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SERPINB1

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Template:PBB Leukocyte elastase inhibitor (LEI) also known as serpin B1 is a protein that in humans is encoded by the SERPINB1 gene. It is a member of the clade B serpins or ov-serpins (ovalbumin related serpins) founded by ovalbumin.[1][2] [3]

MNEI (murine neutrophil elastase inhibitor) is the mouse orthologue of human SerpinB1. </ref> [3]

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Function

SerpinB1 is a serine protease inhibitor found in granules of polymorphonuclear neutrophils. It inhibits among other serine proteases the neutrophil elastase, PR3 and cathepsin G, all found in neutrophil granules, by a suicide inhibition mechanism. SerpinB1 was found to reduce tissue damage caused by the mentioned proteases during inflammation and has a role in neutrophil homeostasis in mice. In various infection models (e.g. pneumonia) correlation of SerpinB1 absence and lack of microbial clearance have been shown. Different knockout strains serve as model to investigate the role of SerpinB1 in vivo.[4][5] [6]

See also

References

  1. ^ Remold-O'Donnell E, Chin J, Alberts M (1992). "Sequence and molecular characterization of human monocyte/neutrophil elastase inhibitor". Proc Natl Acad Sci U S A. 89 (12): 5635–9. doi:10.1073/pnas.89.12.5635. PMC 49347. PMID 1376927. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  2. ^ "Entrez Gene: SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1".
  3. ^ a b SerpinB1 a clade B serpin or ov-serpin.
  4. ^ SerpinB1 function in regulating inflammation.
  5. ^ SerpinB1 protects neutrophil reserves in bone marrow.
  6. ^ SerpinB1 preserves lung defense functions.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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