The 1990-91 season saw Sampdoria win the Serie A title for the first time in their history, finishing five points ahead of second placed AC Milan. Third placed Inter Milan were victorious in the UEFA Cup, with ninth-placd AS Roma compensating for their sub-standard league season with glory in the Coppa Italia, while Juventus's seventh placed finish meant that they would be without European action for the first season in three decades. Lecce, Pisa, Cesena and Bologna were all relegated.
A notable record was set on 9 December 1990 in a Serie A fixture, when Bologna player Giuseppe Lorenzo was sent off after just 10 seconds for striking an opponent in the match against Parma. This was reportedly the fastest sending off in senior football worldwide at the time.