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Zofenopril AHFS /Drugs.com International Drug Names Routes of administration Oral ATC code
(2S ,4S )-1-[(2S )-3-benzoylsulfanyl-2-methylpropanoyl]-4-phenylsulfanylpyrrolidine-2-carboxylic acid
CAS Number PubChem CID IUPHAR/BPS ChemSpider UNII KEGG ChEBI ChEMBL CompTox Dashboard (EPA ) Formula C 22 H 23 N O 4 S 2 Molar mass 429.552 g/mol g·mol−1 3D model (JSmol )
O=C(N2[C@H](C(=O)O)C[C@H](Sc1ccccc1)C2)[C@H](C)CSC(=O)c3ccccc3
InChI=1S/C22H23NO4S2/c1-15(14-28-22(27)16-8-4-2-5-9-16)20(24)23-13-18(12-19(23)21(25)26)29-17-10-6-3-7-11-17/h2-11,15,18-19H,12-14H2,1H3,(H,25,26)/t15-,18+,19+/m1/s1
N Key:IAIDUHCBNLFXEF-MNEFBYGVSA-N
N
N Y (what is this?) (verify)
Zofenopril (INN ) is a medication that protects the heart and helps reduce high blood pressure . It is an angiotensin-converting enzyme (ACE) inhibitor .[ 1]
In small studies, zofenopril appeared significantly more effective in reducing hypertension than two older antihypertensive drugs , atenolol and enalapril , and was associated with fewer adverse effects .[ 2] [ 3]
Zofenoprilat — the active metabolite of zofenopril
References
^ Ambrosioni E (2007). "Defining the role of zofenopril in the management of hypertension and ischemic heart disorders". Am J Cardiovasc Drugs . 7 (1): 17–24. doi :10.2165/00129784-200707010-00002 . PMID 17355163 .
^ Nilsson P (October 2007). "Antihypertensive efficacy of zofenopril compared with atenolol in patients with mild to moderate hypertension". Blood Press Suppl . 2 : 25–30. PMID 18046976 .
^ Mallion JM (October 2007). "An evaluation of the initial and long-term antihypertensive efficacy of zofenopril compared with enalapril in mild to moderate hypertension". Blood Press Suppl . 2 : 13–8. PMID 18046974 .
ACE inhibitors ("-pril")
Sulfhydryl-containing : Captopril
Rentiapril
Zofenopril (+nebivolol )
Dicarboxylate-containing : Enalapril # (+lercanidipine , +nitrendipine )
Benazepril (+amlodipine , +pimobendan )
Cilazapril
Delapril (+manidipine )
Imidapril
Lisinopril (+amlodipine , +HCT )
Moexipril
Perindopril (+amlodipine , +bisoprolol , +indapamide , +amlodipine and indapamide , +bisoprolol and amlodipine , +bisoprolol, amlodipine, and indapamide )
Quinapril (+HCT )
Ramipril (+amlodipine , +amlodipine and HCT , +bisoprolol , +felodipine )
Spirapril
Temocapril
Trandolapril (+verapamil )
Phosphonate-containing : Ceronapril
Fosinopril (+HCT )
Other/ungrouped: Alacepril
AIIRAs ("-sartan")
Azilsartan
Candesartan (+amlodipine , +amlodipine and HCT )
Eprosartan
Fimasartan
Irbesartan (+amlodipine , +amlodipine and HCT , +HCT )
Losartan (+amlodipine , +HCT )
Olmesartan (+amlodipine , +amlodipine and HCT , +HCT )
Tasosartan §
Telmisartan (+amlodipine , +amlodipine and HCT , +HCT )
Valsartan (+aliskiren , +amlodipine , +amlodipine and HCT , +HCT , +lercanidipine , +nebivolol , +sacubitril )
Renin inhibitors ("-kiren")Dual ACE /NEP inhibitors Neprilysin inhibitorsOther