Jump to content

Chlorphenamine: Difference between revisions

From Wikipedia, the free encyclopedia
Content deleted Content added
m clean up, Replaced: ® → (9) using AWB
No edit summary
Line 31: Line 31:
The halogenated alkylamine antihistamines all exhibit optic isomerism and chlorpheniramine in the indicated products is racemic chlorpheniramine maleate whereas [[dexchlorpheniramine]] (Polaramine) is the dextrorotary (right-handed) stereoisomer.
The halogenated alkylamine antihistamines all exhibit optic isomerism and chlorpheniramine in the indicated products is racemic chlorpheniramine maleate whereas [[dexchlorpheniramine]] (Polaramine) is the dextrorotary (right-handed) stereoisomer.


Chlorphenamine has [[antidepressant]] properties, inhibiting [[reuptake]] of the [[neurotransmitter]] [[serotonin]]. Based on this knowledge, the [[Sweden|Swedish]] company [[AstraZeneca|Astra AB]] was able to derive the first marketed [[selective serotonin reuptake inhibitor]], [[zimelidine]], from chlorphenamine. Like other agents of this type, it also has analgesic-sparing (potentiating) effects on opioid analgesics, commonly reducing codeine, dihydrocodeine, and hydrocodone requirements by 10 to 35 per cent.
Chlorphenamine has [[antidepressant]] properties, inhibiting [[reuptake]] of the [[neurotransmitter]] [[serotonin]]. Based on this knowledge, the [[Sweden|Swedish]] company [[AstraZeneca|Astra AB]] was able to derive the first marketed [[selective serotonin reuptake inhibitor]], [[zimelidine]], from [[brompheniramine]]. Like other agents of this type, it also has analgesic-sparing (potentiating) effects on opioid analgesics, commonly reducing codeine, dihydrocodeine, and hydrocodone requirements by 10 to 35 per cent.


Also known as "Comakin" in Taiwan and parts of Asia.
Also known as "Comakin" in Taiwan and parts of Asia.{{fact}}


==See also==
==See also==

Revision as of 06:28, 23 April 2008

Chlorphenamine
Clinical data
Pregnancy
category
  • AU: A
Routes of
administration
Oral, IV, IM, SC
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability25 to 50%
Protein binding72%
MetabolismHepatic (CYP2D6)
Elimination half-life21-27 hours
ExcretionRenal
Identifiers
  • 3-(4-chlorophenyl)-N,N-dimethyl-
    3-pyridin-2-yl-propan-1-amine
CAS Number
PubChem CID
DrugBank
CompTox Dashboard (EPA)
ECHA InfoCard100.004.596 Edit this at Wikidata
Chemical and physical data
FormulaC16H19ClN2
Molar mass274.788 g/mol g·mol−1
Solubility in water0.55 g/100 mL, liquid mg/mL (20 °C)

Chlorphenamine (INN) or chlorpheniramine (USAN, former BAN), commonly marketed as its salt chlorphenamine maleate (CPM; Chlor-Trimeton, Piriton, Chlor-Tripolon), is a first-generation alkylamine antihistamine used in the prevention of the symptoms of allergic conditions such as rhinitis and urticaria. Its sedative effects are relatively weak compared to other first-generation antihistamines. Chlorpheniramine is one of the most commonly used antihistamines in small-animal veterinary practice as well.

Chlorpheniramine is part of a series of antihistamines including pheniramine (Naphcon) and its halogenated derivatives and others including fluorpheniramine, chlorpheniramine, dexchlorpheniramine (Polaramine), brompheniramine (Dimetapp), dexbrompheniramine (Drixoral) deschlorpheniramine, dipheniramine (also known as triprolidine with the trade name Actifed) iodopheniramine &c.

The halogenated alkylamine antihistamines all exhibit optic isomerism and chlorpheniramine in the indicated products is racemic chlorpheniramine maleate whereas dexchlorpheniramine (Polaramine) is the dextrorotary (right-handed) stereoisomer.

Chlorphenamine has antidepressant properties, inhibiting reuptake of the neurotransmitter serotonin. Based on this knowledge, the Swedish company Astra AB was able to derive the first marketed selective serotonin reuptake inhibitor, zimelidine, from brompheniramine. Like other agents of this type, it also has analgesic-sparing (potentiating) effects on opioid analgesics, commonly reducing codeine, dihydrocodeine, and hydrocodone requirements by 10 to 35 per cent.

Also known as "Comakin" in Taiwan and parts of Asia.[citation needed]

See also

File:DSC000776.JPG
Chlorphenamine 4mg from U.K.

References