Hs_GenLoc_end = 87955326
| Hs_Uniprot = Q12923
| Mm_EntrezGene = 19249
| Mm_Ensembl = ENSMUSG00000034573
| Mm_RefseqmRNA = NM_011204
| Mm_RefseqProtein = NP_035334
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 103665481
| Mm_GenLoc_end = 103838654
| Mm_Uniprot = Q6PG62
}}
}}
'''Protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)''', also known as '''PTPN13''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large protein that possesses a PTP domain at C-terminus, and multiple noncatalytic domains, which include a domain with similarity to band 4.1 superfamily of cytoskeletal-associated proteins, a region consisting of five PDZ domains, and a leucine zipper motif. This PTP was found to interact with, and dephosphorylate Fas receptor, as well as IkappaBalpha through the PDZ domains, which suggested its role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathway. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.<ref>{{cite web | title = Entrez Gene: PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5783| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PYY... {November 8, 2007 12:56:38 PM PST}
- UPLOAD: Added new Image to wiki:
{November 8, 2007 12:56:52 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 12:57:02 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PYY_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1qbf.
| PDB = {{PDB2|1qbf}}, {{PDB2|1ru5}}, {{PDB2|1ruu}}, {{PDB2|2dez}}, {{PDB2|2df0}}
| Name = Peptide YY
| HGNCid = 9748
| Symbol = PYY
| AltSymbols =; PYY1
| OMIM = 600781
| ECnumber =
| Homologene = 3066
| MGIid = 99924
| Function = {{GNF_GO|id=GO:0005179 |text = hormone activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007010 |text = cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007586 |text = digestion}} {{GNF_GO|id=GO:0007631 |text = feeding behavior}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5697
| Hs_Ensembl = ENSG00000131096
| Hs_RefseqProtein = NP_004151
| Hs_RefseqmRNA = NM_004160
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 17
| Hs_GenLoc_start = 39385637
| Hs_GenLoc_end = 39437363
| Hs_Uniprot = P10082
| Mm_EntrezGene = 217212
| Mm_Ensembl = ENSMUSG00000017311
| Mm_RefseqmRNA = NM_145435
| Mm_RefseqProtein = NP_663410
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 101922932
| Mm_GenLoc_end = 101923442
| Mm_Uniprot = Q3V334
}}
}}
'''Peptide YY''', also known as '''PYY''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Ekblad E, Sundler F |title=Distribution of pancreatic polypeptide and peptide YY. |journal=Peptides |volume=23 |issue= 2 |pages= 251-61 |year= 2002 |pmid= 11825640 |doi= }}
*{{cite journal | author=Sandström O, El-Salhy M |title=Ontogeny and the effect of aging on pancreatic polypeptide and peptide YY. |journal=Peptides |volume=23 |issue= 2 |pages= 263-7 |year= 2002 |pmid= 11825641 |doi= }}
*{{cite journal | author=Yang H |title=Central and peripheral regulation of gastric acid secretion by peptide YY. |journal=Peptides |volume=23 |issue= 2 |pages= 349-58 |year= 2002 |pmid= 11825649 |doi= }}
*{{cite journal | author=Naruse S, Kitagawa M, Ishiguro H, Hayakawa T |title=Feedback regulation of pancreatic secretion by peptide YY. |journal=Peptides |volume=23 |issue= 2 |pages= 359-65 |year= 2002 |pmid= 11825650 |doi= }}
*{{cite journal | author=Aponte GW |title=PYY-mediated fatty acid induced intestinal differentiation. |journal=Peptides |volume=23 |issue= 2 |pages= 367-76 |year= 2002 |pmid= 11825651 |doi= }}
*{{cite journal | author=Hagan MM |title=Peptide YY: a key mediator of orexigenic behavior. |journal=Peptides |volume=23 |issue= 2 |pages= 377-82 |year= 2002 |pmid= 11825652 |doi= }}
*{{cite journal | author=Mannon PJ |title=Peptide YY as a growth factor for intestinal epithelium. |journal=Peptides |volume=23 |issue= 2 |pages= 383-8 |year= 2002 |pmid= 11825653 |doi= }}
