Sorbitol-6-phosphate 2-dehydrogenase

sorbitol-6-phosphate 2-dehydrogenase
Identifiers
EC number	1.1.1.140
CAS number	37250-69-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a sorbitol-6-phosphate dehydrogenase (EC 1.1.1.140) is an enzyme that catalyzes the chemical reaction

D-sorbitol 6-phosphate + NAD⁺ $\rightleftharpoons$ D-fructose 6-phosphate + NADH + H⁺

Thus, the two substrates of this enzyme are D-sorbitol 6-phosphate and NAD⁺, whereas its 3 products are D-fructose 6-phosphate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is D-sorbitol-6-phosphate:NAD+ 2-oxidoreductase. Other names in common use include ketosephosphate reductase, ketosephosphate reductase, D-sorbitol 6-phosphate dehydrogenase, D-sorbitol-6-phosphate dehydrogenase, sorbitol-6-P-dehydrogenase, and D-glucitol-6-phosphate dehydrogenase. This enzyme participates in fructose and mannose metabolism.

References

• Du Toit PJ, Kotze JP (1970). "The isolation and characterization of sorbitol-6-phosphate dehydrogenase from Clostridium pasteurianum". Biochim. Biophys. Acta. 206 (3): 333–42. PMID 4318899. 
• LISS M, HORWITZ SB, KAPLAN NO (1962). "D-Mannitol 1-phosphate dehydrogenase and D-sorbitol 6-phosphate dehydrogenase in Aerobacter aerogenes". J. Biol. Chem. 237: 1342–50. PMID 14465816.