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Fc fragment of IgG, receptor, transporter, alpha
Protein FCGRT PDB 1exu.png
PDB rendering based on 1exu.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols FCGRT ; FCRN; alpha-chain
External IDs OMIM601437 MGI103017 HomoloGene3030 ChEMBL: 5966 GeneCards: FCGRT Gene
RNA expression pattern
PBB GE FCGRT 218831 s at tn.png
More reference expression data
Species Human Mouse
Entrez 2217 14132
Ensembl ENSG00000104870 ENSMUSG00000003420
UniProt P55899 Q61559
RefSeq (mRNA) NM_001136019 NM_010189
RefSeq (protein) NP_001129491 NP_034319
Location (UCSC) Chr 19:
50.01 – 50.03 Mb
Chr 7:
45.09 – 45.1 Mb
PubMed search [1] [2]

IgG receptor FcRn large subunit p51 is a protein that in humans is encoded by the FCGRT gene.[1][2][3]


FCGRT has been shown to interact with Human serum albumin.[4]


  1. ^ Story CM, Mikulska JE, Simister NE (December 1994). "A major histocompatibility complex class I-like Fc receptor cloned from human placenta: possible role in transfer of immunoglobulin G from mother to fetus". J Exp Med 180 (6): 2377–81. doi:10.1084/jem.180.6.2377. PMC 2191771. PMID 7964511. 
  2. ^ Kandil E, Egashira M, Miyoshi O, Niikawa N, Ishibashi T, Kasahara M (July 1996). "The human gene encoding the heavy chain of the major histocompatibility complex class I-like Fc receptor (FCGRT) maps to 19q13.3". Cytogenet Cell Genet 73 (1-2): 97–8. doi:10.1159/000134316. PMID 8646894. 
  3. ^ "Entrez Gene: FCGRT Fc fragment of IgG, receptor, transporter, alpha". 
  4. ^ Chaudhury, Chaity; Mehnaz Samina; Robinson John M; Hayton William L; Pearl Dennis K; Roopenian Derry C; Anderson Clark L (February 2003). "The major histocompatibility complex-related Fc receptor for IgG (FcRn) binds albumin and prolongs its lifespan". J. Exp. Med. (United States) 197 (3): 315–22. doi:10.1084/jem.20021829. ISSN 0022-1007. PMC 2193842. PMID 12566415. 

Further reading[edit]