SERPINB1
Template:PBB Leukocyte elastase inhibitor (LEI) also known as serpin B1 is a protein that in humans is encoded by the SERPINB1 gene. It is a member of the clade B serpins or ov-serpins (ovalbumin related serpins) founded by ovalbumin.[1][2] [3]
MNEI (murine neutrophil elastase inhibitor) is the mouse orthologue of human SerpinB1.
Function
SerpinB1 is a serine protease inhibitor found in granules of polymorphonuclear neutrophils. It inhibits among other serine proteases the neutrophil elastase, PR3 and cathepsin G, all found in neutrophil granules, by a suicide inhibition mechanism. SerpinB1 was found to reduce tissue damage caused by the mentioned proteases during inflammation and has a role in neutrophil homeostasis in mice. In various infection models (e.g. pneumonia) correlation of SerpinB1 absence and lack of microbial clearance have been shown. Different knockout strains serve as model to investigate the role of SerpinB1 in vivo.[3][4] [5]
See also
References
- ^ Remold-O'Donnell E, Chin J, Alberts M (1992). "Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor". Proc Natl Acad Sci U S A. 89 (12): 5635–9. doi:10.1073/pnas.89.12.5635. PMC 49347. PMID 1376927.
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ignored (help)CS1 maint: multiple names: authors list (link) - ^ "Entrez Gene: SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1".
- ^ a b SerpinB1 a clade B serpin or ov-serpin. Cite error: The named reference "test" was defined multiple times with different content (see the help page).
- ^ SerpinB1 protects neutrophil reserves in bone marrow.
- ^ SerpinB1 preserves lung defense functions.
Further reading
External links
- The MEROPS online database for peptidases and their inhibitors: I04.006
- SERPINB1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.