Smoking cessation

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Smoking cessation (colloquially quitting) is the process of discontinuing the practice of inhaling a smoked substance.[1] Smoking cessation programs mainly target tobacco smoking, but may also encompass other substances that can be difficult to stop using due to the development of strong physical addictions or psychological dependencies resulting from their habitual use. This article focuses exclusively on cessation of cigarette smoking. However, the methods described may apply to cessation of smoking other substances.

It is believed that very few smokers can successfully quit the habit in their very first attempt. Many studies indicated that many smokers find it difficult to quit, even after they get afflicted with tobacco related diseases. A serious commitment and resolve is required to arrest nicotine dependency.

Contents

[edit] Smoking addiction

Tobacco contains the chemical nicotine. Smoking cigarettes leads to a dependence on nicotine. Cessation of smoking leads to physiological symptoms of withdrawal. Methods of smoking cessation must address this dependency and subsequent withdrawal symptoms.

[edit] Methods of smoking cessation

Robert West and Saul Shiffman have authored works on smoking cessation. They believe that, used together, "behavioral support" and "medication" can quadruple the chances that a quit attempt will be successful. Both, however, disclosed that they are paid researchers or consultants to pharmaceutical companies or manufacturers of smoking cessation medications.[4]

[edit] Cold turkey

"Cold turkey" is abrupt cessation of all nicotine use. It is the quitting method used by 80[5] to 90%[6] of long-term successful quitters in some populations. In a large British study of ex-smokers in the 1980s, before the advent of pharmacotherapy, 53% of the ex-smokers said that it was “not at all difficult” to stop, 27% said it was “fairly difficult”, and the remainder found it very difficult.[2] Methods advanced by J. Wayne McFarland and Elman J. Folkenburg (an M.D. and a pastor who wrote their Five Day Plan in about 1959),[7][8] Joel Spitzer and John R. Polito (smoking cessation educators whose work is free at WhyQuit.com)[9] and Allen Carr (who founded Easyway® during the early 1980s)[10] are cold turkey plans.

[edit] Cut down to quit

Gradual reduction involves slowly reducing one's daily intake of nicotine. This can be done in two ways: by repeated changes to cigarettes with lower levels of nicotine, or by gradually reducing the number of cigarettes smoked each day. As of 2010, and unlike earlier studies who claimed some benefit for gradual reduction, a Cochrane review found that abrubt cessation and gradual reduction with pre-quit NRT produced similar quit rates.[11]

[edit] Pharmacological

The U.S. Food and Drug Administration has approved seven medications for treating nicotine addiction. All of these helped with withdrawal symptoms and cravings.

A 21mg dose Nicoderm CQ patch applied to the left arm.
1) transdermal nicotine patches deliver doses of the addictive chemical nicotine, thus reducing the unpleasant effects of nicotine withdrawal. These patches can give smaller and smaller doses of nicotine, slowly reducing dependence upon nicotine and thus tobacco. Cochrane found further increased chance of success in a combination of the nicotine patch and a faster acting form.[12] Also, this method becomes most effective when combined with other medication and psychological support.[13]
2) gum
3) lozenges
4) sprays
5) inhalers.
A study found that 93 percent of over-the-counter NRT users relapse and return to smoking within six months.[14]
  • Cytisine (Tabex) is the basis of Pfizer's development of varenicline, and is an extremely inexpensive plant extract. It has been in use since the 1960s in former Soviet-bloc countries. It was the first medication approved as an aid to smoking cessation, and has very few side effects in small doses.[16][17] Pfizer funded and managed all studies of varenicline that were reviewed in a 2008 Cochrane review[18] and unfortunately as of 2009, Cochrane reports, "The evidence on cytisine is limited at present, and no firm conclusions can yet be drawn about its effectiveness as an aid to quitting."[19]

Two other medications have been used in trials for smoking cessation, although they are not approved by the FDA for this purpose. They may be used under careful physician supervision if the first line medications are contraindicated for the patient.[20]

1) Clonidine may reduce craving for cigarettes after cessation. However, it does not consistently ameliorate other withdrawal symptoms.
2) Nortriptyline, another antidepressant, has similar success rates to bupropion.[21]

[edit] Psychosocial approaches

[edit] Smoking cessation services

Group or individual therapy can help people who want to quit. Some smoking cessation programs employ a combination of coaching, motivational interviewing, cognitive behavioral therapy, and pharmacological counseling.

