Log page index: User:ProteinBoxBot/PBB_Log_Index
Protein Status Quick Log - Date: 04:31, 10 November 2007 (UTC)[edit]
Proteins without matches (22)[edit]
Proteins with a High Potential Match (3)[edit]
Created (11)[edit]
Manual Inspection (Page not found) (14)[edit]
Protein Status Grid - Date: 04:31, 10 November 2007 (UTC)[edit]
Vebose Log - Date: 04:31, 10 November 2007 (UTC)[edit]
- INFO: Beginning work on ADAM12... {November 9, 2007 8:14:19 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 8:15:50 PM PST}
- CREATED: Created new protein page: ADAM12 {November 9, 2007 8:15:58 PM PST}
- INFO: Beginning work on ADAM15... {November 9, 2007 8:19:26 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 8:19:59 PM PST}
- CREATED: Created new protein page: ADAM15 {November 9, 2007 8:20:07 PM PST}
- INFO: Beginning work on AP1M1... {November 9, 2007 8:20:07 PM PST}
- UPLOAD: Added new Image to wiki:
{November 9, 2007 8:20:44 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 8:21:01 PM PST}
- CREATED: Created new protein page: AP1M1 {November 9, 2007 8:21:08 PM PST}
- INFO: Beginning work on BNIP3... {November 9, 2007 7:58:03 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein BNIP3 image.jpg {November 9, 2007 7:58:55 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 7:59:06 PM PST}
- CREATED: Created new protein page: BNIP3 {November 9, 2007 7:59:17 PM PST}
- INFO: Beginning work on CCL22... {November 9, 2007 8:05:20 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:06:09 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Chemokine (C-C motif) ligand 22
| HGNCid = 10621
| Symbol = CCL22
| AltSymbols =; MDC; A-152E5.1; ABCD-1; DC/B-CK; MGC34554; SCYA22; STCP-1
| OMIM = 602957
| ECnumber =
| Homologene = 7529
| MGIid = 1306779
| GeneAtlas_image1 = PBB_GE_CCL22_207861_at_tn.png
| Function = {{GNF_GO|id=GO:0008009 |text = chemokine activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0009615 |text = response to virus}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6367
| Hs_Ensembl = ENSG00000102962
| Hs_RefseqProtein = NP_002981
| Hs_RefseqmRNA = NM_002990
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 16
| Hs_GenLoc_start = 55950219
| Hs_GenLoc_end = 55957600
| Hs_Uniprot = O00626
| Mm_EntrezGene = 20299
| Mm_Ensembl = ENSMUSG00000031779
| Mm_RefseqmRNA = NM_009137
| Mm_RefseqProtein = NP_033163
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 8
| Mm_GenLoc_start = 97634719
| Mm_GenLoc_end = 97640698
| Mm_Uniprot = Q546S6
}}
}}
'''Chemokine (C-C motif) ligand 22''', also known as '''CCL22''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology.<ref>{{cite web | title = Entrez Gene: CCL22 chemokine (C-C motif) ligand 22| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6367| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Robertson MJ |title=Role of chemokines in the biology of natural killer cells. |journal=J. Leukoc. Biol. |volume=71 |issue= 2 |pages= 173-83 |year= 2002 |pmid= 11818437 |doi= }}
*{{cite journal | author=Gear AR, Camerini D |title=Platelet chemokines and chemokine receptors: linking hemostasis, inflammation, and host defense. |journal=Microcirculation (New York, N.Y. : 1994) |volume=10 |issue= 3-4 |pages= 335-50 |year= 2003 |pmid= 12851650 |doi= 10.1038/sj.mn.7800198 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on CD83... {November 9, 2007 8:21:08 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 8:21:44 PM PST}
- CREATED: Created new protein page: CD83 {November 9, 2007 8:21:51 PM PST}
- INFO: Beginning work on CUL4A... {November 9, 2007 8:17:17 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein CUL4A image.jpg {November 9, 2007 8:18:10 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 8:18:19 PM PST}
- CREATED: Created new protein page: CUL4A {November 9, 2007 8:18:27 PM PST}
