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A person with MS can have almost any neurological symptom or sign; with [[autonomic nervous system|autonomic]], visual, motor, and sensory problems being the most common.<ref name="pmid18970977"/> The specific symptoms are determined by the locations of the lesions within the nervous system, and may include [[hypoesthesia|loss of sensitivity]] or [[paresthesia|changes in sensation]] such as tingling, pins and needles or numbness, muscle weakness, [[clonus|very pronounced reflexes]], [[muscle spasms]], or difficulty in moving; difficulties with coordination and balance ([[ataxia]]); [[dysarthria|problems with speech]] or [[dysphagia|swallowing]], visual problems ([[nystagmus]], [[optic neuritis]] or [[diplopia]]), [[fatigue (physical)|fatigue]], [[acute pain|acute]] or [[chronic pain]], and bladder and bowel difficulties, among others.<ref name="pmid18970977"/> [[Cognitive]] difficulties and emotional symptoms such as [[clinical depression|depression]] or [[labile affect|unstable mood]] are also common.<ref name="pmid18970977"/> [[Uhthoff's phenomenon]], a worsening of symptoms due to exposure to higher than usual temperatures, and [[Lhermitte's sign]], an electrical sensation that runs down the back when bending the neck, are particularly characteristic of MS although not specific.<ref name="pmid18970977"/> The main measure of disability and symptom severity is the [[expanded disability status scale]] (EDSS), with other measures such as the [[multiple sclerosis functional composite]] being increasingly used in research.<ref>{{cite journal |author=Kurtzke JF |title=Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS) |journal=Neurology |volume=33 |issue=11 |pages=1444–52 |year=1983 |pmid=6685237 |doi=10.1212/WNL.33.11.1444 }}</ref><ref name="pmid10467378">{{cite journal |author=Amato MP, Ponziani G |title=Quantification of impairment in MS: discussion of the scales in use |journal=Mult. Scler. |volume=5 |issue=4 |pages=216–9 |year=1999 |month=August |pmid=10467378 |doi= |url=}}</ref><ref name="pmid12356200">{{cite journal |author=Rudick RA, Cutter G, Reingold S |title=The multiple sclerosis functional composite: a new clinical outcome measure for multiple sderosis trials |journal=Mult. Scler. |volume=8 |issue=5 |pages=359–65 |year=2002 |month=October |pmid=12356200 |doi= |url=}}</ref>
A person with MS can have almost any neurological symptom or sign; with [[autonomic nervous system|autonomic]], visual, motor, and sensory problems being the most common.<ref name="pmid18970977"/> The specific symptoms are determined by the locations of the lesions within the nervous system, and may include [[hypoesthesia|loss of sensitivity]] or [[paresthesia|changes in sensation]] such as tingling, pins and needles or numbness, muscle weakness, [[clonus|very pronounced reflexes]], [[muscle spasms]], or difficulty in moving; difficulties with coordination and balance ([[ataxia]]); [[dysarthria|problems with speech]] or [[dysphagia|swallowing]], visual problems ([[nystagmus]], [[optic neuritis]] or [[diplopia]]), [[fatigue (physical)|fatigue]], [[acute pain|acute]] or [[chronic pain]], and bladder and bowel difficulties, among others.<ref name="pmid18970977"/> [[Cognitive]] difficulties and emotional symptoms such as [[clinical depression|depression]] or [[labile affect|unstable mood]] are also common.<ref name="pmid18970977"/> [[Uhthoff's phenomenon]], a worsening of symptoms due to exposure to higher than usual temperatures, and [[Lhermitte's sign]], an electrical sensation that runs down the back when bending the neck, are particularly characteristic of MS although not specific.<ref name="pmid18970977"/> The main measure of disability and symptom severity is the [[expanded disability status scale]] (EDSS), with other measures such as the [[multiple sclerosis functional composite]] being increasingly used in research.<ref>{{cite journal |author=Kurtzke JF |title=Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS) |journal=Neurology |volume=33 |issue=11 |pages=1444–52 |year=1983 |pmid=6685237 |doi=10.1212/WNL.33.11.1444 }}</ref><ref name="pmid10467378">{{cite journal |author=Amato MP, Ponziani G |title=Quantification of impairment in MS: discussion of the scales in use |journal=Mult. Scler. |volume=5 |issue=4 |pages=216–9 |year=1999 |month=August |pmid=10467378 |doi= |url=}}</ref><ref name="pmid12356200">{{cite journal |author=Rudick RA, Cutter G, Reingold S |title=The multiple sclerosis functional composite: a new clinical outcome measure for multiple sderosis trials |journal=Mult. Scler. |volume=8 |issue=5 |pages=359–65 |year=2002 |month=October |pmid=12356200 |doi= |url=}}</ref>