*{{cite journal | author=Tseng WW, Liu CD |title=Peptide YY and cancer: current findings and potential clinical applications. |journal=Peptides |volume=23 |issue= 2 |pages= 389-95 |year= 2002 |pmid= 11825654 |doi= }}
*{{cite journal | author=El-Salhy M, Suhr O, Danielsson A |title=Peptide YY in gastrointestinal disorders. |journal=Peptides |volume=23 |issue= 2 |pages= 397-402 |year= 2002 |pmid= 11825655 |doi= }}
*{{cite journal | author=Imamura M |title=Effects of surgical manipulation of the intestine on peptide YY and its physiology. |journal=Peptides |volume=23 |issue= 2 |pages= 403-7 |year= 2002 |pmid= 11825656 |doi= }}
*{{cite journal | author=Beglinger C, Degen L |title=Gastrointestinal satiety signals in humans--physiologic roles for GLP-1 and PYY? |journal=Physiol. Behav. |volume=89 |issue= 4 |pages= 460-4 |year= 2007 |pmid= 16828127 |doi= 10.1016/j.physbeh.2006.05.048 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RIPK1... {November 8, 2007 1:09:30 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:10:07 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Receptor (TNFRSF)-interacting serine-threonine kinase 1
| HGNCid = 10019
| Symbol = RIPK1
| AltSymbols =; RIP; FLJ39204
| OMIM = 603453
| ECnumber =
| Homologene = 2820
| MGIid = 108212
| GeneAtlas_image1 = PBB_GE_RIPK1_209941_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006915 |text = apoptosis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8737
| Hs_Ensembl = ENSG00000137275
| Hs_RefseqProtein = NP_003795
| Hs_RefseqmRNA = NM_003804
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 3009212
| Hs_GenLoc_end = 3060418
| Hs_Uniprot = Q13546
| Mm_EntrezGene = 19766
| Mm_Ensembl = ENSMUSG00000021408
| Mm_RefseqmRNA = NM_009068
| Mm_RefseqProtein = NP_033094
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 13
| Mm_GenLoc_start = 34010339
| Mm_GenLoc_end = 34042635
| Mm_Uniprot = Q60855
}}
}}
'''Receptor (TNFRSF)-interacting serine-threonine kinase 1''', also known as '''RIPK1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Festjens N, Vanden Berghe T, Cornelis S, Vandenabeele P |title=RIP1, a kinase on the crossroads of a cell's decision to live or die. |journal=Cell Death Differ. |volume=14 |issue= 3 |pages= 400-10 |year= 2007 |pmid= 17301840 |doi= 10.1038/sj.cdd.4402085 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SLC22A5... {November 8, 2007 12:59:34 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:00:13 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 22 (organic cation transporter), member 5
| HGNCid = 10969
| Symbol = SLC22A5
| AltSymbols =; CDSP; FLJ46769; OCTN2
| OMIM = 603377
| ECnumber =
| Homologene = 68295
| MGIid = 1329012
| GeneAtlas_image1 = PBB_GE_SLC22A5_205074_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0015075 |text = ion transmembrane transporter activity}} {{GNF_GO|id=GO:0015226 |text = carnitine transporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} {{GNF_GO|id=GO:0015879 |text = carnitine transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6584
| Hs_Ensembl = ENSG00000197375
| Hs_RefseqProtein = NP_003051
| Hs_RefseqmRNA = NM_003060
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 131733343
| Hs_GenLoc_end = 131759205
| Hs_Uniprot = O76082
| Mm_EntrezGene = 20520
| Mm_Ensembl = ENSMUSG00000018900
| Mm_RefseqmRNA = NM_011396
| Mm_RefseqProtein = NP_035526
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 11
| Mm_GenLoc_start = 53707951
| Mm_GenLoc_end = 53735083
| Mm_Uniprot = Q3USA0
}}
}}
