The game features characters Stitch from Lilo & Stitch, Dory from Finding Nemo, Winnie the Pooh, and Simba from The Lion King. Disney Friends uses voice and touch to control the actions and emotional behaviors of the game’s characters; it features adventure elements which offers players the opportunity to bond with the characters, while exploring memorable film environments and moments. The game also includes collecting Disney pins if the player does certain tasks, like raising a friendship level. For example, on special days like the user's birthday, the characters may do something special for them, like wear a hat and say "Happy Birthday!"
The game takes place in Cinderella's Castle. In order to unlock Stitch, the player must do Guardian Training with the Alien from Toy Story. When the user unlocks Stitch, more Guardian Training must be followed. Stitch will give the user a camera which results in a daily photo opportunity with Stitch.
To unlock Dory, the player must be a rookie. To unlock Pooh, the player must be an assistant. To unlock Simba, the player much be a novice.