[[File:Animal locomotion. Plate 559 (Boston Public Library) Animation all rows.gif|thumb|right|Animation created from a 1887 photographic study of locomotion of a MS male patient with walking difficulties by [[Muybridge]]]]
The condition begins in 85% of cases as a clinically isolated syndrome over a number of days with 45% having motor or sensory problems, 20% having optic neuritis, and 10% having symptoms related to [[brainstem]] dysfunction, while the remaining 20% have more than one of the previous difficulties.<ref name=Tsang2011/> The course of symptoms occurs in two main patterns initially; either as episodes of sudden worsening that last a few days to months (called [[relapse]]s, exacerbations, bouts, attacks, or "flare-ups") followed by improvement (85% of cases) or as a gradual worsening over time without periods of recovery (10-15% of cases).<ref name=Milo2010/> A combination of these two patterns may also occur<ref name="pmid8780061">{{cite journal|author=[[Fred D. Lublin|Lublin FD]], Reingold SC|title=Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis|journal=Neurology |volume=46 |issue=4|pages=907–11|year=1996|month=April|pmid=8780061|doi=10.1212/WNL.46.4.907}}</ref> or people may start in a relapsing and remitting course and switch to progressive course later on.<ref name=Milo2010/> Multiple sclerosis relapses are usually not predictable, occurring without warning.<ref name="pmid18970977"/> Exacerbations rarely occur more frequently than twice per year.<ref name="pmid18970977"/> Some attacks, however, are preceded by common triggers. Relapses occur more frequently during spring and summer.<ref name="pmid16804331">{{cite journal|author=Tataru N, Vidal C, Decavel P, Berger E, Rumbach L |title=Limited impact of the summer heat wave in France (2003) on hospital admissions and relapses for multiple sclerosis |journal=Neuroepidemiology |volume=27 |issue=1 |pages=28–32 |year=2006|pmid=16804331 |doi=10.1159/000094233}}</ref> and similarly, viral infections such as the [[common cold]], [[influenza]], or [[gastroenteritis]] increase their risk.<ref name="pmid18970977"/> [[Stress (medicine)|Stress]] may also trigger an attack.<ref name="pmid17439878">{{cite journal|author=Heesen C, Mohr DC, Huitinga I, ''et al.''|title=Stress regulation in multiple sclerosis: current issues and concepts|journal=Mult. Scler.|volume=13 |issue=2 |pages=143–8 |year=2007 |month=March |pmid=17439878 |doi=10.1177/1352458506070772}}</ref> Being pregnant decreases the risk of relapse. During the first months after delivery, however, the risk increases.<ref name="pmid18970977"/> Overall, pregnancy does not seem to influence long-term disability.<ref name="pmid18970977"/> Many events have not been found to affect relapse rates including vaccination, breast feeding,<ref name="pmid18970977"/> physical trauma,<ref name="pmid11205361">{{cite journal|author=Martinelli V |title=Trauma, stress and multiple sclerosis |journal=Neurol. Sci. |volume=21|issue=4 Suppl 2 |pages=S849–52|year=2000 |pmid=11205361 |doi=10.1007/s100720070024 |url=http://link.springer-ny.com/link/service/journals/10072/bibs/00214%20Suppl%202/0021S849.htm}}</ref> and Uhthoff's phenomenon.<ref name="pmid16804331"/>
The condition begins in 85% of cases as a clinically isolated syndrome over a number of days with 45% having motor or sensory problems, 20% having optic neuritis, and 10% having symptoms related to [[brainstem]] dysfunction, while the remaining 20% have more than one of the previous difficulties.<ref name=Tsang2011/> The course of symptoms occurs in two main patterns initially; either as episodes of sudden worsening that last a few days to months (called [[relapse]]s, exacerbations, bouts, attacks, or "flare-ups") followed by improvement (85% of cases) or as a gradual worsening over time without periods of recovery (10-15% of cases).<ref name=Milo2010/> A combination of these two patterns may also occur<ref name="pmid8780061">{{cite journal|author=[[Fred D. Lublin|Lublin FD]], Reingold SC|title=Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis|journal=Neurology |volume=46 |issue=4|pages=907–11|year=1996|month=April|pmid=8780061|doi=10.1212/WNL.46.4.907}}</ref> or people may start in a relapsing and remitting course and switch to progressive course later on.<ref name=Milo2010/> Multiple sclerosis relapses are usually not predictable, occurring without warning.<ref name="pmid18970977"/> Exacerbations rarely occur more frequently than twice per year.<ref name="pmid18970977"/> Some attacks, however, are preceded by common triggers. Relapses occur more frequently during spring and summer.<ref name="pmid16804331">{{cite journal|author=Tataru N, Vidal C, Decavel P, Berger E, Rumbach L |title=Limited impact of the summer heat wave in France (2003) on hospital admissions and relapses for multiple sclerosis |journal=Neuroepidemiology |volume=27 |issue=1 |pages=28–32 |year=2006|pmid=16804331 |doi=10.1159/000094233}}</ref> and similarly, viral infections such as the [[common cold]], [[influenza]], or [[gastroenteritis]] increase their risk.<ref name="pmid18970977"/> [[Stress (medicine)|Stress]] may also trigger an attack.<ref name="pmid17439878">{{cite journal|author=Heesen C, Mohr DC, Huitinga I, ''et al.''|title=Stress regulation in multiple sclerosis: current issues and concepts|journal=Mult. Scler.|volume=13 |issue=2 |pages=143–8 |year=2007 |month=March |pmid=17439878 |doi=10.1177/1352458506070772}}</ref> Being pregnant decreases the risk of relapse. During the first months after delivery, however, the risk increases.<ref name="pmid18970977"/> Overall, pregnancy does not seem to influence long-term disability.<ref name="pmid18970977"/> Many events have not been found to affect relapse rates including vaccination, breast feeding,<ref name="pmid18970977"/> physical trauma,<ref name="pmid11205361">{{cite journal|author=Martinelli V |title=Trauma, stress and multiple sclerosis |journal=Neurol. Sci. |volume=21|issue=4 Suppl 2 |pages=S849–52|year=2000 |pmid=11205361 |doi=10.1007/s100720070024 |url=http://link.springer-ny.com/link/service/journals/10072/bibs/00214%20Suppl%202/0021S849.htm}}</ref> and Uhthoff's phenomenon.<ref name="pmid16804331"/>


