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(+)-Menthofuran synthase

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(+)-Menthofuran synthase
Menthofuran synthase reaction
Identifiers
EC no.1.14.13.104
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BRENDABRENDA entry
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(+)-Menthofuran synthase (EC 1.14.13.104, menthofuran synthase, (+)-pulegone 9-hydroxylase, (+)-MFS, cytochrome P450 menthofuran synthase) is an enzyme with systematic name (+)-pulegone,NADPH:oxygen oxidoreductase (9-hydroxylating).[1][2] This enzyme catalyses the following chemical reaction

(+)-pulegone + NADPH + H+ + O2 (+)-menthofuran + NADP+ + H2O

Menthofuran synthase is a heme-thiolate protein (P-450).

References

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  1. ^ Bertea CM, Schalk M, Karp F, Maffei M, Croteau R (June 2001). "Demonstration that menthofuran synthase of mint (Mentha) is a cytochrome P450 monooxygenase: cloning, functional expression, and characterization of the responsible gene". Archives of Biochemistry and Biophysics. 390 (2): 279–86. doi:10.1006/abbi.2001.2378. PMID 11396930.
  2. ^ Mahmoud SS, Croteau RB (November 2003). "Menthofuran regulates essential oil biosynthesis in peppermint by controlling a downstream monoterpene reductase". Proceedings of the National Academy of Sciences of the United States of America. 100 (24): 14481–6. Bibcode:2003PNAS..10014481M. doi:10.1073/pnas.2436325100. PMC 283617. PMID 14623962.
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