'''Solute carrier family 22 (organic cation transporter), member 5''', also known as '''SLC22A5''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is a plasma integral membrane protein which functions both as an organic cation transporter and as a sodium-dependent high affinity carnitine transporter. The encoded protein is involved in the active cellular uptake of carnitine. Mutations in this gene are the cause of systemic primary carnitine deficiency (CDSP), an autosomal recessive disorder manifested early in life by hypoketotic hypoglycemia and acute metabolic decompensation, and later in life by skeletal myopathy or cardiomyopathy.<ref>{{cite web | title = Entrez Gene: SLC22A5 solute carrier family 22 (organic cation transporter), member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6584| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Silverberg MS |title=OCTNs: will the real IBD5 gene please stand up? |journal=World J. Gastroenterol. |volume=12 |issue= 23 |pages= 3678-81 |year= 2006 |pmid= 16773684 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SMARCA2... {November 8, 2007 1:00:13 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SMARCA2 image.jpg {November 8, 2007 1:02:09 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:02:39 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_SMARCA2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2dat.
| PDB = {{PDB2|2dat}}
| Name = SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
| HGNCid = 11098
| Symbol = SMARCA2
| AltSymbols =; SWI2; BAF190; BRM; FLJ36757; MGC74511; SNF2; SNF2L2; SNF2LA; Sth1p; hBRM; hSNF2a
| OMIM = 600014
| ECnumber =
| Homologene = 2308
| MGIid = 99603
| GeneAtlas_image1 = PBB_GE_SMARCA2_206542_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SMARCA2_206544_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_SMARCA2_217707_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0004386 |text = helicase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6595
| Hs_Ensembl = ENSG00000080503
| Hs_RefseqProtein = NP_003061
| Hs_RefseqmRNA = NM_003070
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 9
| Hs_GenLoc_start = 2005342
| Hs_GenLoc_end = 2183624
| Hs_Uniprot = P51531
| Mm_EntrezGene = 67155
| Mm_Ensembl = ENSMUSG00000024921
| Mm_RefseqmRNA = NM_011416
| Mm_RefseqProtein = NP_035546
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 19
| Mm_GenLoc_start = 26672257
| Mm_GenLoc_end = 26845418
| Mm_Uniprot =
}}
}}
'''SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2''', also known as '''SMARCA2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. Two transcript variants encoding different isoforms have been found for this gene, which contains a trinucleotide repeat (CAG) length polymorphism.<ref>{{cite web | title = Entrez Gene: SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6595| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SMPD1... {November 8, 2007 1:02:39 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:03:39 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase)
| HGNCid = 11120
| Symbol = SMPD1
| AltSymbols =; ASM; NPD
| OMIM = 607608
| ECnumber =
| Homologene = 457
| MGIid = 98325
| GeneAtlas_image1 = PBB_GE_SMPD1_209420_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SMPD1_216230_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0004767 |text = sphingomyelin phosphodiesterase activity}} {{GNF_GO|id=GO:0008907 |text = integrase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}} {{GNF_GO|id=GO:0016798 |text = hydrolase activity, acting on glycosyl bonds}}
| Component = {{GNF_GO|id=GO:0005764 |text = lysosome}}
| Process = {{GNF_GO|id=GO:0006685 |text = sphingomyelin catabolic process}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007399 |text = nervous system development}} {{GNF_GO|id=GO:0008152 |text = metabolic process}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6609
| Hs_Ensembl = ENSG00000166311
| Hs_RefseqProtein = NP_000534
| Hs_RefseqmRNA = NM_000543
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 6368231
| Hs_GenLoc_end = 6372801
| Hs_Uniprot = P17405
| Mm_EntrezGene = 20597
| Mm_Ensembl = ENSMUSG00000037049
| Mm_RefseqmRNA = NM_011421
| Mm_RefseqProtein = NP_035551
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 105428213
| Mm_GenLoc_end = 105432204
| Mm_Uniprot = Q3UEE0
}}
}}