Revision as of 08:08, 17 July 2013

Multiple sclerosis
SpecialtyNeurology Edit this on Wikidata
Frequency0.032% (world)

Multiple sclerosis (MS), also known as disseminated sclerosis or encephalomyelitis disseminata, is an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged. This damage disrupts the ability of parts of the nervous system to communicate resulting in a wide range of signs and symptoms including:[1][2] physical, mental,[2] and sometimes psychiatric problems.[3] MS takes several forms, with new symptoms either occurring in isolated attacks (relapsing forms) or building up over time (progressive forms).[4] Between attacks, symptoms may go away completely; however, permanent neurological problems often occur, especially as the disease advances.[4]

While the cause is not clear, the underlying mechanism is thought to be either destruction by the immune system or failure of the myelin-producing cells.[5] Proposed causes for this include environmental factors such as infections and genetics.[2][6] MS is usually diagnosed based on the presenting signs and symptoms and the results of supporting medical tests.

There is no known cure for multiple sclerosis. Treatments attempt to improve function after an attack and prevent new attacks.[2] Medications used to treat MS while modestly effective can have adverse effects and be poorly tolerated. Many people pursue alternative treatments, despite a lack of evidence. The long term outcome is difficult to predict; with good outcomes more often seen in women, those who develop the disease early in life, those with a relapsing course, and those who initially experienced few attacks.[7] Life expectancy is 5 to 10 years lower than that of an unaffected population.[1]

As of 2008, between 2 and 2.5 million people are affected globally with rates varying widely in different regions of the world and among different populations.[8] The disease usually begins between the ages of 20 and 50 and is twice as common in women as men.[9] The name multiple sclerosis refers to scars (sclerae-—better known as plaques or lesions) particularly in the white matter of the brain and spinal cord.[10] MS was first described in 1868 by Jean-Martin Charcot.[10] A number of new treatments and diagnostic methods are under development.

Signs and symptoms

Main article: Multiple sclerosis signs and symptoms
Main symptoms of multiple sclerosis

A person with MS can have almost any neurological symptom or sign; with autonomic, visual, motor, and sensory problems being the most common.[1] The specific symptoms are determined by the locations of the lesions within the nervous system, and may include loss of sensitivity or changes in sensation such as tingling, pins and needles or numbness, muscle weakness, very pronounced reflexes, muscle spasms, or difficulty in moving; difficulties with coordination and balance (ataxia); problems with speech or swallowing, visual problems (nystagmus, optic neuritis or diplopia), fatigue, acute or chronic pain, and bladder and bowel difficulties, among others.[1] Cognitive difficulties and emotional symptoms such as depression or unstable mood are also common.[1] Uhthoff's phenomenon, a worsening of symptoms due to exposure to higher than usual temperatures, and Lhermitte's sign, an electrical sensation that runs down the back when bending the neck, are particularly characteristic of MS although not specific.[1] The main measure of disability and symptom severity is the expanded disability status scale (EDSS), with other measures such as the multiple sclerosis functional composite being increasingly used in research.[11][12][13]

Animation created from a 1887 photographic study of locomotion of a MS male patient with walking difficulties by Muybridge

The condition begins in 85% of cases as a clinically isolated syndrome over a number of days with 45% having motor or sensory problems, 20% having optic neuritis, and 10% having symptoms related to brainstem dysfunction, while the remaining 20% have more than one of the previous difficulties.[14] The course of symptoms occurs in two main patterns initially; either as episodes of sudden worsening that last a few days to months (called relapses, exacerbations, bouts, attacks, or "flare-ups") followed by improvement (85% of cases) or as a gradual worsening over time without periods of recovery (10-15% of cases).[9] A combination of these two patterns may also occur[4] or people may start in a relapsing and remitting course and switch to progressive course later on.[9] Multiple sclerosis relapses are usually not predictable, occurring without warning.[1] Exacerbations rarely occur more frequently than twice per year.[1] Some attacks, however, are preceded by common triggers. Relapses occur more frequently during spring and summer.[15] and similarly, viral infections such as the common cold, influenza, or gastroenteritis increase their risk.[1] Stress may also trigger an attack.[16] Being pregnant decreases the risk of relapse. During the first months after delivery, however, the risk increases.[1] Overall, pregnancy does not seem to influence long-term disability.[1] Many events have not been found to affect relapse rates including vaccination, breast feeding,[1] physical trauma,[17] and Uhthoff's phenomenon.[15]

Causes

The cause of MS is unknown; however, it is believed to occur as a result of some combination of environmental factors such as infectious agents and genetics.[1] Theories try to combine the data into likely explanations, but none has proved definitive. While there are a number of environmental risk factors and although some are partly modifiable, further research is needed to determine whether their elimination can prevent MS.[18]

Geography

MS is more common in people who live farther from the equator, although exceptions exist.[1][19] These exceptions include ethnic groups that are at low risk far from the equator such as the Samis, Amerindians, Canadian Hutterites, New Zealand Māori,[20] and Canada's Inuit.[9] And groups that have a relatively high risk close to the equator such as Sardinians,[9] Palestinians and Parsis.[20] The cause of this geographical pattern is not clear.[9] While the north south gradient is becoming less[19] as of 2010 it is still present.[9]

MS is more common in regions with northern European populations[1] and the geographic variation may simply reflect the global distribution of these high risk populations.[9] Decreased sunlight exposure resulting in decreased vitamin D production has also been put forwards as an explanation.[21][22] A relationship between season of birth and MS lends support to this idea, with fewer people born in the northern hemisphere in November as compared to May being affected latter in life.[23] Environmental factors during childhood may play a role with several studies finding that people who move to a different region of the world before the age of 15 acquiring the new region's risk to MS. If migration takes place after age 15; however, the person retains the risk of his home country.[1][18] However, the age–geographical risk may span a larger timescale.[1]

Genetics

HLA region of Chromosome 6. Changes in this area increase the probability of suffering MS.

