Zografou is an inner suburb of Athens, located about 4 km east of Athens city centre. Towards the east the municipality extends to the forested Hymettus mountain. The built-up area of Zografou is continuous with that of Athens. A large campus of the National and Kapodistrian University of Athens is situated in Ano Ilisia, the easternmost quarter of Zografou. Ano Ilisia derived its name from the river Ilisos, which starts at St Eleousa, now in the University campus. Another quarter of Zografou is Goudi, in the northwestern part of the municipality. The main church of Zografou is consecrated to Agios Therapontas (Greek: Άγιος Θεράποντας).
After the departure of the Ottomans from the area in the 1830s, the area came into the ownership of Ioannis Koniaris, mayor of Athens from 1851–1854, and Leonidas Vournazos.
In 1902, Eleni Vournazos, widow of Leonidas, sells 1,250 stremma of the Kouponia/Goudi area to Ioannis Zografos (d. 1927), a Member of Parliament for the Nationalist Party and university professor. Dividing it into plots, he sold them for installments of 112 drachma per month. The first houses were erected in 1919. Within ten years, 100 had been built. At this time, the foundations of the Church of St. Theraponta were erected.
In 1929, the area, now known as Zografou, was split from the city of Athens and became an independent community. It was elevated to a municipality in 1947. its first president being Sotirios Zografos, the son of Ioannis. In 1935, the area of Kouponia (now Ano Ilisia) was incorporated into the community.