|1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal
crystal structure of dxr in complex with the substrate 1-deoxy-d-xylulose-5-phosphate
DXP reductoisomerase or (1-deoxy-d-xylulose 5-phosphate reductoisomerase) is an enzyme that intraconverts 1-deoxy-D-xylulose 5-phosphate and 2-C-methyl-D-erythritol 4-phosphate.
It is classified under EC 188.8.131.527.
It is part of the non-mevalonate pathway, and it is inhibited by fosmidomycin.
It is normally abbreviated DXR, but it is sometimes named IspC.
This enzyme is responsible for terpenoid biosynthesis in some organisms. In Arabidopsis thaliana 1-deoxy-D-xylulose 5-phosphate reductoisomerase is the first committed enzyme of the non-mevalonate pathway for isoprenoid biosynthesis. The enzyme requires Mn2+, Co2+ or Mg2+ for activity, with Mn2+ being most effective.
This article incorporates text from the public domain Pfam and InterPro IPR013512
This article incorporates text from the public domain Pfam and InterPro IPR013644