Keratin 10: Difference between revisions

KRT10
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	4F1Z, 3ASW, 4ZRY
Identifiers
Aliases	KRT10, BCIE, BIE, CK10, EHK, K10, KPP, keratin 10
External IDs	OMIM: 148080 GeneCards: KRT10
Gene location (Human)
Chr.	Chromosome 17 (human)
End	40,822,614 bp
RNA expression pattern
	Top expressed in
	vulva; ; nipple; ; human penis; ; skin of abdomen; ; gums; ; sperm; ; parotid gland; ; palpebral conjunctiva; ; vagina; ; amniotic fluid;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	structural molecule activity; structural constituent of skin epidermis; protein heterodimerization activity; protein binding;
Cellular component	cytoplasm; extracellular exosome; intermediate filament; membrane; nucleus; extracellular space; cytosol; cornified envelope; extracellular region; cell surface;
Biological process	keratinocyte differentiation; keratinization; cornification; peptide cross-linking; positive regulation of epidermis development; protein heterotetramerization;
	Sources:Amigo / QuickGO
Orthologs
	3858
	n/a
	ENSG00000186395
	n/a
	P13645
	n/a
	NM_000421; NM_001379366
	n/a
	NP_000412; NP_001366295
	n/a
	Wikidata
View/Edit Human

Browse history interactively

← Previous edit Next edit →

Content deleted Content added

VisualWikitext

Inline

Revision as of 03:28, 18 February 2008

{{protein Template:PBB Controls

Keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris), also known as KRT10, is a human gene.^[3]

Template:PBB Summary

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000186395 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: KRT10 keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris)".