- INFO: Beginning work on IKBKE... {November 9, 2007 8:21:51 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:23:06 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
| HGNCid = 14552
| Symbol = IKBKE
| AltSymbols =; IKK-i; IKKE; IKKI; KIAA0151; MGC125294; MGC125295; MGC125297
| OMIM = 605048
| ECnumber =
| Homologene = 23168
| MGIid = 1929612
| GeneAtlas_image1 = PBB_GE_IKBKE_214398_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_IKBKE_204549_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004704 |text = NF-kappaB-inducing kinase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008384 |text = IkappaB kinase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 9641
| Hs_Ensembl = ENSG00000143466
| Hs_RefseqProtein = NP_054721
| Hs_RefseqmRNA = NM_014002
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 204710414
| Hs_GenLoc_end = 204736846
| Hs_Uniprot = Q14164
| Mm_EntrezGene = 56489
| Mm_Ensembl = ENSMUSG00000042349
| Mm_RefseqmRNA = NM_019777
| Mm_RefseqProtein = NP_062751
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 1
| Mm_GenLoc_start = 133082148
| Mm_GenLoc_end = 133107109
| Mm_Uniprot = Q5DU46
}}
}}
'''Inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon''', also known as '''IKBKE''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Mercurio AM |title=Invasive skin carcinoma--Ras and alpha6beta4 integrin lead the way. |journal=Cancer Cell |volume=3 |issue= 3 |pages= 201-2 |year= 2003 |pmid= 12676577 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on PRDX2... {November 9, 2007 8:11:52 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein PRDX2 image.jpg {November 9, 2007 8:12:26 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:12:50 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_PRDX2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1qmv.
| PDB = {{PDB2|1qmv}}
| Name = Peroxiredoxin 2
| HGNCid = 9353
| Symbol = PRDX2
| AltSymbols =; PRP; MGC4104; NKEFB; PRXII; TDPX1; TSA
| OMIM = 600538
| ECnumber =
| Homologene = 21182
| MGIid = 109486
| GeneAtlas_image1 = PBB_GE_PRDX2_39729_at_tn.png
| Function = {{GNF_GO|id=GO:0008379 |text = thioredoxin peroxidase activity}} {{GNF_GO|id=GO:0016209 |text = antioxidant activity}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0051920 |text = peroxiredoxin activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006916 |text = anti-apoptosis}} {{GNF_GO|id=GO:0006979 |text = response to oxidative stress}} {{GNF_GO|id=GO:0042981 |text = regulation of apoptosis}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7001
| Hs_Ensembl = ENSG00000167815
| Hs_RefseqProtein = NP_859427
| Hs_RefseqmRNA = NM_181737
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 19
| Hs_GenLoc_start = 12768635
| Hs_GenLoc_end = 12773694
| Hs_Uniprot = P32119
| Mm_EntrezGene = 21672
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_011563
| Mm_RefseqProtein = NP_035693
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Peroxiredoxin 2''', also known as '''PRDX2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein may play an antioxidant protective role in cells, and may contribute to the antiviral activity of CD8(+) T-cells. This protein may have a proliferative effect and play a role in cancer development or progression. The crystal structure of this protein has been resolved to 2.7 angstroms. Transcript variants encoding distinct isoforms have been identified for this gene.<ref>{{cite web | title = Entrez Gene: PRDX2 peroxiredoxin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7001| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RDX... {November 9, 2007 7:59:17 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein RDX image.jpg {November 9, 2007 8:00:44 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:00:52 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RDX_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gc6.
