Amlodipine/valsartan

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Amlodipine/valsartan
Amlodipine.svg
Valsartan skeletal.svg
Combination of
Amlodipine Calcium channel blocker
Valsartan Angiotensin II receptor antagonist
Clinical data
Pregnancy
category
  • US: D (Evidence of risk)
Routes of
administration
Oral
ATC code
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
KEGG
  (verify)

Amlodipine/valsartan is of an oral blood pressure lowering combination drug which combines two medications in a film-coated tablet. It contains both amlodipine, a dihydropyridine-type calcium channel blocker, and valsartan, an angiotensin II receptor antagonist (ARB or A2RA); typically formulated as the benzenesulfonate salt. Meta-analysis has shown this combination to be well tolerated and effective for the reduction of blood pressure.[1]

The combination was originally patented by Novartis Pharmaceuticals under the brand name Exforge. The patent expired in September 2012.[2]

Amlodipine/valsartan is available in different dose preparations: 5 mg/80 mg, 5 mg/160 mg, 10 mg/160 mg, 5 mg/320 mg and 10/320 mg of amlodipine and valsartan, respectively.

The combination is also available with included hydrochlorothiazide, for patients who need a three drug regimen to manage their blood pressure.

References[edit]

  1. ^ Eckert, Siegfried; Freytag, Siegfried B.; Müller, Alfons; Klebs, Sven H. G. (2013). "Meta-analysis of three observational studies of amlodipine/valsartan in hypertensive patients with additional risk factors". Blood Pressure. 22 (sup1): 11–21. ISSN 0803-7051. doi:10.3109/08037051.2013.793891. 
  2. ^ "Generic Exforge HCT". Blood-pressure.emedtv.com. Retrieved 2012-03-05. 

External links[edit]