MS is not considered a hereditary disease; however, a number of genetic variations have been shown to increase the risk.[24] The probability of MS is higher in relatives of an affected person, with a greater risk among those who are more closely related.[2] In identical twins both are affected about 30% of the time, while around 5% for non identical twins and 2.5% of siblings are affected with a lower percentage of half-siblings.[1][2][25] If both parents are affected the risk in their children is 10 times that of the general population.[9] MS is also more common in some ethnic groups than others.[26]

Specific genes that have been linked with MS include differences in the human leukocyte antigen (HLA) system—a group of genes on chromosome 6 that serves as the major histocompatibility complex (MHC).[1] That changes in the HLA region are related to the susceptibility for MS has been known for over thirty years,[27] and additionally this same region has been implicated in the development of other autoinmmune diseases such as diabetes type I and systemic lupus erythematosus.[27] The most consistent finding is the association between multiple sclerosis andalleles of the MHC defined as DR15 and DQ6.[1] Other loci have shown a protective effect, such as HLA-C554 and HLA-DRB1*11.[1] Overall, it has been estimated that HLA changes accounts for between 20 and 60% of the genetic predisposition for MS.[27] Modern genetic methods (genome-wide association studies) have discovered at least twelve other genes outside the HLA locus that modestly increase the probability of MS.[27]

Infectious agents

Many microbes have been proposed as triggers of MS, but none have been confirmed.[2] Moving at an early age from one location in the world to another alters a person's subsequent risk of MS.[6] An explanation for this could be that some kind of infection, produced by a widespread microbe rather than a rare one, is related to the disease.[6] Proposed mechanisms include the hygiene hypothesis and the prevalence hypothesis. The hygiene hypothesis proposes that exposure to several infectious agents early in life is protective against MS, the disease being a response to a late encounter with such agents.[1] The prevalence hypothesis proposes that the disease is due to an infectious agent more common in regions where MS is common and where in most individuals it causes an ongoing infection without symptoms. Only in a few cases and after many years does it cause demyelination.[6][28] The hygiene hypothesis has received more support than the prevalence hypothesis.[6]

Evidence for viruses as a cause include: the presence of oligoclonal bands in the brain and cerebrospinal fluid of most people with MS, the association of several viruses with human demyelination encephalomyelitis, and the occurrence of demyelination in animals caused by some viral infection.[29]Human herpes viruses are a candidate group of viruses. Individuals who have never been infected by the Epstein-Barr virus have a reduced risk of having the disease, and those infected as young adults have a greater risk than those who had it at a younger age.[1][6] Although some consider that this goes against the hygiene hypothesis, since the noninfected have probably experienced a more hygienic upbringing,[6] others believe that there is no contradiction since it is a first encounter at a later moment with the causative virus that is the trigger for the disease.[1] Other diseases that have been related with MS include: measles, mumps, and rubella.[1]

Other

Stress may be a risk factor although the evidence to support this is weak.[18] Smoking has also been shown to be an independent risk factor.[21] Association with occupational exposures and toxins—mainly solvents—has been evaluated, but no clear conclusions have been reached.[18] Vaccinations were investigated as causal factors; however, most studies show no association.[18] Several other possible risk factors, such as diet andhormone intake, have been investigated; however, evidence on their relation with the disease is "sparse and unpersuasive".[21] Gout occurs less than would be expected, and lower levels of uric acid have been found in people with MS. This has led to the theory that uric acid is protective, although its exact importance remains unknown.[30]

Pathophysiology

Main article: Pathophysiology of multiple sclerosis

The three main characteristics of MS are the formation of lesions in the central nervous system (also called plaques), inflammation, and the destruction of myelin sheaths of neurons. These features interact in a complex and not yet fully understood manner to produce the break down of nerve tissue and in turn the signs and symptoms of the disease.[1] Additionally MS is believed to be an immune-mediated disorder that develops from a complex interaction of the individual's genetics and as yet unidentified environmental causes.[2] Damage is believed to be caused, at least in part, by the person's own immune system attacking the nervous system.[1]

Lesions

Demyelination in MS. On Klüver-Barrera myelin staining, decoloration in the area of the lesion can be appreciated (Original scale 1:100).

The name multiple sclerosis refers to the scars (sclerae – better known as plaques or lesions) that form in the nervous system. MS lesions most commonly involve white matter in the optic nerve, brain stem, basal ganglia and spinal cord, or white matter tracts close to the lateral ventricles.[1] The function of white matter cells is to carry signals between grey matter areas, where the processing is done, and the rest of the body. The peripheral nervous system is rarely involved.[2]