| PDB = {{PDB2|1gc6}}, {{PDB2|1gc7}}, {{PDB2|1j19}}, {{PDB2|2d10}}, {{PDB2|2d11}}, {{PDB2|2d2q}}, {{PDB2|2yvc}}
| Name = Radixin
| HGNCid = 9944
| Symbol = RDX
| AltSymbols =;
| OMIM = 179410
| ECnumber =
| Homologene = 37707
| MGIid = 97887
| GeneAtlas_image1 = PBB_GE_RDX_204969_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_RDX_212397_at_tn.png
| GeneAtlas_image3 = PBB_GE_RDX_212398_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005902 |text = microvillus}} {{GNF_GO|id=GO:0015629 |text = actin cytoskeleton}}
| Process = {{GNF_GO|id=GO:0007016 |text = cytoskeletal anchoring}} {{GNF_GO|id=GO:0030033 |text = microvillus biogenesis}} {{GNF_GO|id=GO:0045176 |text = apical protein localization}} {{GNF_GO|id=GO:0051016 |text = barbed-end actin filament capping}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5962
| Hs_Ensembl = ENSG00000137710
| Hs_RefseqProtein = NP_002897
| Hs_RefseqmRNA = NM_002906
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 109605378
| Hs_GenLoc_end = 109672647
| Hs_Uniprot = P35241
| Mm_EntrezGene = 19684
| Mm_Ensembl = ENSMUSG00000032050
| Mm_RefseqmRNA = NM_009041
| Mm_RefseqProtein = NP_033067
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 9
| Mm_GenLoc_start = 51799393
| Mm_GenLoc_end = 51841094
| Mm_Uniprot = Q3TH46
}}
}}
'''Radixin''', also known as '''RDX''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Radixin is a cytoskeletal protein that may be important in linking actin to the plasma membrane. It is highly similar in sequence to both ezrin and moesin. The radixin gene has been localized by fluorescence in situ hybridization to 11q23. A truncated version representing a pseudogene (RDXP2) was assigned to Xp21.3. Another pseudogene that seemed to lack introns (RDXP1) was mapped to 11p by Southern and PCR analyses.<ref>{{cite web | title = Entrez Gene: RDX radixin| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5962| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Hoeflich KP, Ikura M |title=Radixin: cytoskeletal adopter and signaling protein. |journal=Int. J. Biochem. Cell Biol. |volume=36 |issue= 11 |pages= 2131-6 |year= 2005 |pmid= 15313460 |doi= 10.1016/j.biocel.2003.11.018 }}
*{{cite journal | author=Matarrese P, Malorni W |title=Human immunodeficiency virus (HIV)-1 proteins and cytoskeleton: partners in viral life and host cell death. |journal=Cell Death Differ. |volume=12 Suppl 1 |issue= |pages= 932-41 |year= 2006 |pmid= 15818415 |doi= 10.1038/sj.cdd.4401582 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RFC1... {November 9, 2007 8:00:52 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:02:00 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Replication factor C (activator 1) 1, 145kDa
| HGNCid = 9969
| Symbol = RFC1
| AltSymbols =; A1; MGC51786; MHCBFB; PO-GA; RECC1; RFC; RFC140
| OMIM = 102579
| ECnumber =
| Homologene = 2187
| MGIid = 97891
| GeneAtlas_image1 = PBB_GE_RFC1_208021_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_RFC1_209085_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008047 |text = enzyme activator activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0017111 |text = nucleoside-triphosphatase activity}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005663 |text = DNA replication factor C complex}}
| Process = {{GNF_GO|id=GO:0006261 |text = DNA-dependent DNA replication}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007004 |text = telomere maintenance via telomerase}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 5981
| Hs_Ensembl = ENSG00000035928
| Hs_RefseqProtein = NP_002904
| Hs_RefseqmRNA = NM_002913
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 4
| Hs_GenLoc_start = 38965471
| Hs_GenLoc_end = 39044390
| Hs_Uniprot = P35251
| Mm_EntrezGene = 19687
| Mm_Ensembl = ENSMUSG00000029191
| Mm_RefseqmRNA = NM_011258
| Mm_RefseqProtein = NP_035388
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 5
| Mm_GenLoc_start = 65542198
| Mm_GenLoc_end = 65598665
| Mm_Uniprot = Q3UJT6
}}
}}
'''Replication factor C (activator 1) 1, 145kDa''', also known as '''RFC1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is the large subunit of replication factor C, which is a five subunit DNA polymerase accessory protein. Replication factor C is a DNA-dependent ATPase that is required for eukaryotic DNA replication and repair. The protein acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It also may have a role in telomere stability.<ref>{{cite web | title = Entrez Gene: RFC1 replication factor C (activator 1) 1, 145kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5981| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RNASE2... {November 9, 2007 8:02:00 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein RNASE2 image.jpg {November 9, 2007 8:02:34 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:02:47 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_RNASE2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gqv.