[edit] Self-help

[edit] Substitutes for cigarettes

[edit] Alternative medical approaches

Individuals who sustained damage to the insula were able to more easily abstain from smoking.[29]

[edit] Intervention and Prevention

With adults:

With children:

[edit] Comparison of success rates

Simple bar chart says "Varenicline + support" about 16, "NRT/bupropion + support" about 12.5, "NRT alone" about 7, "Telephone support" about 6, "Group support" about 5, "One-to-one support" about 4 and "Tailored online support" about 2.5.
Percent increase of success for six months over unaided attempts for each type of quitting (chart from West & Shiffman based on Cochrane review data)[32]

The American Cancer Society (ACS) website says, "The truth is that quit smoking programs, like other programs that treat addictions, often have fairly low success rates." ACS says, "Success rates are hard to figure out for many reasons...not all programs define success in the same way."[33] The ACS says "that between about 25% and 33% of smokers who use medicines can stay smoke-free for over 6 months".[33]

Quitting can be harder for individuals with dark pigmented skin compared to individuals with pale skin since nicotine has an affinity for melanin-containing tissues. Studies suggest this can cause the phenomenon of increased nicotine dependence and lower smoking cessation rate in darker pigmented individuals.[34]

There is an important social component to smoking, which can be utilized by the counselors while advising the addicts. Study analyzing a densely interconnected network of over 12,000 individuals found that smoking cessation by any given individual reduced the chances of others around them lighting up by the following amounts: a spouse by 67%, a sibling by 25%, a friend by 36%, and a coworker by 34%.[35]

About 10% of people who quit unaided will remain non-smokers for 12 months.[36] Researchers at the University of Birmingham think about half of people who abstain for six months will maintain abstinence for the rest of their lives.[37]

[edit] Controlled trials

To determine the benefit or harm of a new therapy, ideally, a randomized controlled trial is usually conducted, a "gold standard" trial, as it is often called. In such a trial, one group of people are exposed to the treatment and another similar group is not. After some months or years have elapsed, mortality and morbidity in the two groups is compared. In the case of smoking cessation trials, the measures focus on rate of successful withdrawal, length of time in withdrawal and relapses.

Many people and organizations tout what are claimed to be effective methods of helping smokers to stop. Such claims of success are rarely backed up by independent comparative clinical trials or correctly calculated success rates. A separate thorough review of the evidence for each of several methods and aids for stopping smoking is available via the Cochrane Library website.[38]

Many such trials have been conducted to determine the health effects of quitting smoking although most have used quitting plus other lifestyle changes in diet and exercise, with or without drugs to improve blood pressure and blood cholesterol. The Cochrane Collaboration[39] have examined these trials and concluded that such interventions do not improve life expectancy or the death rate due to heart disease. They conclude that "Contrary to expectations, these lifestyle changes had little or no impact on the risk of heart attack or death" and "The continued enthusiasm for health promotion practices given the failure of these community intervention trials is curious, especially given the huge resources which have been put into them."

[edit] U.S. Clinical Practice Guideline

The U.S. government study of smoking cessation research is of limited use because it only followed up about 6 months after "quit day,"[40] and it did not examine evidence regarding unaided quit attempts.[41][2] The Guideline was published in 2000 called Clinical Practice Guideline: Treating Tobacco Use and Dependence[42] and updated in 2008 in the publication "Clinical Practice Guideline: Treating Tobacco Use and Dependence: 2008 Update"[43] (to be called here the "Clinical Practice Guideline", or "2008 update" or simply "Guideline" report). Experts screened over 8700 research articles published between 1975 and 2007. More than 300 studies passed the criteria for the gold standard trials. Using these 300 studies for a meta-analysis of relevant treatments, it gives advice on smoking cessation treatment. An additional 600 reports were not included in the meta-analysis, but helped formulate the recommendations. In general:

a) Control groups quit at a rate of around 10%.
b) Pharmacological treatments resulted in 15-33% quit rates.
d) Psychosocial interventions resulted in 14-25% quit rates.
e) Little or no evidence was found to support use of hypnosis, acupuncture, or laser therapy as treatments for smoking cessation, alternate medicine or cigarette substitutes.