More specifically, MS involves the loss of oligodendrocytes, the cells responsible for creating and maintaining a fatty layer—known as the myelin sheath—which helps the neurons carry electrical signals (action potentials).[1] This results in a thinning or complete loss of myelin and, as the disease advances, the breakdown of the neuron's axons. When the myelin is lost, a neuron can no longer effectively conduct electrical signals.[2] A repair process, called remyelination, takes place in early phases of the disease, but the oligodendrocytes are unable to completely rebuild the cell's myelin sheath.[31] Repeated attacks lead to successively less effective remyelinations, until a scar-like plaque is built up around the damaged axons.[31] These scars are the origin of the symptoms and during an attack magnetic resonance imaging (MRI) often shows more than ten new plaques.[1] This could indicate that there is a number of lesions below which the brain is capable of repairing itself without producing noticeable consequences.[1] Another process involved in the creation of lesions is an abnormal increase in the number of astrocytes due to the destruction of nearby neurons.[1] A number of lesion patterns have been described.[32]

Inflammation

Apart from demyelination, the other pathologic hallmark of the disease is inflammation. Fitting with an immunological explanation, the inflammatory process is caused by T cells, a kind of lymphocyte that plays an important role in the body's defenses.[2] T cells gain entry into the brain via disruptions in the blood–brain barrier. The T cells recognize myelin as foreign and attack it, explaining why these cells are also called "autoreactive lymphocytes".[1]

The attack of myelin starts inflammatory processes which triggers other immune cells and the release of soluble factors like cytokines and antibodies. Further break down of the blood–brain barrier, in turn cause a number of other damaging effects such as swelling, activation of macrophages, and more activation of cytokines and other destructive proteins.[2] Inflammation can potentially reduce transmission of information between neurons in at least three ways.[1] The soluble factors released might stop neurotransmission by intact neurons. These factors could lead to or enhance the loss of myelin. Or they may cause the axon to break down completely.[1]

The blood–brain barrier is a part of the capillary system that prevents the entry of T cells into the central nervous system. It may become permeable to these types of cells secondary to an infection by a virus or bacteria. After it repairs itself, typically once the infection has cleared, T cells may remain trapped inside the brain.[2]

Diagnosis

Animation showing dissemination of brain lesions in time and space as demonstrated by monthly MRI studies along a year

Multiple sclerosis is typically diagnosed based the presenting signs and symptoms in combination with supporting medical imaging and laboratory testing.[14] It can be difficult to confirm, especially early on, since the signs and symptoms may be similar to other medical problems.[1][33] The McDonald criteria which focus on clinical, laboratory and radiologic evidence of lesions at different times and in different areas is the most commonly used method of diagnosis[8] with the Schumacher and Poser criteria being of mostly historical significance.[34] While the above criteria allow for a non-invasive diagnosis, some state that the only definitive proof is an autopsy or biopsy where lesions typical of MS are detected.[1][35][36]

Clinical data alone may be sufficient for a diagnosis of MS if an individual has had separate episodes of neurologic symptoms characteristic of the disease.[35] In those who seek medical attention after only one attack, other testing is needed for the diagnosis. The most commonly used diagnostic tools are neuroimaging, analysis of cerebrospinal fluid and evoked potentials. Magnetic resonance imaging of the brain and spine may show areas of demyelination (lesions or plaques). Gadolinium can be administered intravenously as a contrast to highlight active plaques and, by elimination, demonstrate the existence of historical lesions not associated with symptoms at the moment of the evaluation.[35][37] Testing of cerebrospinal fluid obtained from a lumbar puncture can provide evidence of chronic inflammation of the central nervous system. The cerebrospinal fluid is tested for oligoclonal bands of IgG on electrophoresis, which are inflammation markers found in 75–85% of people with MS.[35][38] The nervous system in MS may respond less actively to stimulation of the optic nerve and sensory nerves due to demyelination of such pathways. These brain responses can be examined using visual and sensory evoked potentials.[39]

Clinical courses

Progression of MS subtypes

Several subtypes, or patterns of progression, have been described. Subtypes use the past course of the disease in an attempt to predict the future course. They are important not only for prognosis but also for therapeutic decisions. In 1996 the United States National Multiple Sclerosis Society standardized four clinical courses:[4]

  1. relapsing remitting,
  2. secondary progressive,
  3. primary progressive, and
  4. progressive relapsing.

The relapsing-remitting subtype is characterized by unpredictable relapses followed by periods of months to years of relative quiet (remission) with no new signs of disease activity. Deficits that occur during attacks may either resolve or leave sequelae, the latter in about 40% of attacks and being more common the longer a person has had the disease.[1][14] This describes the initial course of 80% of individuals with MS.[1] When deficits always resolve between attacks, this is sometimes referred to as benign MS,[40] although people will still accrue some degree of disability in the long term.[1] On the other hand, the term malignant multiple sclerosis is used to describe MS patients who reach significant level of disability in a short period of time.[41] The relapsing-remitting subtype usually begins with a clinically isolated syndrome (CIS). In CIS, a person has an attack suggestive of demyelination, but does not fulfill the criteria for multiple sclerosis.[1][42] 30 to 70% of persons experiencing CIS later develop MS.[42]

Nerve axon with myelin sheath

Secondary progressive MS occurs in around 65% of those with initial relapsing-remitting MS, who eventually have progressive neurologic decline between acute attacks without any definite periods of remission.[1][4] Occasional relapses and minor remissions may appear.[4] The median time between disease onset and conversion from relapsing-remitting to secondary progressive MS is 19 years.[43] The primary progressive subtype occurs in approximately 10–20% of individuals, with no remission after the initial MS symptoms.[44][14] It is characterized by progression of disability from onset, with no, or only occasional and minor, remissions and improvements.[4] The age of onset for the primary progressive subtype is later than for the relapsing-remitting, but similar to mean age of progression between the relapsing-remitting and the secondary progressive. In both cases it is around 40 years of age.[1]