| PDB = {{PDB2|1gqv}}, {{PDB2|1hi2}}, {{PDB2|1hi3}}, {{PDB2|1hi4}}, {{PDB2|1hi5}}, {{PDB2|1k2a}}, {{PDB2|2bex}}, {{PDB2|2bzz}}, {{PDB2|2c01}}, {{PDB2|2c02}}, {{PDB2|2c05}}
| Name = Ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
| HGNCid = 10045
| Symbol = RNASE2
| AltSymbols =; EDN; RNS2
| OMIM = 131410
| ECnumber =
| Homologene = 68284
| MGIid = 1858238
| GeneAtlas_image1 = PBB_GE_RNASE2_206111_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0004519 |text = endonuclease activity}} {{GNF_GO|id=GO:0004522 |text = pancreatic ribonuclease activity}} {{GNF_GO|id=GO:0004540 |text = ribonuclease activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042613 |text = MHC class II protein complex}}
| Process = {{GNF_GO|id=GO:0002504 |text = antigen processing and presentation of peptide or polysaccharide antigen via MHC class II}} {{GNF_GO|id=GO:0006401 |text = RNA catabolic process}} {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006955 |text = immune response}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6036
| Hs_Ensembl = ENSG00000169385
| Hs_RefseqProtein = NP_002925
| Hs_RefseqmRNA = NM_002934
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 14
| Hs_GenLoc_start = 20493470
| Hs_GenLoc_end = 20494434
| Hs_Uniprot = P10153
| Mm_EntrezGene = 53877
| Mm_Ensembl =
| Mm_RefseqmRNA = NM_001017422
| Mm_RefseqProtein = NP_001017422
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)''', also known as '''RNASE2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Rosenberg HF, Domachowske JB |title=Eosinophils, ribonucleases and host defense: solving the puzzle. |journal=Immunol. Res. |volume=20 |issue= 3 |pages= 261-74 |year= 2000 |pmid= 10741866 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RRM1... {November 9, 2007 8:02:47 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:03:48 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Ribonucleotide reductase M1 polypeptide
| HGNCid = 10451
| Symbol = RRM1
| AltSymbols =; R1; RIR1; RR1
| OMIM = 180410
| ECnumber =
| Homologene = 806
| MGIid = 98180
| GeneAtlas_image1 = PBB_GE_RRM1_201477_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_RRM1_201476_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004748 |text = ribonucleoside-diphosphate reductase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}}
| Component = {{GNF_GO|id=GO:0005971 |text = ribonucleoside-diphosphate reductase complex}}
| Process = {{GNF_GO|id=GO:0006260 |text = DNA replication}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6240
| Hs_Ensembl = ENSG00000167325
| Hs_RefseqProtein = NP_001024
| Hs_RefseqmRNA = NM_001033
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 4072587
| Hs_GenLoc_end = 4116681
| Hs_Uniprot = P23921
| Mm_EntrezGene = 20133
| Mm_Ensembl = ENSMUSG00000030978
| Mm_RefseqmRNA = NM_009103
| Mm_RefseqProtein = NP_033129
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 7
| Mm_GenLoc_start = 102315638
| Mm_GenLoc_end = 102342746
| Mm_Uniprot = Q05DU8
}}
}}
'''Ribonucleotide reductase M1 polypeptide''', also known as '''RRM1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = This gene encodes one of two non-identical subunits which constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. This gene is oriented in a head-to-tail configuration with the stromal interaction molecule 1 gene (STIM1), with the 3' end of STIM1 situated 1.6 kb from the 5' end of this gene.<ref>{{cite web | title = Entrez Gene: RRM1 ribonucleotide reductase M1 polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6240| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on RUVBL1... {November 9, 2007 8:18:27 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein RUVBL1 image.jpg {November 9, 2007 8:18:59 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 8:19:19 PM PST}