@@ Line 1: / Line 1: @@
 {{protein
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
-| Name = keratin 10
+{{PBB_Controls
-| caption =
-| image =
+| update_page = yes
+| require_manual_inspection = no
-| width =
+| update_protein_box = yes
-| HGNCid = 6413
-| Symbol = KRT10
+| update_summary = no
-| AltSymbols = KPP
+| update_citations = yes
-| EntrezGene = 3858
-| OMIM = 148080
-| RefSeq = NM_000421
-| UniProt = P13645
-| PDB =
-| ECnumber =
-| Chromosome = 17
-| Arm = q
-| Band = 21
-| LocusSupplementaryData = -q23
 }}
-'''Keratin 10''' is a [[type I cytokeratin]]. Mutations in the gene encoding this protein are associated with the variants of [[epidermolytic hyperkeratosis]] in which the palms and [[sole]]s of the feet are unaffected.
+<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+{{GNF_Protein_box
+ | image =
+ | image_source =
+ | PDB =
+ | Name = Keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris)
+ | HGNCid = 6413
+ | Symbol = KRT10
+ | AltSymbols =; CK10; K10; KPP
+ | OMIM = 148080
+ | ECnumber =
+ | Homologene = 20125
+ | MGIid = 96685
+ | GeneAtlas_image1 = PBB_GE_KRT10_213287_s_at_tn.png
+ | GeneAtlas_image2 = PBB_GE_KRT10_207023_x_at_tn.png
+ | GeneAtlas_image3 = PBB_GE_KRT10_210633_x_at_tn.png
+ | Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0030280 |text = structural constituent of epidermis}}
+ | Component = {{GNF_GO|id=GO:0045095 |text = keratin filament}}
+ | Process = {{GNF_GO|id=GO:0008544 |text = epidermis development}}
+ | Orthologs = {{GNF_Ortholog_box
+    | Hs_EntrezGene = 3858
+    | Hs_Ensembl = ENSG00000186395
+    | Hs_RefseqProtein = NP_000412
+    | Hs_RefseqmRNA = NM_000421
+    | Hs_GenLoc_db =
+    | Hs_GenLoc_chr = 17
+    | Hs_GenLoc_start = 36227896
+    | Hs_GenLoc_end = 36232373
+    | Hs_Uniprot = P13645
+    | Mm_EntrezGene = 16661
+    | Mm_Ensembl = ENSMUSG00000019761
+    | Mm_RefseqmRNA = NM_010660
+    | Mm_RefseqProtein = NP_034790
+    | Mm_GenLoc_db =
+    | Mm_GenLoc_chr = 11
+    | Mm_GenLoc_start = 99201344
+    | Mm_GenLoc_end = 99205454
+    | Mm_Uniprot = P02535
+  }}
+}}
+'''Keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris)''', also known as '''KRT10''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KRT10 keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3858| accessdate = }}</ref>
+<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+{{PBB_Summary
+| section_title =
+| summary_text = This gene encodes a member of the type I (acidic) cytokeratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. Mutations in this gene are associated with [[epidermolytic hyperkeratosis]]. This gene is located within a cluster of keratin family members on chromosome 17q21.<ref name="entrez">{{cite web | title = Entrez Gene: KRT10 keratin 10 (epidermolytic hyperkeratosis; keratosis palmaris et plantaris)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3858| accessdate = }}</ref>
+}}
+==References==
+{{reflist}}
+==Further reading==
+{{refbegin | 2}}
+{{PBB_Further_reading
+| citations =
+*{{cite journal  | author=Yang JM, Nam K, Kim SW, ''et al.'' |title=Arginine in the beginning of the 1A rod domain of the keratin 10 gene is the hot spot for the mutation in epidermolytic hyperkeratosis. |journal=J. Dermatol. Sci. |volume=19 |issue= 2 |pages= 126-33 |year= 1999 |pmid= 10098704 |doi=  }}
+*{{cite journal  | author=Rasmussen HH, van Damme J, Puype M, ''et al.'' |title=Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes. |journal=Electrophoresis |volume=13 |issue= 12 |pages= 960-9 |year= 1993 |pmid= 1286667 |doi=  }}
+*{{cite journal  | author=Korge BP, Gan SQ, McBride OW, ''et al.'' |title=Extensive size polymorphism of the human keratin 10 chain resides in the C-terminal V2 subdomain due to variable numbers and sizes of glycine loops. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 3 |pages= 910-4 |year= 1992 |pmid= 1371013 |doi=  }}
+*{{cite journal  | author=Tkachenko AV, Buchman VL, Bliskovsky VV, ''et al.'' |title=Exons I and VII of the gene (Ker10) encoding human keratin 10 undergo structural rearrangements within repeats. |journal=Gene |volume=116 |issue= 2 |pages= 245-51 |year= 1992 |pmid= 1378806 |doi=  }}
+*{{cite journal  | author=Rothnagel JA, Dominey AM, Dempsey LD, ''et al.'' |title=Mutations in the rod domains of keratins 1 and 10 in epidermolytic hyperkeratosis. |journal=Science |volume=257 |issue= 5073 |pages= 1128-30 |year= 1992 |pmid= 1380725 |doi=  }}