Progressive relapsing MS describes those individuals who, from onset, have a steady neurologic decline but also suffer clear superimposed attacks. This is the least common of all subtypes.[4]

Unusual types of MS have been described; these include Devic's disease, Balo concentric sclerosis, Schilder's diffuse sclerosis and Marburg multiple sclerosis. There is debate on whether they are MS variants or different diseases.[45] Multiple sclerosis also behaves differently in children, taking more time to reach the progressive stage.[1] Nevertheless they still reach it at a lower average age than adults.[1]

Management

Main article: Management of multiple sclerosis

Although there is no known cure for multiple sclerosis, several therapies have proven helpful. The primary aims of therapy are returning function after an attack, preventing new attacks, and preventing disability. As with any medical treatment, medications used in the management of MS have several adverse effects. Alternative treatments are pursued by some people, despite the shortage of supporting evidence.

Acute attacks

During symptomatic attacks, administration of high doses of intravenous corticosteroids, such as methylprednisolone, is the usual therapy,[1] with oral corticosteroids seeming to have a similar efficacy and safety profile.[46] Although generally effective in the short term for relieving symptoms, corticosteroid treatments do not appear to have a significant impact on long-term recovery.[47] The consequences of severe attacks which do not respond to corticosteroids might be treatable by plasmapheresis.[1]

Disease-modifying treatments

Relapsing remitting multiple sclerosis

Eight disease-modifying treatments have been approved by regulatory agencies for relapsing-remitting multiple sclerosis (RRMS) including: interferon beta-1a, interferon beta-1b, glatiramer acetate, mitoxantrone, natalizumab, fingolimod,[48] teriflunomide[49] and dimethyl fumarate.[50] Their cost effectiveness as of 2012 is unclear.[51]

In RRMS they are modestly effective at decreasing the number of attacks.[48] The interferons and glatiramer acetate are first line treatments[14] and are roughly equivalent, reducing relapses by approximately 30%.[52] Early-initiated long-term therapy is safe and improves outcomes.[53][54] Natalizumab reduces the relapse rate more than first line agents; however, due to issues of adverse effects is a second line agent reserved for those who do not respond to other treatments[14] or with severe disease.[52] Mitoxantrone, whose use is limited by severe adverse effects, is a third line option for those who do not respond to other medications.[14] Treatment of clinically isolated syndrome (CIS) with interferons decreases the chance of progressing to clinical MS.[1][55] Efficacy of interferons and glatiramer acetate in those with MS before eighteen years of age has been estimated to be roughly equivalent to that of adults.[56] The role of some of the newer agents such as fingolimod, teriflunomide, and dimethyl fumarate as of 2011 is not yet entirely clear.[57]

Progressive multiple sclerosis

No treatment has been shown to change the course of primary progressive MS[14] and as of 2011 only one medication, mitoxantrone, has been approved for secondary progressive MS.[58] In this population tentative evidence supports mitoxantrone moderately slowing the progression of the disease and decreasing rates of relapses over two years.[59][60]

Adverse effects

Irritation zone after injection of glatiramer acetate.

The disease-modifiying treatments have several adverse effects. One of the most common is irritation at the injection site for glatiramer acetate and the interferons (up to 90% with subcutaneous injections and 33% with intramuscular injections).[61] Over time, a visible dent at the injection site, due to the local destruction of fat tissue, known as lipoatrophy, may develop.[61] Interferons may produce symptoms similar to influenza;[62] some people taking glatiramer experience a post-injection reaction with flushing, chest tightness, heart palpitations, breathlessness, and anxiety, which usually lasts less than thirty minutes.[63] More dangerous but much less common are liver damage from interferons,[64] systolic dysfunction (12%), infertility, and acute myeloid leukemia (0.8%) from mitoxantrone,[59][65] and progressive multifocal leukoencephalopathy occurring with natalizumab (occurring in 1 in 600 people treated).[14][66]

Fingolimod may give rise to hypertension and bradycardia, macular edema, elevated liver enzymes or reduction in lymphocite levels.[67] Tentative evidence supports the short term safety of teriflunomide, with common side effects including: headaches, fatigue, nausea, hair loss, and limb pain.[48] Additionally there have been reports of liver failure and PML and it is dangerous for fetal development.[67] Most common secondary effects of dimethyl fumarate are flushing and gastrointestinal problems.[50][67] While dimethyl fumarate may lead to a reduction in the white blood cell count there were no reported cases of opportunistic infections during clinical trials.[68][69]

Associated symptoms

Both drug therapy and neurorehabilitation have been shown to improve some symptoms, though neither changes the course of the disease.[70] Some symptoms have a good response to medication, such as an unstable bladder and spasticity, while others are little changed.[1] For neurologic problems, a multidisciplinary approach is important for improving quality of life; however, it is difficult to specify a 'core team' as many different health services may be needed at different times.[1] Multidisciplinary rehabilitation programs increase activity and participation of people with MS but do not influence impairment level.[71] There is limited evidence for the overall efficacy of individual therapeutic disciplines,[72][72][73] though there is good evidence that specific approaches, such as exercise,[74][75] and psychology therapies, particularly cognitive behavioral approaches are effective.[76]