- CREATED: Created new protein page: RUVBL1 {November 9, 2007 8:19:26 PM PST}
- INFO: Beginning work on S100A2... {November 9, 2007 8:03:48 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 8:04:31 PM PST}
- CREATED: Created new protein page: S100A2 {November 9, 2007 8:04:39 PM PST}
- INFO: Beginning work on SCP2... {November 9, 2007 8:04:39 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein SCP2 image.jpg {November 9, 2007 8:04:53 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 8:05:12 PM PST}
- CREATED: Created new protein page: SCP2 {November 9, 2007 8:05:20 PM PST}
- INFO: Beginning work on SEMG1... {November 9, 2007 8:06:09 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:06:45 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Semenogelin I
| HGNCid = 10742
| Symbol = SEMG1
| AltSymbols =; MGC14719; SEMG; SGI
| OMIM = 182140
| ECnumber =
| Homologene =
| MGIid =
| GeneAtlas_image1 = PBB_GE_SEMG1_206442_at_tn.png
| Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0030141 |text = secretory granule}}
| Process = {{GNF_GO|id=GO:0007320 |text = insemination}} {{GNF_GO|id=GO:0019953 |text = sexual reproduction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6406
| Hs_Ensembl = ENSG00000124233
| Hs_RefseqProtein = NP_002998
| Hs_RefseqmRNA = NM_003007
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 20
| Hs_GenLoc_start = 43269052
| Hs_GenLoc_end = 43271827
| Hs_Uniprot = P04279
| Mm_EntrezGene =
| Mm_Ensembl =
| Mm_RefseqmRNA =
| Mm_RefseqProtein =
| Mm_GenLoc_db =
| Mm_GenLoc_chr =
| Mm_GenLoc_start =
| Mm_GenLoc_end =
| Mm_Uniprot =
}}
}}
'''Semenogelin I''', also known as '''SEMG1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. The prostate-specific antigen (PSA) protease processes this protein into smaller peptides, with each possibly having a separate function. The proteolysis process breaks down the gel matrix and allows the spermatozoa to move more freely. Two transcript variants encoding different isoforms have been found for this gene.<ref>{{cite web | title = Entrez Gene: SEMG1 semenogelin I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6406| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Robert M, Gagnon C |title=Semenogelin I: a coagulum forming, multifunctional seminal vesicle protein. |journal=Cell. Mol. Life Sci. |volume=55 |issue= 6-7 |pages= 944-60 |year= 1999 |pmid= 10412373 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SFTPA2... {November 9, 2007 8:06:45 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:07:11 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Surfactant, pulmonary-associated protein A2
| HGNCid = 10799
| Symbol = SFTPA2
| AltSymbols =; SP-A1; COLEC5; SP-2A; SP-2A beta; SP-A1 beta; SP-A2; SPAII
| OMIM = 178642
| ECnumber =
| Homologene = 3946
| MGIid = 109518
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005529 |text = sugar binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006817 |text = phosphate transport}} {{GNF_GO|id=GO:0007585 |text = respiratory gaseous exchange}} {{GNF_GO|id=GO:0050828 |text = regulation of liquid surface tension}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6436
| Hs_Ensembl =
| Hs_RefseqProtein = NP_008857
| Hs_RefseqmRNA = NM_006926
| Hs_GenLoc_db =
| Hs_GenLoc_chr =
| Hs_GenLoc_start =
| Hs_GenLoc_end =
| Hs_Uniprot =
| Mm_EntrezGene = 20387
| Mm_Ensembl = ENSMUSG00000021789
| Mm_RefseqmRNA = NM_023134
| Mm_RefseqProtein = NP_075623
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 40040501
| Mm_GenLoc_end = 40045165
| Mm_Uniprot = Q9CQI1
}}
}}
