CD64 (biology)

Fc fragment of IgG, high affinity Ic, receptor (CD64)
Identifiers
Symbol	FCGR1C
Entrez	2211
HUGO	3615
OMIM	601503
RefSeq	XM_001133198
Other data
Locus	Chr. 1 q21.1

Fc fragment of IgG, high affinity Ib, receptor (CD64)
Identifiers
Symbol	FCGR1B
Entrez	2210
HUGO	3614
OMIM	601502
RefSeq	NM_001004340
UniProt	Q92637
Other data
Locus	Chr. 1 p11.2

Fc fragment of IgG, high affinity Ia, receptor (CD64)
Identifiers
Symbol	FCGR1A
Entrez	2209
HUGO	3613
OMIM	146760
RefSeq	NM_000566
UniProt	P12314
Other data
Locus	Chr. 1 q21.2-21.3

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CD64 (Cluster of Differentiation 64) is a type of integral membrane glycoprotein known as an Fc receptor that binds monomeric IgG-type antibodies with high affinity.^[1] It is more commonly known as Fc-gamma receptor 1 (FcγRI). After binding IgG, CD64 interacts with an accessory chain known as the common γ chain (γ chain), which possesses an ITAM motif that is necessary for triggering cellular activation.^[2]

Structurally CD64 is composed of a signal peptide that allows its transport to the surface of a cell, three extracellular immunoglobulin domains of the C2-type that it uses to bind antibody, a hydrophobic transmembrane domain, and a short cytoplasmic tail.^[3]

CD64 is constitutively found on only macrophages and monocytes, but treatment of polymorphonuclear leukocytes with cytokines like IFNγ and G-CSF can induce CD64 expression on these cells.^[4]^[5]

There are three distinct (but highly similar) genes in humans for CD64 called FcγRIA (CD64A), FcγRIB (CD64B), and FcγRIC (CD64C) that are located on chromosome 1.^[6] These three genes produce six different mRNA transcripts ; two from CD64A, three from CD64B, and one from CD64C; by alternate splicing of the genes.^[3]

[edit] References

^ Hulett M, Hogarth P (1998). "The second and third extracellular domains of FcgammaRI (CD64) confer the unique high affinity binding of IgG2a". Mol Immunol 35 (14-15): 989–96. doi:10.1016/S0161-5890(98)00069-8. PMID 9881694.
^ Nimmerjahn F, Ravetch J (2006). "Fcgamma receptors: old friends and new family members". Immunity 24 (1): 19–28. doi:10.1016/j.immuni.2005.11.010. PMID 16413920.
^ ^a ^b Ernst L, Duchemin A, Miller K, Anderson C (1998). "Molecular characterization of six variant Fcgamma receptor class I (CD64) transcripts". Mol Immunol 35 (14-15): 943–54. PMID 9881690.
^ Perussia B, Dayton E, Lazarus R, Fanning V, Trinchieri G (1983). "Immune interferon induces the receptor for monomeric IgG1 on human monocytic and myeloid cells". J Exp Med 158 (4): 1092–113. doi:10.1084/jem.158.4.1092. PMC 2187379. PMID 6225822. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2187379.
^ Repp R, Valerius T, Sendler A, Gramatzki M, Iro H, Kalden J, Platzer E (1991). "Neutrophils express the high affinity receptor for IgG (Fc gamma RI, CD64) after in vivo application of recombinant human granulocyte colony-stimulating factor". Blood 78 (4): 885–9. PMID 1714327.
^ Ernst L, van de Winkel J, Chiu I, Anderson C (1992). "Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products". J Biol Chem 267 (22): 15692–700. PMID 1379234.

[edit] External links

MeSH CD64+Antigens

This immunology article is a stub. You can help Wikipedia by expanding it.

[0] Hulett M, Hogarth P (1998). "The second and third extracellular domains of FcgammaRI (CD64) confer the unique high affinity binding of IgG2a". Mol Immunol 35 (14-15): 989–96. doi:10.1016/S0161-5890(98)00069-8. PMID 9881694.

[1] Nimmerjahn F, Ravetch J (2006). "Fcgamma receptors: old friends and new family members". Immunity 24 (1): 19–28. doi:10.1016/j.immuni.2005.11.010. PMID 16413920.

[Ernst_L.2C_Duchemin_A.2C_Miller_K.2C_Anderson_C_1998_943.E2.80.9354-2] Ernst L, Duchemin A, Miller K, Anderson C (1998). "Molecular characterization of six variant Fcgamma receptor class I (CD64) transcripts". Mol Immunol 35 (14-15): 943–54. PMID 9881690.

[3] Perussia B, Dayton E, Lazarus R, Fanning V, Trinchieri G (1983). "Immune interferon induces the receptor for monomeric IgG1 on human monocytic and myeloid cells". J Exp Med 158 (4): 1092–113. doi:10.1084/jem.158.4.1092. PMC 2187379. PMID 6225822. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2187379.

[4] Repp R, Valerius T, Sendler A, Gramatzki M, Iro H, Kalden J, Platzer E (1991). "Neutrophils express the high affinity receptor for IgG (Fc gamma RI, CD64) after in vivo application of recombinant human granulocyte colony-stimulating factor". Blood 78 (4): 885–9. PMID 1714327.

[5] Ernst L, van de Winkel J, Chiu I, Anderson C (1992). "Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products". J Biol Chem 267 (22): 15692–700. PMID 1379234.

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CD64 (biology)

[edit] References

[edit] External links

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