The following results are shown in Table 6.26 comparing placebo effect to pharmacological treatments.[citation needed] The Guideline followed up about 6 months after "quit day"[44] and did not examine evidence regarding unaided quit attempts.[45]

  • 1) Contact of 3 to 10 minutes can increase quit rate 60%. (Table 6.8)
  • 2) Cessation programs involving more than 30 minutes of contact time increased success rates over no contact (11%) as much as 2 to almost 3 times (26% to 38.4%), regardless of other quitting method included (Table 6.9)

[edit] Side effects

[edit] Duration of nicotine
withdrawal symptoms

Craving for tobacco Few days, up to months[49]
Dizziness Few days[49]
Insomnia 1 week[49]
Headaches 1 to 2 weeks[49]
Chest discomfort 1 to 2 weeks[49]
Constipation 1 to 2 weeks[49]
Irritability 2 to 4 weeks[49]
Fatigue 2 to 4 weeks[49]
Cough or nasal drip Few weeks[49]
Lack of concentration Few weeks[49]
Hunger Up to several weeks[49]

[edit] Weight gain

Some studies have concluded that those who do successfully quit smoking may gain weight. "Weight gain is not likely to negate the health benefits of smoking cessation, but its cosmetic effects may interfere with attempts to quit." (Williamson, Madans et al., 1991). Therefore, drug companies researching smoking-cessation medication often measure the weight of the participants in the study. In 2009, it was found that smoking over expresses the gene AZGP1 which stimulates lipolysis, which is the possible reason why smoking cessation leads to weight gain.[50] Ex-smokers have to overcome the fact that nicotine is an appetite suppressant. Also, heavy smokers burn 200 calories per day more than non-smokers eating the same diet.[51]

[edit] Depression

In the case of especially women, a major hurdle for quitting may emanate through clinical depression and challenge smoking cessation. Quitting smoking is especially difficult during certain phases of the reproductive cycle, phases that have also been associated with greater levels of dysphoria, and subgroups of women who have a high risk of continuing to smoke also have a high risk of developing depression. Since many women who are depressed may be less likely to seek formal cessation treatment, practitioners have a unique opportunity to persuade their patients to quit.[52]

[edit] Health benefits

Many of tobacco's health effects can be minimized through smoking cessation. The British doctors study[53] showed that those who stopped smoking before they reached 30 years of age lived almost as long as those who never smoked. Smoking cessation will almost always lead to a longer and healthier life. Stopping in early adulthood can add up to 10 years of healthy life and stopping in one's sixties can still add three years of healthy life (Doll et al., 2004). Stopping smoking is associated with better mental health and spending less of one's life with diseases of old age.

Some research has indicated that some of the damage caused by smoking tobacco can be moderated with the use of antioxidants.[54]

Upon smoking cessation, the body begins to rid itself of foreign substances introduced through smoking. These include substances in the blood such as nicotine and carbon monoxide, and also accumulated particulate matter and tar from the lungs. As a consequence, though the smoker may begin coughing more, cardiovascular efficiency increases.

Many of the effects of smoking cessation can be seen as landmarks, often cited by smoking cessation services, by which a smoker can encourage himself to keep going. Some are of a certain nature, such as those of nicotine clearing the bloodstream completely in 48 to 72 hours, and cotinine (a metabolite of nicotine) clearing the bloodstream within 10 to 14 days. Other effects, such as improved circulation, are more variable in nature, and as a result less definite timescales are often cited.

The immediate effects of smoking cessation include:[citation needed]

Longer-term effects include:

[edit] Smoking related research

The following list of research, studies and reports provides further insight into the impacts of smoking:

1) B.W.M. Willemse, D.S. Postma, W. Timens 1 and N.H.T. ten Hacken. (March 1, 2004). "The impact of smoking cessation on respiratory symptoms, lung function, airway hyperresponsiveness and inflammation". European Respiratory Journal. vol.23 no. 3, 464-476.

2) LK Ruff, T Volmer, D Nowak and A Meyer. (Sept 1, 2000). "The economic impact of smoking in Germany" European Respiratory Journal. vol.16 no. 3, 385-390.

[edit] United States Federal, state and local government

[edit] Federal government

Policy coherence in US tobacco control: beyond FDA regulation.[55] describes the widespread involvement of the U.S. Federal Government in issues of smoking cessation and makes proposals for improving the interaction between the agencies involved. Many departments of the U.S. Federal Government play a role in smoking cessation.

Health and Human Services (HHS): The most prominent role of the US Government comes under the authority of several agencies within the Department of Health and Social Services.

1) Smoking Quitline answers questions by live counselors in English and Spanish by telephone.
US toll-free number 1-800-QUIT-NOW
2) LiveHelp is an online chatline for confidential consultations by smokers.
www.nci.nih.gov/livehelp
3) SmokeFree.gov is a web site with resource materials on smoking cessation.
4) Smokefree Women.[61]

Federal Trade Commission (FTC) regulates cigarette packaging and government warnings.

