SERPINI1

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SERPINI1
Protein SERPINI1 PDB 1jjo.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SERPINI1, PI12, neuroserpin, serpin family I member 1
External IDs MGI: 1194506 HomoloGene: 21045 GeneCards: SERPINI1
RNA expression pattern
PBB GE SERPINI1 205352 at fs.png
More reference expression data
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005025
NM_001122752

NM_009250

RefSeq (protein)

NP_001116224
NP_005016

NP_033276.1
NP_033276

Location (UCSC) Chr 3: 167.74 – 167.83 Mb Chr 3: 75.56 – 75.64 Mb
PubMed search [1] [2]
Wikidata
View/Edit Human View/Edit Mouse

Neuroserpin is a protein that in humans is encoded by the SERPINI1 gene.[3]

It is associated with Familial encephalopathy with neuroserpin inclusion bodies.

Serine protease inhibitors of the serpin superfamily are involved in many cellular processes. Neuroserpin was first identified as a protein secreted from the axons of dorsal root ganglion neurons (Stoeckli et al., 1989). It is expressed in the late stages of neurogenesis during the process of synapse formation.[supplied by OMIM][3]

Interactions[edit]

SERPINI1 has been shown to interact with Tissue plasminogen activator.[4]

References[edit]

  1. ^ "Human PubMed Reference:". 
  2. ^ "Mouse PubMed Reference:". 
  3. ^ a b "Entrez Gene: SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1". 
  4. ^ Parmar, Parmjeet K; Coates Leigh C; Pearson John F; Hill Rena M; Birch Nigel P (September 2002). "Neuroserpin regulates neurite outgrowth in nerve growth factor-treated PC12 cells". J. Neurochem. England. 82 (6): 1406–15. doi:10.1046/j.1471-4159.2002.01100.x. ISSN 0022-3042. PMID 12354288. 

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: I04.025