'''Surfactant, pulmonary-associated protein A2''', also known as '''SFTPA2''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Floros J, Hoover RR |title=Genetics of the hydrophilic surfactant proteins A and D. |journal=Biochim. Biophys. Acta |volume=1408 |issue= 2-3 |pages= 312-22 |year= 1999 |pmid= 9813381 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SLC15A1... {November 9, 2007 8:07:58 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 8:08:53 PM PST}
- CREATED: Created new protein page: SLC15A1 {November 9, 2007 8:09:01 PM PST}
- INFO: Beginning work on SLC16A1... {November 9, 2007 8:09:01 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:10:46 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 16, member 1 (monocarboxylic acid transporter 1)
| HGNCid = 10922
| Symbol = SLC16A1
| AltSymbols =; MCT1; FLJ36745; MCT; MGC44475
| OMIM = 600682
| ECnumber =
| Homologene = 20662
| MGIid = 106013
| GeneAtlas_image1 = PBB_GE_SLC16A1_202236_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SLC16A1_202234_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_SLC16A1_202235_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0015130 |text = mevalonate transmembrane transporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0015355 |text = secondary active monocarboxylate transmembrane transporter activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0015711 |text = organic anion transport}} {{GNF_GO|id=GO:0015728 |text = mevalonate transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6566
| Hs_Ensembl = ENSG00000155380
| Hs_RefseqProtein = NP_003042
| Hs_RefseqmRNA = NM_003051
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 1
| Hs_GenLoc_start = 113255992
| Hs_GenLoc_end = 113300498
| Hs_Uniprot = P53985
| Mm_EntrezGene = 20501
| Mm_Ensembl = ENSMUSG00000032902
| Mm_RefseqmRNA = NM_009196
| Mm_RefseqProtein = NP_033222
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 3
| Mm_GenLoc_start = 104767729
| Mm_GenLoc_end = 104787523
| Mm_Uniprot = Q3TIU1
}}
}}
'''Solute carrier family 16, member 1 (monocarboxylic acid transporter 1)''', also known as '''SLC16A1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Bonen A |title=The expression of lactate transporters (MCT1 and MCT4) in heart and muscle. |journal=Eur. J. Appl. Physiol. |volume=86 |issue= 1 |pages= 6-11 |year= 2002 |pmid= 11820324 |doi= }}
*{{cite journal | author=Halestrap AP, Meredith D |title=The SLC16 gene family-from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. |journal=Pflugers Arch. |volume=447 |issue= 5 |pages= 619-28 |year= 2004 |pmid= 12739169 |doi= 10.1007/s00424-003-1067-2 }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SLC1A3... {November 9, 2007 8:07:11 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:07:58 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 1 (glial high affinity glutamate transporter), member 3
| HGNCid = 10941
| Symbol = SLC1A3
| AltSymbols =; EA6; EAAT1; FLJ25094; GLAST; GLAST1
| OMIM = 600111
| ECnumber =
| Homologene = 20882
| MGIid = 99917
| GeneAtlas_image1 = PBB_GE_SLC1A3_202800_at_tn.png
| Function = {{GNF_GO|id=GO:0005313 |text = L-glutamate transmembrane transporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0017153 |text = sodium:dicarboxylate symporter activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0042995 |text = cell projection}} {{GNF_GO|id=GO:0043025 |text = cell soma}}
| Process = {{GNF_GO|id=GO:0001504 |text = neurotransmitter uptake}} {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006835 |text = dicarboxylic acid transport}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0015813 |text = glutamate transport}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6507
| Hs_Ensembl = ENSG00000079215
| Hs_RefseqProtein = NP_004163
| Hs_RefseqmRNA = NM_004172
