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Aldo-keto reductase family 1, member C3
Protein AKR1C3 PDB 1ry0.png
PDB rendering based on 1ry0.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols AKR1C3 ; DD3; DDX; HA1753; HAKRB; HAKRe; HSD17B5; PGFS; hluPGFS
External IDs OMIM603966 MGI2145420 HomoloGene128661 ChEMBL: 4681 GeneCards: AKR1C3 Gene
EC number,,,,,
RNA expression pattern
PBB GE AKR1C3 209160 at tn.png
PBB GE AKR1C1 211653 x at tn.png
More reference expression data
Species Human Mouse
Entrez 8644 105349
Ensembl ENSG00000196139 ENSMUSG00000021214
UniProt P42330 Q8K023
RefSeq (mRNA) NM_001253908 NM_134066
RefSeq (protein) NP_001240837 NP_598827
Location (UCSC) Chr 10:
5.08 – 5.15 Mb
Chr 13:
4.13 – 4.15 Mb
PubMed search [1] [2]

Aldo-keto reductase family 1 member C3 is a key steroidogenic enzyme that in humans is encoded by the AKR1C3 gene.[1][2][3]

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.[3]



  1. ^ Khanna M, Qin KN, Wang RW, Cheng KC (Sep 1995). "Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases". J Biol Chem 270 (34): 20162–8. doi:10.1074/jbc.270.34.20162. PMID 7650035. 
  2. ^ Matsuura K, Shiraishi H, Hara A, Sato K, Deyashiki Y, Ninomiya M, Sakai S (Feb 1999). "Identification of a principal mRNA species for human 3alpha-hydroxysteroid dehydrogenase isoform (AKR1C3) that exhibits high prostaglandin D2 11-ketoreductase activity". J Biochem 124 (5): 940–6. doi:10.1093/oxfordjournals.jbchem.a022211. PMID 9792917. 
  3. ^ a b "Entrez Gene: AKR1C3 aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)". 
  4. ^ Tian, Y; Zhao, L; Zhang, H; Liu, X; Zhao, L; Zhao, X; Li, Y; Li, J (2014). "AKR1C3 overexpression may serve as a promising biomarker for prostate cancer progression". Diagnostic Pathology 9 (1): 42. doi:10.1186/1746-1596-9-42. PMC 3939640. PMID 24571686.  edit

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