The tour saw the band headlining several stadiums and festivals throughout Europe, with the concert at Ullevi Stadium in Gothenburg, Sweden on 9 July being broadcast live in full on both Swedish national television and radio, and co-headlining with Black Sabbath for the majority of the North American Ozzfest tour.
The final date of the US segment of the tour (Hyundai Pavilion in San Bernardino, CA on 20 August 2005) ended on a sour note. Throughout the tour, vocalist Bruce Dickinson reportedly made several comments about reality television, the widespread use of autocue by current bands and the fact that Iron Maiden had headlined several dates of the tour (due to Ozzy Osbourne's illness), to which Osbourne's wife, Sharon, took offence. In retaliation, they placed family friends in the crowd to sabotage Iron Maiden's performance by throwing eggs, bottle tops and lighters from the front of the audience. In addition, the P.A. system was shut off multiple times, cutting off power to Dickinson's microphone and the band's instruments mid-song and members of other bands were recruited to cause further disturbance, such as by running on-stage with an American flag during "The Trooper". The effort to ruin the band's show seemed to have been in vain, however, as the band reportedly played even better as their performance was disrupted. Shortly after Iron Maiden's set, Sharon entered the stage to the unanimous boos from the crowd and stated that, while she loves Iron Maiden, Dickinson is a "prick."
Following the show, Iron Maiden's manager Rod Smallwood issued a statement condemning the incident.
At a small number of shows, an inflatable Eddie (identical to that of the first album cover) would appear during "Iron Maiden". However, for the majority of the tour, the giant Eddie from the Give Me Ed... 'Til I'm Dead Tour was used in its place. The walk-on Eddie would also appear during "Drifter", either in a straight-jacket (as on "Piece of Mind") or as a replica of the original used on "The Beast on the Road" tour.
Unlike in the album, the soft beginning of "Murders in the Rue Morgue" (from Killers, 1981) was skipped and started off at the drum beat.
"Charlotte The Harlot" (from Iron Maiden, 1980) was replaced by "Wrathchild" (from Killers, 1981) after the first two gigs.
On the American leg, the band's setlist was typically reduced to just 10 songs, although this number was increased at selected shows. When Osbourne was too ill to perform, the band would play their full setlist, headlining in Black Sabbath's place.