Dimetacrine

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Dimetacrine
Dimetacrine.svg
Systematic (IUPAC) name
3-(9,9-dimethylacridin-10-yl)-N,N-dimethyl-propan-1-amine
Clinical data
Legal status
  • Prescription only
Routes Oral
Identifiers
CAS number 4757-55-5
ATC code N06AA18
PubChem CID 94280
ChemSpider 85085
UNII O341NY501N YesY
KEGG D02565
Chemical data
Formula C20H26N2 
Mol. mass 294.43 g/mol

Dimetacrine (Istonil, Istonyl, Linostil, Miroistonil), also known as dimethacrine and acripramine, is a tricyclic antidepressant (TCA) used in Europe and formerly in Japan for the treatment of depression.[1][2][3][4][5] It has imipramine-like effects; though, in a double-blind clinical trial against imipramine, dimetacrine was found to have lower efficacy in comparison and produced more weight loss and abnormal liver tests.[6][7] Little is known about the pharmacology of dimetacrine, but it can be inferred that it acts in a similar manner to other TCAs. If this is indeed the case, dimetacrine may induce severe cardiac toxicity in overdose (a side effect unique to the tricyclic class of antidepressants).

Synthesis[edit]

GB 933875 

See also[edit]

References[edit]

  1. ^ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8. 
  2. ^ Affective disorders: perspective on ... - Google Books. 
  3. ^ José Miguel Vela; Helmut Buschmann; Jörg Holenz; Antonio Párraga; Antoni Torrens (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. ISBN 3-527-31058-4. 
  4. ^ Taen S, Pöldinger W (December 1966). "[Dimethacrine (istonil), an acridane derivative with the antidepressive action]". Schweizerische Medizinische Wochenschrift (in German) 96 (48): 1616–20. PMID 6008540. 
  5. ^ Meyer R (May 1968). "[Contribution to the clinical evaluation of the antidepressive effect of dimethacrine (Istonil)]". Praxis (in German) 57 (20): 721–3. PMID 5756370. 
  6. ^ Abuzzahab FS (November 1973). "A double-blind investigation of dimethacrine versus imipramine in hospitalized depressive states". International Journal of Clinical Pharmacology, Therapy and Toxicology 8 (3): 244–53. PMID 4149236. 
  7. ^ Mutschler, Ernst; Derendorf, Hartmut (1995). Drug actions: basic principles and therapeutic aspects. Stuttgart, Germany: Medpharm Scientific Pub. ISBN 0-8493-7774-9. Retrieved January 30, 2013.