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 5
| Hs_GenLoc_start = 36642446
| Hs_GenLoc_end = 36724193
| Hs_Uniprot = P43003
| Mm_EntrezGene = 20512
| Mm_Ensembl = ENSMUSG00000005360
| Mm_RefseqmRNA = NM_148938
| Mm_RefseqProtein = NP_683740
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 15
| Mm_GenLoc_start = 8581335
| Mm_GenLoc_end = 8657945
| Mm_Uniprot = Q543U3
}}
}}
'''Solute carrier family 1 (glial high affinity glutamate transporter), member 3''', also known as '''SLC1A3''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Glutamate and aspartate are excitatory neurotransmitters that have been implicated in a number of pathologic states of the nervous system. Accumulation of extracellular excitatory amino acids can be cytotoxic and may also lower the seizure threshold in epilepsy. EAAT1 (SLC1A3) is a member of a family of high-affinity sodium-dependent transporter molecules that regulate neurotransmitter concentrations at the excitatory glutamatergic synapses of the mammalian central nervous system (Kirschner et al., 1994).[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6507| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SMC1A... {November 9, 2007 8:15:58 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:17:16 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Structural maintenance of chromosomes 1A
| HGNCid = 11111
| Symbol = SMC1A
| AltSymbols =; DKFZp686L19178; DXS423E; KIAA0178; MGC138332; SB1.8; SMC1; SMC1L1; SMC1alpha; SMCB
| OMIM = 300040
| ECnumber =
| Homologene = 4597
| MGIid = 1344345
| GeneAtlas_image1 = PBB_GE_SMC1A_201589_at_tn.png
| GeneAtlas_image2 = PBB_GE_SMC1A_217555_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0003777 |text = microtubule motor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016887 |text = ATPase activity}} {{GNF_GO|id=GO:0046982 |text = protein heterodimerization activity}}
| Component = {{GNF_GO|id=GO:0000776 |text = kinetochore}} {{GNF_GO|id=GO:0000794 |text = condensed nuclear chromosome}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}} {{GNF_GO|id=GO:0008280 |text = cohesin core heterodimer}}
| Process = {{GNF_GO|id=GO:0000075 |text = cell cycle checkpoint}} {{GNF_GO|id=GO:0006259 |text = DNA metabolic process}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007052 |text = mitotic spindle organization and biogenesis}} {{GNF_GO|id=GO:0007059 |text = chromosome segregation}} {{GNF_GO|id=GO:0007064 |text = mitotic sister chromatid cohesion}} {{GNF_GO|id=GO:0007126 |text = meiosis}} {{GNF_GO|id=GO:0009314 |text = response to radiation}} {{GNF_GO|id=GO:0042770 |text = DNA damage response, signal transduction}} {{GNF_GO|id=GO:0051276 |text = chromosome organization and biogenesis}} {{GNF_GO|id=GO:0051301 |text = cell division}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 8243
| Hs_Ensembl = ENSG00000072501
| Hs_RefseqProtein = NP_006297
| Hs_RefseqmRNA = NM_006306
| Hs_GenLoc_db =
| Hs_GenLoc_chr = X
| Hs_GenLoc_start = 53417795
| Hs_GenLoc_end = 53466343
| Hs_Uniprot = Q14683
| Mm_EntrezGene = 24061
| Mm_Ensembl = ENSMUSG00000041133
| Mm_RefseqmRNA = NM_019710
| Mm_RefseqProtein = NP_062684
| Mm_GenLoc_db =
| Mm_GenLoc_chr = X
| Mm_GenLoc_start = 147357144
| Mm_GenLoc_end = 147402683
| Mm_Uniprot = A0JLM6
}}
}}
'''Structural maintenance of chromosomes 1A''', also known as '''SMC1A''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2 or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation.<ref>{{cite web | title = Entrez Gene: SMC1A structural maintenance of chromosomes 1A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8243| accessdate = }}</ref>
}}
