CD16

Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

Identifiers
Symbol	FCGR3A
Alt. symbols	FCGR3, FCG3
Entrez	2214
HUGO	3619
OMIM	146740
RefSeq	NM_000569
UniProt	P08637
Other data
Locus	Chr. 1 q23

Fc fragment of IgG, low affinity IIIb, receptor (CD16b)

Identifiers
Symbol	FCGR3B
Alt. symbols	FCGR3, FCG3
Entrez	2215
HUGO	3620
OMIM	610665
RefSeq	NM_000570
UniProt	O75015
Other data
Locus	Chr. 1 q23

CD16 is a low affinity Fc receptor.

It is a cluster of differentiation found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages. It can be used to isolate populations of these cells by antibodies directed towards CD16, utilising FACS (fluorescent-activated cell sorting) or MACS (magnetic-activated cell sorting).

Function

CD16 has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies.

External links

• MeSH CD16+Antigens