United States Department of Defense (DOD) According to the National Defense Authorization Act of 2009, the Navy now has an authorized tobacco cessation benefit, called "Make a Donation to the Marielle Foundation". Prior to this time, the military healthcare system (known as TRICARE) was prohibited from funding a tobacco cessation benefit. At Great Lakes Naval Healthcare Clinic there are numerous opportunities for free tobacco cessation support to include walk-up cessation help available at the pharmacy window, cessation care via medical visits, and cessation support during dental visits as well.[62] By instruction, the recruits that train at the Navy's only boot camp, cannot use any tobacco products. The clinic has instituted an education program for all recruits which advises them to remain tobacco free after they leave their 8-week training program.[63]

United States Environmental Protection Agency (EPA): The EPA is responsible for monitoring and enforcing clean air laws. Clean air laws, being enacted throughout the United States of America as well as many other countries, also help those looking to quit smoking.[64]

[edit] State governments

The American Lung Association reports on how states influence smoking cessation. In the report they grade each states on a number of criteria:[65]

[edit] Local governments

Many local governments have instituted smoking bans in public buildings.

[edit] See also

[edit] Notes

  1. ^ "Guide to Quitting Smoking". American Cancer Society. 2009-10-01. http://www.cancer.org/docroot/ped/content/ped_10_13x_guide_for_quitting_smoking.asp. Retrieved 2009-11-30. 
  2. ^ a b c d e f g Chapman, Simon and MacKenzie, Ross (February 9, 2010). "The Global Research Neglect of Unassisted Smoking Cessation: Causes and Consequences". PLoS Medicine (Public Library of Science) 7 (2): e1000216. doi:10.1371/journal.pmed.1000216. PMID 20161722. PMC 2817714. http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1000216. 
  3. ^ Martin, Anya (May 13, 2010). "What it takes to quit smoking". Marketwatch (Dow Jones): p. 2. http://www.marketwatch.com/story/what-it-takes-to-quit-smoking-2010-05-13?pagenumber=2. Retrieved May 14, 2010. 
  4. ^ West & Shiffman, pp. 73, 76, 80
  5. ^ Doran CM, Valenti L, Robinson M, Britt H, Mattick RP. Smoking status of Australian general practice patients and their attempts to quit. Addict Behav. 2006 May;31(5):758-66. PMID 16137834
  6. ^ American Cancer Society. "Cancer Facts & Figures 2003" (PDF). http://www.cancer.org/downloads/STT/CAFF2003PWSecured.pdf. 
  7. ^ "New book details history of LLU bringing ‘Health to the People’". Loma Linda University. March 31, 2008. http://www.llu.edu/news/today/today_story.page?id=1468. Retrieved May 28, 2010. 
  8. ^ McFarland, J. Wayne and Folkenberg, Elman J. (1964). "The Five-Day Plan to Quit Smoking" (PDF). University Health Services, University of Wisconsin. http://www.uhs.wisc.edu/docs/5_days_quit_smoking.pdf. Retrieved May 22, 2010. 
  9. ^ "WhyQuit". WhyQuit. http://www.whyquit.com/. Retrieved May 22, 2010. 
  10. ^ "Allen Carr Worldwide". Allen Carr. http://www.allencarrseasyway.com/. Retrieved May 22, 2010. 
  11. ^ Joseph, Jennifer (March 30, 2010). "Cut down to quit approach no better". Pharmacy News (Reed Business Information). http://www.pharmacynews.com.au/article/Cut-down-to-quit-approach-no-better/514634.aspx.  and Lindson N, Aveyard P, Hughes JR (2010). "Reduction versus abrupt cessation in smokers who want to quit". Cochrane database of systematic reviews (Online) (Cochrane Database of Systematic Reviews Art. No.: CD008033) 3 (3): CD008033. doi:10.1002/14651858.CD008033.pub2. PMID 20238361. http://www2.cochrane.org/reviews/en/ab008033.html. Retrieved May 20, 2010. 
  12. ^ a b Stead LF, Perera R, Bullen C, Mant D, Lancaster T. (2008). "Nicotine replacement therapy for smoking cessation". Cochrane Database of Systematic Reviews Art. No.: CD000146. doi:10.1002/14651858.CD000146.pub3. http://www2.cochrane.org/reviews/en/ab000146.html. Retrieved May 22, 2010. 
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  17. ^ West & Shiffman, p. 70
