Fluoxetine: Difference between revisions

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'''Fluoxetine hydrochloride''' is an [[antidepressant]] [[Medication|drug]] used medically in the treatment of [[Clinical depression|depression]], [[body dysmorphic disorder]], [[obsessive-compulsive disorder]], [[bulimia nervosa]], [[anorexia nervosa]], [[premenstrual dysphoric disorder]], [[hypochondriasis]] and [[panic disorder]]. The drug was developed, manufactured and marketed by [[Eli Lilly and Company]], a Fortune 500 pharmaceutical corporation, prior to losing its patent protection and becoming eligible for mass [[generic drug|generic]] production in 2001.
'''Fluoxetine hydrochloride''' is an [[antidepressant]] [[Medication|drug]] used medically in the treatment of [[Clinical depression|depression]], [[body dysmorphic disorder]], [[obsessive-compulsive disorder]], [[bulimia nervosa]], [[anorexia nervosa]], [[premenstrual dysphoric disorder]], [[hypochondriasis]] and [[panic disorder]]. The drug was developed, manufactured and marketed by [[Eli Lilly and Company]], a Fortune 500 pharmaceutical corporation, prior to losing its patent protection and becoming eligible for mass [[generic drug|generic]] production in 2001.


Fluoxetine is an atypical [[Selective serotonin reuptake inhibitor|SSRI]], in that it has been found to also increase extracellular levels of dopamine and norepinephrine in the prefrontal cortex, in addition to those of serotonin. As such, this particular SSRI may be more effective at treating depression associated with a lack of motivation or energy.[http://www.socialfear.com/prozac_atypical_ssri.html]
Fluoxetine is an atypical [[Selective serotonin reuptake inhibitor|SSRI]], in that it has been found to also increase extracellular levels of dopamine and norepinephrine in the prefrontal cortex, in addition to those of serotonin. As such, this particular SSRI may be more effective at treating depression associated with a lack of motivation or energy.<ref>{{cite journal | last = Bymaster | first = Frank P. | authorlink = | coauthors = Wei Zhang et. al. | title = Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. | journal = J. Psychopharmacology (Berl) | volume = 160 | issue = 4 | pages = 353-361 | publisher = Springer Berlin / Heidelberg | date = April 2002 | url = http://www.socialfear.com/prozac_atypical_ssri.html | doi = 10.1007/s00213-001-0986-x | id = PMID 11919662 {{ISSN|1432-2072}} | accessdate = 2007-04-13}}</ref>


Fluoxetine was derived from the [[antihistamine]] [[diphenhydramine]], which had been found to inhibit [[reuptake]] of the [[neurotransmitter]] [[serotonin]].[http://www.psychosomaticmedicine.org/cgi/content/full/61/5/591]
Fluoxetine was derived from the [[antihistamine]] [[diphenhydramine]], which had been found to inhibit [[reuptake]] of the [[neurotransmitter]] [[serotonin]].<ref>{{cite journal | last = Domino | first = Edward F. | title = History of Modern Psychopharmacology: A Personal View With an Emphasis on Antidepressants | journal = J. Psychosom. Med. | volume = 61 | issue = 5 | pages = 591-598 | publisher = | date = September 1999 | url = http://www.psychosomaticmedicine.org/cgi/content/full/61/5/591 | id = PMID 10511010 | accessdate = 2007-04-13}}</ref>


==See also==
==See also==
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* [[Serotonin]]
* [[Serotonin]]
* [[SSRI discontinuation syndrome]]
* [[SSRI discontinuation syndrome]]

==References==
{{Reflist|2}}


==External links==
==External links==

Revision as of 05:51, 14 April 2007

"Prozac" redirects here. For other uses, see Prozac (disambiguation).
Fluoxetine
File:Fluoxetine-3D-vdW.png
Clinical data
License data
Routes of
administration		oral
ATC code
Legal status
Legal status
  • US: WARNING[1]
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability72%
peak at 6-8 hours
Protein binding94.5%
MetabolismHepatic
Elimination half-life1-3 days (acute); 4-6 days (chronic); Active metabolite Norfluoxetine 4-16 days (acute and chronic)
ExcretionKidneys 80%, Intestines 15%
Identifiers
  • N-methyl-3-phenyl-
    3-[4-(trifluoromethyl)phenoxy]-
    propan-1-amine
CAS Number
PubChem CID
DrugBank
CompTox Dashboard (EPA)
ECHA InfoCard100.125.370 Edit this at Wikidata
Chemical and physical data
FormulaC17H18F3NO
Molar mass309.3 (345.8 for •HCl) g·mol−1

Fluoxetine hydrochloride is an antidepressant drug used medically in the treatment of depression, body dysmorphic disorder, obsessive-compulsive disorder, bulimia nervosa, anorexia nervosa, premenstrual dysphoric disorder, hypochondriasis and panic disorder. The drug was developed, manufactured and marketed by Eli Lilly and Company, a Fortune 500 pharmaceutical corporation, prior to losing its patent protection and becoming eligible for mass generic production in 2001.

Fluoxetine is an atypical SSRI, in that it has been found to also increase extracellular levels of dopamine and norepinephrine in the prefrontal cortex, in addition to those of serotonin. As such, this particular SSRI may be more effective at treating depression associated with a lack of motivation or energy.[2]

Fluoxetine was derived from the antihistamine diphenhydramine, which had been found to inhibit reuptake of the neurotransmitter serotonin.[3]

See also

References

  1. ^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
  2. ^ Bymaster, Frank P. (April 2002). "Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex". J. Psychopharmacology (Berl). 160 (4). Springer Berlin / Heidelberg: 353–361. doi:10.1007/s00213-001-0986-x. PMID 11919662 ISSN 1432-2072. Retrieved 2007-04-13. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  3. ^ Domino, Edward F. (September 1999). "History of Modern Psychopharmacology: A Personal View With an Emphasis on Antidepressants". J. Psychosom. Med. 61 (5): 591–598. PMID 10511010. Retrieved 2007-04-13.

External links

Template:ChemicalSources

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