+*{{cite journal  | author=Cheng J, Syder AJ, Yu QC, ''et al.'' |title=The genetic basis of epidermolytic hyperkeratosis: a disorder of differentiation-specific epidermal keratin genes. |journal=Cell |volume=70 |issue= 5 |pages= 811-9 |year= 1992 |pmid= 1381287 |doi=  }}
+*{{cite journal  | author=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317-20 |year= 1992 |pmid= 1602151 |doi=  }}
+*{{cite journal  | author=Nazzaro V, Ermacora E, Santucci B, Caputo R |title=Epidermolytic hyperkeratosis: generalized form in children from parents with systematized linear form. |journal=Br. J. Dermatol. |volume=122 |issue= 3 |pages= 417-22 |year= 1990 |pmid= 2182100 |doi=  }}
+*{{cite journal  | author=Darmon MY, Sémat A, Darmon MC, Vasseur M |title=Sequence of a cDNA encoding human keratin No 10 selected according to structural homologies of keratins and their tissue-specific expression. |journal=Mol. Biol. Rep. |volume=12 |issue= 4 |pages= 277-83 |year= 1988 |pmid= 2448602 |doi=  }}
+*{{cite journal  | author=Zhou XM, Idler WW, Steven AC, ''et al.'' |title=The complete sequence of the human intermediate filament chain keratin 10. Subdomainal divisions and model for folding of end domain sequences. |journal=J. Biol. Chem. |volume=263 |issue= 30 |pages= 15584-9 |year= 1988 |pmid= 2459124 |doi=  }}
+*{{cite journal  | author=Lessin SR, Huebner K, Isobe M, ''et al.'' |title=Chromosomal mapping of human keratin genes: evidence of non-linkage. |journal=J. Invest. Dermatol. |volume=91 |issue= 6 |pages= 572-8 |year= 1989 |pmid= 2461420 |doi=  }}
+*{{cite journal  | author=Rieger M, Franke WW |title=Identification of an orthologous mammalian cytokeratin gene. High degree of intron sequence conservation during evolution of human cytokeratin 10. |journal=J. Mol. Biol. |volume=204 |issue= 4 |pages= 841-56 |year= 1989 |pmid= 2464696 |doi=  }}
+*{{cite journal  | author=van Dongen GA, Braakhuis BJ, Leyva A, ''et al.'' |title=Anti-tumor and differentiation-inducing activity of N,N-dimethylformamide (DMF) in head-and-neck cancer xenografts. |journal=Int. J. Cancer |volume=43 |issue= 2 |pages= 285-92 |year= 1989 |pmid= 2465278 |doi=  }}
+*{{cite journal  | author=Rogaev EI, Rogaeva EA, Ginter EK, ''et al.'' |title=Identification of the genetic locus for keratosis palmaris et plantaris on chromosome 17 near the RARA and keratin type I genes. |journal=Nat. Genet. |volume=5 |issue= 2 |pages= 158-62 |year= 1994 |pmid= 7504553 |doi= 10.1038/ng1093-158 }}
+*{{cite journal  | author=Rothnagel JA, Longley MA, Holder RA, ''et al.'' |title=Prenatal diagnosis of epidermolytic hyperkeratosis by direct gene sequencing. |journal=J. Invest. Dermatol. |volume=102 |issue= 1 |pages= 13-6 |year= 1994 |pmid= 7507150 |doi=  }}
+*{{cite journal  | author=McLean WH, Eady RA, Dopping-Hepenstal PJ, ''et al.'' |title=Mutations in the rod 1A domain of keratins 1 and 10 in bullous congenital ichthyosiform erythroderma (BCIE). |journal=J. Invest. Dermatol. |volume=102 |issue= 1 |pages= 24-30 |year= 1994 |pmid= 7507152 |doi=  }}
+*{{cite journal  | author=Chipev CC, Yang JM, DiGiovanna JJ, ''et al.'' |title=Preferential sites in keratin 10 that are mutated in epidermolytic hyperkeratosis. |journal=Am. J. Hum. Genet. |volume=54 |issue= 2 |pages= 179-90 |year= 1994 |pmid= 7508181 |doi=  }}
+*{{cite journal  | author=Rothnagel JA, Fisher MP, Axtell SM, ''et al.'' |title=A mutational hot spot in keratin 10 (KRT 10) in patients with epidermolytic hyperkeratosis. |journal=Hum. Mol. Genet. |volume=2 |issue= 12 |pages= 2147-50 |year= 1994 |pmid= 7509230 |doi=  }}
+*{{cite journal  | author=Syder AJ, Yu QC, Paller AS, ''et al.'' |title=Genetic mutations in the K1 and K10 genes of patients with epidermolytic hyperkeratosis. Correlation between location and disease severity. |journal=J. Clin. Invest. |volume=93 |issue= 4 |pages= 1533-42 |year= 1994 |pmid= 7512983 |doi=  }}
+*{{cite journal  | author=Huber M, Scaletta C, Benathan M, ''et al.'' |title=Abnormal keratin 1 and 10 cytoskeleton in cultured keratinocytes from epidermolytic hyperkeratosis caused by keratin 10 mutations. |journal=J. Invest. Dermatol. |volume=102 |issue= 5 |pages= 691-4 |year= 1994 |pmid= 7513736 |doi=  }}
+}}
+{{refend}}
 {{protein-stub}}