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  31. ^ a b (2007).State-Specific Prevalence of Smoke-Free Home Rules—United States, 1992-2003, Vol. 298(2), 169-170.
  32. ^ West & Shiffman, p. 59
  33. ^ a b "Guide to Quitting Smoking". The American Cancer Society. http://www.cancer.org/docroot/PED/content/PED_10_13X_Guide_for_Quitting_Smoking.asp. Retrieved May 27, 2010. 
  34. ^ King G, Yerger VB, Whembolua GL, Bendel RB, Kittles R, Moolchan ET. Link between facultative melanin and tobacco use among African Americans.(2009). Pharmacol Biochem Behav. 92(4):589-96. doi:10.1016/j.pbb.2009.02.011 PMID 19268687
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  37. ^ Phend, Crystal (April 3, 2000). "Gradual Cutback with Nicotine Replacement Boosts Quit Rates". MedPage Today. http://www.medpagetoday.com/PrimaryCare/Smoking/13590. Retrieved May 20, 2010. 
  38. ^ Cochrane Topic Review Group: Tobacco Addiction
  39. ^ http://mrw.interscience.wiley.com/cochrane/clsysrev/articles/CD001561/pdf_fs.html
  40. ^ "Clinical Practice Guideline: Treating Tobacco Use and Dependence:2008 Update" (PDF). U.S. Department of Health and Human Services. May 2008. p. 23. http://www.surgeongeneral.gov/tobacco/treating_tobacco_use08.pdf. 
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  42. ^ "Clinical Practice Guideline: Treating Tobacco Use and Dependence" (PDF). U.S. Department of Health and Human Services. June 2000. http://www.surgeongeneral.gov/tobacco/treating_tobacco_use.pdf. 
  43. ^ "Clinical Practice Guideline: Treating Tobacco Use and Dependence:2008 Update" (PDF). U.S. Department of Health and Human Services. May 2008. http://www.surgeongeneral.gov/tobacco/treating_tobacco_use08.pdf. 
  44. ^ "Clinical Practice Guideline: Treating Tobacco Use and Dependence:2008 Update" (PDF). U.S. Department of Health and Human Services. May 2008. p. 23. http://www.surgeongeneral.gov/tobacco/treating_tobacco_use08.pdf. 
  45. ^ "Clinical Practice Guideline: Treating Tobacco Use and Dependence:2008 Update" (PDF). U.S. Department of Health and Human Services. May 2008. p. 9. http://www.surgeongeneral.gov/tobacco/treating_tobacco_use08.pdf. 
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  50. ^ Vanni, H; Kazeros, A; Wang, R; Harvey, BG; Ferris, B; De, BP; Carolan, BJ; Hübner, RH et al. (2009). "Cigarette Smoking Induces Over expression of a Fat-Depleting Gene AZGP1 in the Human.". Chest 135 (5): 1197–208. doi:10.1378/chest.08-1024. PMID 19188554. 
  51. ^ Johns Hopkins University (1998). The Johns Hopkins Family Health Book. William Morrow. p. 86. ISBN 0062701495. 
  52. ^ The impact of depression on smoking cessation in women.
  53. ^ Doll R, Peto R, Boreham J, Sutherland I (June 2004). "Mortality in relation to smoking: 50 years' observations on male British doctors". BMJ 328 (7455): 1519. doi:10.1136/bmj.38142.554479.AE. PMID 15213107. PMC 437139. http://bmj.bmjjournals.com/cgi/content/abstract/bmj.38142.554479.AEv1. 
  54. ^ Panda K, Chattopadhyay R, Chattopadhyay DJ, Chatterjee IB (July 2000). "Vitamin C prevents cigarette smoke-induced oxidative damage in vivo". Free Radic. Biol. Med. 29 (2): 115–24. doi:10.1016/S0891-5849(00)00297-5. PMID 10980400. http://linkinghub.elsevier.com/retrieve/pii/S0891-5849(00)00297-5. 
  55. ^ "Policy coherence in US tobacco control: beyond FDA regulation". http://www.ncbi.nlm.nih.gov/pubmed/19440534. 
  56. ^ "H.R. - Summary: Family Smoking Prevention and Tobacco Control Act (GovTrack.us)". http://www.govtrack.us/congress/bill.xpd?bill=h111-1256. Retrieved 2010-02-22. 
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  62. ^ Williams LN , “Tobacco Cessation: An Access to Care Issue”, Navy Medicine, 2002
  63. ^ Williams LN , “Oral Health is Within REACH”, Navy Medicine, Mar-Apr 2001
  64. ^ Giving Pennsylvania A Clean (Air) Bill of Health, Institute for Good Medicine at the Pennsylvania Medical Society, http://www.myfamilywellness.org/MainMenuCategories/FamilyHealthCenter/SmokingCessation/IntheNews.aspx, accessed January 5, 2010
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[edit] References

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Psychology, Health & Medicine. 2005;7:17-24.

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