Alternative treatments

Over 50% of people with MS may use complementary and alternative medicine, although percentages vary depending on how alternative medicine is defined.[77] The evidence for the effectiveness for such treatments in most cases is weak or absent.[77][78] While there is tentative evidence that vitamin D may be useful, evidence is insufficient for a definitive conclusion.[79] Treatments of unproven benefit used by people with MS include: dietary supplementation and regimens,[77][80][81] relaxation techniques such as yoga,[77] herbal medicine (including medical cannabis),[77][82] hyperbaric oxygen therapy,[83] self-infection with hookworms, reflexology and acupunture.[77][84] Regarding the characteristics of users, they are more frequently women, have had MS for a longer time, tend to be more disabled and have lower levels of satisfaction with conventional healthcare.[77]

Prognosis

Disability-adjusted life year for multiple sclerosis per 100,000 inhabitants in 2004 Template:Multicol
  no data
  <13
  13–16
  16–19
  19–22
  22–25
  25–28
Template:Multicol-break
  28–31
  31–34
  34–37
  37–40
  40–43
  >43
Template:Multicol-end

The expected future course of the disease depends on the subtype of the disease; the individual's sex, age, and initial symptoms; and the degree of disability the person has.[7] Female sex, relapsing-remitting subtype, optic neuritis or sensory symptoms at onset, few attacks in the initial years and especially early age at onset, are associated with a better course.[7][85]

The average life expectancy is 30 years from onset, being 5 to 10 years lower than that of unaffected people.[1] Almost 40% of people with MS reach the seventh decade of life.[85] Nevertheless, two-thirds of the deaths are directly related to the consequences of the disease.[1] Suicide is more common, while infections and other complications are especially dangerous for the more disabled.[1] Although most people lose the ability to walk before death, 90% are capable of independent walking at 10 years from onset, and 75% at 15 years.[85][86]

Epidemiology

The number of people with MS, as of 2010, is 2-2.5 million (approximately 30 per 100,000) globally, with rates varying widely in different regions.[8][9] In Africa rates are less than 0.5 per 100,000, while they are 2.8 per 100,000 in South East Asia, 8.3 per 100,000 in the Americas, and 80 per 100,000 in Europe.[8] Rates surpass 200 per 100,000 in certain populations of Northern European descent.[9] Rates of MS appear to be increasing, this however may be explained simply by better diagnosis.[9] Studies on populational and geographical patterns have been common[28] and have led to a number of theories about the cause.[6][18][21]

MS usually appears in adults in their late twenties or early thirties but it can rarely start in childhood and after 50 years of age.[8][9] The primary progressive subtype is more common in people in their fifties.[44] Similar to many autoimmune disorders, the disease is more common in women, and the trend may be increasing.[1][19] As of 2008 globally it is about two times more common in women than in men.[8] In children, it is even more common in females than males,[1] while in people over fifty, it affects males and females almost equally.[44]

History

Medical discovery

Detail of Carswell's drawing of MS lesions in the brain stem and spinal cord (1838)

The French neurologist Jean-Martin Charcot (1825–1893) was the first person to recognize multiple sclerosis as a distinct disease in 1868.[87] Summarizing previous reports and adding his own clinical and pathological observations, Charcot called the disease sclerose en plaques. The three signs of MS now known as Charcot's triad 1 are nystagmus, intention tremor, and telegraphic speech (scanning speech), though these are not unique to MS. Charcot also observed cognition changes, describing his patients as having a "marked enfeeblement of the memory" and "conceptions that formed slowly".[10]

Before Charcot, Robert Carswell (1793–1857), a British professor of pathology, and Jean Cruveilhier (1791–1873), a French professor of pathologic anatomy, had described and illustrated many of the disease's clinical details, but did not identify it as a separate disease.[87] Specifically, Carswell described the injuries he found as "a remarkable lesion of the spinal cord accompanied with atrophy".[1] Under the microscope, Swiss pathologist Georg Eduard Rindfleisch (1836–1908) noted in 1863 that the inflammation-associated lesions were distributed around blood vessels.[88][89]

After Charcot's description, Eugène Devic (1858–1930), Jozsef Balo (1895–1979), Paul Ferdinand Schilder (1886–1940), and Otto Marburg (1874–1948) described special cases of the disease. During all the 20th century there was an important development on the theories about the cause and pathogenesis of MS while efficacious treatments began to appear in 1990.[1]

Historical cases

Photographic study of locomotion of a MS female patient with walking difficulties created in 1887 by Muybridge

There are several historical accounts of people who lived before or shortly after the disease was described by Charcot and probably had MS.

A young woman called Halldora who lived in Iceland around 1200 suddenly lost her vision and mobility but, after praying to the saints, recovered them seven days after. Saint Lidwina of Schiedam (1380–1433), a Dutch nun, may be one of the first clearly identifiable MS patients. From the age of 16 until her death at 53, she suffered intermittent pain, weakness of the legs, and vision loss—symptoms typical of MS.[90] Both cases have led to the proposal of a 'Viking gene' hypothesis for the dissemination of the disease.[91]

Augustus Frederick d'Este (1794–1848), son of Prince Augustus Frederick, Duke of Sussex and Lady Augusta Murray and the grandson of George III of the United Kingdom, almost certainly suffered from MS. D'Este left a detailed diary describing his 22 years living with the disease. His diary began in 1822 and ended in 1846, although it remained unknown until 1948. His symptoms began at age 28 with a sudden transient visual loss (amaurosis fugax) after the funeral of a friend. During the course of his disease, he developed weakness of the legs, clumsiness of the hands, numbness, dizziness, bladder disturbances, and erectile dysfunction. In 1844, he began to use a wheelchair. Despite his illness, he kept an optimistic view of life.[92][93]

