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Insulin-like growth factor binding protein 2, 36kDa
Protein IGFBP2 PDB 2h7t.png
PDB rendering based on 2h7t.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols IGFBP2 ; IBP2; IGF-BP53
External IDs OMIM146731 MGI96437 HomoloGene499 ChEMBL: 3088 GeneCards: IGFBP2 Gene
RNA expression pattern
PBB GE IGFBP2 202718 at tn.png
More reference expression data
Species Human Mouse
Entrez 3485 16008
Ensembl ENSG00000115457 ENSMUSG00000039323
UniProt P18065 P47877
RefSeq (mRNA) NM_000597 NM_008342
RefSeq (protein) NP_000588 NP_032368
Location (UCSC) Chr 2:
216.63 – 216.66 Mb
Chr 1:
72.82 – 72.85 Mb
PubMed search [1] [2]

Insulin-like growth factor-binding protein 2 is a protein that in humans is encoded by the IGFBP2 gene.[1]


  1. ^ Zapf J, Kiefer M, Merryweather J, Musiarz F, Bauer D, Born W, Fischer JA, Froesch ER (Oct 1990). "Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF I administration and in extrapancreatic tumor hypoglycemia". J Biol Chem 265 (25): 14892–8. PMID 1697583. 

Further reading[edit]

  • Rajaram S, Baylink DJ, Mohan S (1997). "Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions.". Endocr. Rev. 18 (6): 801–31. doi:10.1210/er.18.6.801. PMID 9408744. 
  • Wolf E, Lahm H, Wu M, et al. (2000). "Effects of IGFBP-2 overexpression in vitro and in vivo.". Pediatr. Nephrol. 14 (7): 572–8. doi:10.1007/s004670000362. PMID 10912521. 
  • Chesik D, De Keyser J, Wilczak N (2007). "Insulin-like growth factor binding protein-2 as a regulator of IGF actions in CNS: implications in multiple sclerosis.". Cytokine Growth Factor Rev. 18 (3–4): 267–78. doi:10.1016/j.cytogfr.2007.04.001. PMID 17485236. 
  • Binkert C, Margot JB, Landwehr J, et al. (1992). "Structure of the human insulin-like growth factor binding protein-2 gene". Mol. Endocrinol. 6 (5): 826–36. doi:10.1210/me.6.5.826. PMID 1376411. 
  • Zhou J, Bondy C (1992). "Insulin-like growth factor-II and its binding proteins in placental development". Endocrinology 131 (3): 1230–40. doi:10.1210/en.131.3.1230. PMID 1380437. 
  • Ehrenborg E, Vilhelmsdotter S, Bajalica S, et al. (1991). "Structure and localization of the human insulin-like growth factor-binding protein 2 gene". Biochem. Biophys. Res. Commun. 176 (3): 1250–5. doi:10.1016/0006-291X(91)90420-C. PMID 1710112. 
  • Agarwal N, Hsieh CL, Sills D, et al. (1991). "Sequence analysis, expression and chromosomal localization of a gene, isolated from a subtracted human retina cDNA library, that encodes an insulin-like growth factor binding protein (IGFBP2)". Exp. Eye Res. 52 (5): 549–61. doi:10.1016/0014-4835(91)90056-K. PMID 1712312. 
  • Roghani M, Lassarre C, Zapf J, et al. (1991). "Two insulin-like growth factor (IGF)-binding proteins are responsible for the selective affinity for IGF-II of cerebrospinal fluid binding proteins". J. Clin. Endocrinol. Metab. 73 (3): 658–66. doi:10.1210/jcem-73-3-658. PMID 1714916. 
  • Clemmons DR, Snyder DK, Busby WH (1991). "Variables controlling the secretion of insulin-like growth factor binding protein-2 in normal human subjects". J. Clin. Endocrinol. Metab. 73 (4): 727–33. doi:10.1210/jcem-73-4-727. PMID 1716260. 
  • Roghani M, Segovia B, Whitechurch O, Binoux M (1993). "Purification from human cerebrospinal fluid of insulin-like growth factor binding proteins (IGFBPs). Isolation of IGFBP-2, an altered form of IGFBP-3 and a new IGFBP species". Growth Regul. 1 (3): 125–30. PMID 1726837. 
  • Rosenfeld RG, Pham H, Conover CA, et al. (1989). "Structural and immunological comparison of insulin-like growth factor binding proteins of cerebrospinal and amniotic fluids". J. Clin. Endocrinol. Metab. 68 (3): 638–46. doi:10.1210/jcem-68-3-638. PMID 2465304. 
  • Binkert C, Landwehr J, Mary JL, et al. (1989). "Cloning, sequence analysis and expression of a cDNA encoding a novel insulin-like growth factor binding protein (IGFBP-2)". EMBO J. 8 (9): 2497–502. PMC 401241. PMID 2479552. 
  • Ilvesmäki V, Blum WF, Voutilainen R (1994). "Insulin-like growth factor binding proteins in the human adrenal gland". Mol. Cell. Endocrinol. 97 (1–2): 71–9. doi:10.1016/0303-7207(93)90212-3. PMID 7511544. 
  • Zhou J, Bondy C (1993). "Anatomy of the human ovarian insulin-like growth factor system". Biol. Reprod. 48 (3): 467–82. doi:10.1095/biolreprod48.3.467. PMID 7680905. 
  • Han VK, Bassett N, Walton J, Challis JR (1996). "The expression of insulin-like growth factor (IGF) and IGF-binding protein (IGFBP) genes in the human placenta and membranes: evidence for IGF-IGFBP interactions at the feto-maternal interface". J. Clin. Endocrinol. Metab. 81 (7): 2680–93. doi:10.1210/jc.81.7.2680. PMID 8675597. 
  • Bach LA, Rechler MM (1996). "Measurement of insulin-like growth factor (IGF)-II binding to purified IGF binding proteins 1-6: comparison of charcoal adsorption and high performance size exclusion chromatography". Biochim. Biophys. Acta 1313 (1): 79–88. doi:10.1016/0167-4889(96)00053-5. PMID 8781553. 
  • Ho PJ, Baxter RC (1997). "Insulin-like growth factor-binding protein-2 in patients with prostate carcinoma and benign prostatic hyperplasia". Clin. Endocrinol. (Oxf) 46 (3): 333–42. doi:10.1046/j.1365-2265.1997.1100922.x. PMID 9156044. 
  • Wong MS, Fong CC, Yang M (1999). "Biosensor measurement of the interaction kinetics between insulin-like growth factors and their binding proteins". Biochim. Biophys. Acta 1432 (2): 293–301. doi:10.1016/S0167-4838(99)00106-5. PMID 10407151.