==References==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on SSRP1... {November 9, 2007 8:10:46 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:11:52 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Structure specific recognition protein 1
| HGNCid = 11327
| Symbol = SSRP1
| AltSymbols =; FACT; FACT80; T160
| OMIM = 604328
| ECnumber =
| Homologene = 2370
| MGIid = 107912
| GeneAtlas_image1 = PBB_GE_SSRP1_200957_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SSRP1_200956_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0000785 |text = chromatin}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}}
| Process = {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006281 |text = DNA repair}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 6749
| Hs_Ensembl = ENSG00000149136
| Hs_RefseqProtein = NP_003137
| Hs_RefseqmRNA = NM_003146
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 11
| Hs_GenLoc_start = 56850036
| Hs_GenLoc_end = 56859927
| Hs_Uniprot = Q08945
| Mm_EntrezGene = 20833
| Mm_Ensembl = ENSMUSG00000027067
| Mm_RefseqmRNA = NM_182990
| Mm_RefseqProtein = NP_892035
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 2
| Mm_GenLoc_start = 84838111
| Mm_GenLoc_end = 84847948
| Mm_Uniprot = Q05DR5
}}
}}
'''Structure specific recognition protein 1''', also known as '''SSRP1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63.<ref>{{cite web | title = Entrez Gene: SSRP1 structure specific recognition protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6749| accessdate = }}</ref>
}}
==References==
{{reflist}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on TNNC1... {November 9, 2007 8:12:50 PM PST}
- UPLOAD: Added new Image to wiki: File:PBB Protein TNNC1 image.jpg {November 9, 2007 8:13:24 PM PST}
- AMBIGUITY: Did not locate an acceptable page to update. {November 9, 2007 8:13:37 PM PST}
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_TNNC1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1aj4.
| PDB = {{PDB2|1aj4}}, {{PDB2|1ap4}}, {{PDB2|1dtl}}, {{PDB2|1fi5}}, {{PDB2|1ih0}}, {{PDB2|1j1d}}, {{PDB2|1j1e}}, {{PDB2|1la0}}, {{PDB2|1lxf}}, {{PDB2|1mxl}}, {{PDB2|1ozs}}, {{PDB2|1r2u}}, {{PDB2|1r6p}}, {{PDB2|1sbj}}, {{PDB2|1scv}}, {{PDB2|1spy}}, {{PDB2|1wrk}}, {{PDB2|1wrl}}, {{PDB2|2ctn}}, {{PDB2|3ctn}}
| Name = Troponin C type 1 (slow)
| HGNCid = 11943
| Symbol = TNNC1
| AltSymbols =; TNC; TNNC
| OMIM = 191040
| ECnumber =
| Homologene = 55728
| MGIid = 98779
| GeneAtlas_image1 = PBB_GE_TNNC1_209904_at_tn.png
| Function = {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006937 |text = regulation of muscle contraction}}
| Orthologs = {{GNF_Ortholog_box
| Hs_EntrezGene = 7134
| Hs_Ensembl = ENSG00000114854
| Hs_RefseqProtein = NP_003271
| Hs_RefseqmRNA = NM_003280
| Hs_GenLoc_db =
| Hs_GenLoc_chr = 3
| Hs_GenLoc_start = 52460158
| Hs_GenLoc_end = 52463098
| Hs_Uniprot = P63316
| Mm_EntrezGene = 21924
| Mm_Ensembl = ENSMUSG00000021909
| Mm_RefseqmRNA = NM_009393
| Mm_RefseqProtein = NP_033419
| Mm_GenLoc_db =
| Mm_GenLoc_chr = 14
| Mm_GenLoc_start = 30037321
| Mm_GenLoc_end = 30040720
| Mm_Uniprot = P19123
}}
}}
'''Troponin C type 1 (slow)''', also known as '''TNNC1''', is a human [[gene]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
| summary_text =
}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal | author=Gomes AV, Potter JD |title=Cellular and molecular aspects of familial hypertrophic cardiomyopathy caused by mutations in the cardiac troponin I gene. |journal=Mol. Cell. Biochem. |volume=263 |issue= 1-2 |pages= 99-114 |year= 2005 |pmid= 15524171 |doi= }}
}}
{{refend}}
{{protein-stub}}
- INFO: Beginning work on USH2A... {November 9, 2007 8:13:37 PM PST}
- CREATE: Found no pages, creating new page. {November 9, 2007 8:14:12 PM PST}
- CREATED: Created new protein page: USH2A {November 9, 2007 8:14:19 PM PST}
end log.