Another early account of MS was kept by the British diarist W. N. P. Barbellion, nom-de-plume of Bruce Frederick Cummings (1889–1919), who maintained a detailed log of his diagnosis and struggle with MS.[93] His diary was published in 1919 as The Journal of a Disappointed Man.[94]

Research

Main article: Multiple sclerosis research

Medications

Chemical structure of alemtuzumab

There is ongoing research looking for more effective, convenient, and tolerable treatments for RRMS; creation of therapies for the progressive subtypes; neuroprotection strategies; and effective symptomatic treatments.[95]

During the 2000s and 2010s there has been approval of several oral drugs which are expected to gain in popularity and frequency of use.[96] Further oral drugs are under investigation, one being laquinimod, which was announced in August 2012 and is in a third phase III trial after mixed results in the previous ones.[97] Similarly, studies aimed to improve the efficacy and ease of use of already existing therapies are occurring. This includes the use of new preparations such as the PEGylated version of interferon-β-1a, which it is hoped may be given at less frequent doses with similar effects.[98][99] Request for approval ofpeginterferon beta-1a is expected during 2013.[99]

Monoclonal antibodies have also raised high levels of interest. Alemtuzumab, daclizumab and CD20 monoclonal antibodies such as rituximab, ocrelizumab and ofatumumab have all shown some benefit and are under study as potential treatments.[69] Their use has also been accompanied by the appearance of potentially dangerous adverse effects, most importantly opportunistic infections.[96] Related to these investigations is the development of a test for JC virusantibodies which might help to predict who is at greater risk of developing progressive multifocal leukoencephalopathy when taking natalizumab.[96] While monoclonal antibodies will probabaly have some role in the treatment of the disease in the future, it is believed that it will be small due to the risks associated to them.[96]

Another research strategy is to evaluate the combined effectiveness of two or more drugs.[100] The main rationale for polytherapy in MS is that the involved treatments target different mechanisms of the disease and therefore their use is not necessarily exclusive.[100]bMoreover synergies, in which a drug potentiates the effect of another are also possible. Nevertheless there can also appear important drawbacks such as antagonizing mechanisms of action or potentiation of deleterious secondary effects.[100] While there have been several clinical trials of combined therapy none has shown positive enough effects to merit the consideration as a viable treatment for MS.[100]

Neuroprotective and specially regenerative treatments, such as stem cell therapy, while their research is considered of high importance at the moment they are only a promise of future therapeutic approaches.[101] Likewise, there are not any effective treatments for the progressive variants of the disease. Many of the newest drugs as well as those under development are probably going to be evaluated as therapies for PPMS or SPMS, and their improved effectiveness when compared with previously existing drugs may eventually lead to a positive result in these groups of patients.[96]

Disease biomarkers

MRI brain scan produced using a Gradient-echo phase sequence showing an iron deposite in a white matter lesion (inside green box in the middle of the image; enhanced and marked by red arrow top-left corner).[102]

While diagnostic criteria are not expected to change in the near future, work to develop biomarkers that aid diagnosis and prediction of disease evolution is ongoing.[96] New diagnostic methods that are being investigated include work with anti-myelin antibodies, and studies with serum and cerebrospinal fluid but none of them has yielded reliably positive results.[103]

Currently there are no laboratory investigations that can predict prognosis. Several promising approaches have been proposed including: interleukin-6, nitric oxide and nitric oxide synthase, osteopontin, and fetuin-A.[103] Since disease progression is the result of degeneration of neurons the roles of proteins showing loss of nerve tissue such as neurofilaments, tau and N-acetylaspartate are under investigation.[103] Other effects include looking for biomarkers that distinguish between those who will and will not respond to medications.[103]

Improvement in neuroimaging techniques such as positron emission tomography (PET) or magnetic resonance imaging (MRI) carry a promise for better diagnosis and prognosis predictions, although the effect of such improvements in daily medical practice may take several decades.[96] Regarding MRI, there several techniques that have already shown some usefulness in research settings and could be introduced into clinical practice, such as double-inversion recovery sequences, magnetization transfer, diffusion tensor, and functional magnetic resonance imaging.[104] These techniques have a higher specificity than existing ones, but still lack some standarization of acquisition protocols and the creation of normative values.[104] There are other techniques under development that include contrast agents capable of measuring levels of peripheral macrophages, inflammation, or neuronal dysfunction.[104] And techniques that measure iron deposition that could serve to determine the role of this feature in MS, or that of cerebral perfusion.[104] Similary new PET radiotracers might serve as markers of altered processes such as brain inflammation, cortical pathology, apoptosis, or remylienation.[105]

Chronic cerebrospinal venous insufficiency

Main article: Chronic cerebrospinal venous insufficiency

In 2008, vascular surgeon Paolo Zamboni suggested that MS involves constrictions of veins draining the brain which he referred to as chronic cerebrospinal venous insufficiency (CCSVI). He found CCSVI in all patients with MS in his study, performed a surgical procedure, later called in the media the "liberation procedure" to correct it and claimed that 73% of participants improved.[106] This theory received significant attention in the media and among MS patients, especially in Canada.[107] Concerns have been raised with Zamboni's research as it was neither blinded nor controlled, and its assumptions about the underlying cause of the disease is not backed by known data.[108] Also further studies have either not found a similar relationship or found one which is much less strong one,[109] raising serious objections to the hypothesis.[110] The "liberation procedure" has been criticized for resulting in serious complications and deaths with unproven benefits.[108] It is thus as of 2013 not recommended for the treatment of MS.[111] Additional research investigating the CCSVI hypothesis are underway.[112]

See also

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Further reading

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