SERPINI1

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SERPINI1
Protein SERPINI1 PDB 1jjo.png
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesSERPINI1, PI12, neuroserpin, serpin family I member 1
External IDsOMIM: 602445 MGI: 1194506 HomoloGene: 21045 GeneCards: SERPINI1
Gene location (Human)
Chromosome 3 (human)
Chr.Chromosome 3 (human)[1]
Chromosome 3 (human)
Genomic location for SERPINI1
Genomic location for SERPINI1
Band3q26.1Start167,735,243 bp[1]
End167,825,568 bp[1]
RNA expression pattern
PBB GE SERPINI1 205352 at fs.png
More reference expression data
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005025
NM_001122752

NM_009250
NM_001357514

RefSeq (protein)

NP_001116224
NP_005016

NP_033276
NP_001344443

Location (UCSC)Chr 3: 167.74 – 167.83 MbChr 3: 75.56 – 75.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Neuroserpin is a protein that in humans is encoded by the SERPINI1 gene.[5]

It is associated with Familial encephalopathy with neuroserpin inclusion bodies.

Serine protease inhibitors of the serpin superfamily are involved in many cellular processes. Neuroserpin was first identified as a protein secreted from the axons of dorsal root ganglion neurons (Stoeckli et al., 1989). It is expressed in the late stages of neurogenesis during the process of synapse formation.[supplied by OMIM][5]

Interactions[edit]

SERPINI1 has been shown to interact with Tissue plasminogen activator.[6]

References[edit]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163536 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027834 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1".
  6. ^ Parmar, Parmjeet K; Coates Leigh C; Pearson John F; Hill Rena M; Birch Nigel P (September 2002). "Neuroserpin regulates neurite outgrowth in nerve growth factor-treated PC12 cells". J. Neurochem. 82 (6): 1406–15. doi:10.1046/j.1471-4159.2002.01100.x. ISSN 0022-3042. PMID 12354288.

Further reading[edit]

External links[edit]

  • The MEROPS online database for peptidases and their inhibitors: I04.025