'''Sphingomyelin phosphodiesterase 1, acid lysosomal (acid sphingomyelinase)''', also known as '''SMPD1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Stoffel W |title=Functional analysis of acid and neutral sphingomyelinases in vitro and in vivo. |journal=Chem. Phys. Lipids |volume=102 |issue= 1-2 |pages= 107-21 |year= 2000 |pmid= 11001565 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SNRP70... {November 8, 2007 1:03:39 PM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 1:04:19 PM PST}
- CREATED: Created new protein page: SNRP70 {November 8, 2007 1:04:29 PM PST}
- INFO: Beginning work on TCF2... {November 8, 2007 1:04:29 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TCF2 image.jpg {November 8, 2007 1:05:06 PM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 1:05:28 PM PST}
- CREATED: Created new protein page: TCF2 {November 8, 2007 1:05:35 PM PST}
- INFO: Beginning work on TCP1... {November 8, 2007 1:05:35 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 8, 2007 1:06:52 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = T-complex 1
| HGNCid = 11655
| Symbol = TCP1
| AltSymbols =; CCT-alpha; CCT1; CCTa; D6S230E; TCP-1-alpha
| OMIM = 186980
| ECnumber =
| Homologene = 5656
| MGIid = 98535
| GeneAtlas_image1 = PBB_GE_TCP1_222011_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_TCP1_208778_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_TCP1_222010_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component = {{GNF_GO|id=GO:0000242 |text = pericentriolar material}} {{GNF_GO|id=GO:0005720 |text = nuclear heterochromatin}} {{GNF_GO|id=GO:0005815 |text = microtubule organizing center}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0005832 |text = chaperonin-containing T-complex}}
| Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0007021 |text = tubulin folding}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6950
| Hs_Ensembl = ENSG00000120438
| Hs_RefseqProtein = NP_001008897
| Hs_RefseqmRNA = NM_001008897
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 6
| Hs_GenLoc_start = 160119520
| Hs_GenLoc_end = 160130731
| Hs_Uniprot = P17987
| Mm_EntrezGene = 21454
| Mm_Ensembl = ENSMUSG00000068039
| Mm_RefseqmRNA = NM_013686
| Mm_RefseqProtein = NP_038714
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 17
| Mm_GenLoc_start = 12759413
| Mm_GenLoc_end = 12767488
| Mm_Uniprot = Q3TJ96
}}
}}
'''T-complex 1''', also known as '''TCP1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
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| summary_text = This gene encodes a molecular chaperone that is member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.<ref>{{cite web | title = Entrez Gene: TCP1 t-complex 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6950| accessdate = }}</ref>
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==References==
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==Further reading==
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| citations =
*{{cite journal | author=Horwich AL, Willison KR |title=Protein folding in the cell: functions of two families of molecular chaperone, hsp 60 and TF55-TCP1. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=339 |issue= 1289 |pages= 313-25; discussion 325-6 |year= 1993 |pmid= 8098536 |doi= 10.1098/rstb.1993.0030 }}
*{{cite journal | author=Burston SG, Clarke AR |title=Molecular chaperones: physical and mechanistic properties. |journal=Essays Biochem. |volume=29 |issue= |pages= 125-36 |year= 1997 |pmid= 9189717 |doi= }}
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- INFO: Beginning work on TP53BP1... {November 8, 2007 1:06:52 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TP53BP1 image.jpg {November 8, 2007 1:07:54 PM PST}
- CREATE: Found no pages, creating new page. {November 8, 2007 1:08:11 PM PST}
- CREATED: Created new protein page: TP53BP1 {November 8, 2007 1:08:25 PM PST}
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