Neurophysin I: Difference between revisions
replaced protein box with GNF_protein_box; moved mutation data from this article to the neurophysin II article; + citation |
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'''Neurophysin I''' is a carrier [[protein]] with a size of 10 K[[Atomic mass unit|Da]] and containing 90 to 97 [[aminoacid]]s that is a cleavage product of preprooxyphysin.<ref name="pmid1486803">{{cite journal | author = Rao VV, Löffler C, Battey J, Hansmann I | title = The human gene for oxytocin-neurophysin I (OXT) is physically mapped to chromosome 20p13 by in situ hybridization | journal = Cytogenet. Cell Genet. | volume = 61 | issue = 4 | pages = 271–3 | year = 1992 | pmid = 1486803 | doi = | url = | issn = }}</ref> It is a neurohypophysial [[hormone]] that is transported in vesicles with [[oxytocin]], the other cleavage product, along [[axon]]s, from magnocellular neurons of the [[hypothalamus]] to the posterior lobe of the [[pituitary]]. Although it is stored in secretory vesicles with oxytocin and released with oxytocin, its biological action is unclear. |
'''Neurophysin I''' is a carrier [[protein]] with a size of 10 K[[Atomic mass unit|Da]] and containing 90 to 97 [[aminoacid]]s that is a cleavage product(formed by splitting of a compound molecule into a simpler one) of preprooxyphysin.<ref name="pmid1486803">{{cite journal | author = Rao VV, Löffler C, Battey J, Hansmann I | title = The human gene for oxytocin-neurophysin I (OXT) is physically mapped to chromosome 20p13 by in situ hybridization | journal = Cytogenet. Cell Genet. | volume = 61 | issue = 4 | pages = 271–3 | year = 1992 | pmid = 1486803 | doi = | url = | issn = }}</ref> It is a neurohypophysial [[hormone]] that is transported in vesicles with [[oxytocin]], the other cleavage product, along [[axon]]s, from magnocellular neurons of the [[hypothalamus]] to the posterior lobe of the [[pituitary]]. Although it is stored in secretory vesicles with oxytocin and released with oxytocin, its biological action is unclear. |
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== Function == |
== Function == |
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Revision as of 01:25, 8 May 2011
Template:PBB Neurophysin I is a carrier protein with a size of 10 KDa and containing 90 to 97 aminoacids that is a cleavage product(formed by splitting of a compound molecule into a simpler one) of preprooxyphysin.[1] It is a neurohypophysial hormone that is transported in vesicles with oxytocin, the other cleavage product, along axons, from magnocellular neurons of the hypothalamus to the posterior lobe of the pituitary. Although it is stored in secretory vesicles with oxytocin and released with oxytocin, its biological action is unclear.
Function
Neurophysins are carrier proteins for oxytocin and vasopressin (ADH). Oxytocin and vasopressin are carried by unique neurophysins from their site of production in the cell bodies of the paraventricular and supraoptic nuclei to their site of release in the axon terminals of the posterior pituitary.
References
- ^ Rao VV, Löffler C, Battey J, Hansmann I (1992). "The human gene for oxytocin-neurophysin I (OXT) is physically mapped to chromosome 20p13 by in situ hybridization". Cytogenet. Cell Genet. 61 (4): 271–3. PMID 1486803.
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