Epinastine

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Epinastine
Epinastine.svg
Epinastine-3D-balls.png
Clinical data
Trade names Alesion, Elestat, Purivist, Relestat
AHFS/Drugs.com Monograph
MedlinePlus a604011
Pregnancy
category
  • C
Routes of
administration
Eye drops
ATC code
Pharmacokinetic data
Protein binding 64%
Biological half-life 12 hours
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
ECHA InfoCard 100.120.187
Chemical and physical data
Formula C16H15N3
Molar mass 249.311 g/mol
3D model (Jmol)
  (verify)

Epinastine (brand names Alesion, Elestat, Purivist, Relestat) is a second-generation antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. It is produced by Allergan and marketed by Inspire in the United States.[1] It is highly selective for the H1 receptor and does not cross the blood-brain-barrier.[2]

References[edit]

  1. ^ Pradhan, S; Abhishek, K; Mah, F (2009). "Epinastine: topical ophthalmic second generation antihistamine without significant systemic side effects". Expert opinion on drug metabolism & toxicology. 5 (9): 1135–40. doi:10.1517/17425250903117284. PMID 19630694. 
  2. ^ Walther G, Daniel H, Bechtel WD, Brandt K (April 1990). "New tetracyclic guanidine derivatives with H1-antihistaminic properties. Chemistry of epinastine". Arzneimittel-Forschung. 40 (4): 440–6. PMID 1972625. 

External links[edit]