The 2010–11 Eredivisie is the fifty-fifth season of Eredivisie since its establishment in 1955. It began on 6 August 2010 with the first matches of the season and ended on 29 May 2011 with the last matches of the European competition and relegation playoffs. FC Twente were the reigning champions, having won their first Dutch championship the previous season. A total of 18 teams took part in the league. Ajax won their 30th title after beating FC Twente 3–1 on 15 May 2011.
Sparta Rotterdam were also relegated at the end of the promotion/relegation playoff tournament, as they lost their two-legged play-off against city rivals SBV Excelsior on away goals. Sparta hence completed a 5-year stint in the league, while Excelsior played for the first time at the top level in 2 years. In contrast, Willem II retained their Eredivisie spot after beating Go Ahead Eagles after extra time of the return leg.
Rules for classification: 1) points; 2) goal difference; 3) number of goals scored. 1Since both 2010–11 KNVB Cup finalists, Twente and Ajax, qualified for the Champions League, allocation of the 2011–12 UEFA Europa League spots was based upon the final league standings, with the cup-winners spot going to the third-placed team and the regular spots available through league placement awarded to the next best teams below. 2NAC Breda were deducted 1 point because they were late with payment obligations to Contractspelers Fonds KNVB (CFK). (C) = Champion; (R) = Relegated; (P) = Promoted; (E) = Eliminated; (O) = Play-off winner; (A) = Advances to a further round.