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Talk:History and culture of substituted amphetamines

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This is an old revision of this page, as edited by 173.228.54.200 (talk) at 19:00, 27 November 2014 (→‎Neurotoxicity). The present address (URL) is a permanent link to this revision, which may differ significantly from the current revision.

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Title

Presenting information as this article does is a new concept on Wikipedia and I like it but please continue to seek feedback from WP:WikiProject Medicine and other interested communities about this. This could set a good precedent.

I think that the title of the article should be History of amphetamine. Wikipedia titles are generally succinct. Remember that the title will eventually be translated when the article is and cultural emphases like "history, society, and culture" may not translate as well as something more general and simple. Blue Rasberry (talk) 14:05, 16 September 2013 (UTC)[reply]

Thanks for the feedback. :)
I completely agree on the title - I think my first choice is way too long; I chose a tentative name to get the split done since I wanted to create the proposal to split/merge similar content from methamphetamine to this article. I've posted a proposal about the methamphetamine split on both Wikipedia Talk:WikiProject Medicine and Wikipedia Talk:WikiProject Pharmacology. I don't know of any wikiprojects that work on cultural and/or historical articles analogous to this one though. Seppi333 (talk) 15:40, 16 September 2013 (UTC)[reply]
Additionally, per WP:TITLEFORMAT, the title of this article should not be in title case; it should be in sentence case. Right now, as Amphetamine: History, Society, and Culture, it reads as though it's the title of a book. Flyer22 (talk) 03:37, 27 September 2013 (UTC)[reply]
I agree - I unfortunately read the MOS on title conventions after I made the first split into this article. I'm going to propose renaming the page soon - I just need to work out a content issue for this and methamphetamine with another editor on talk:methamphetamine#Retrieved chemical sections first. Regards, Seppi333 (talk) 16:24, 27 September 2013 (UTC)[reply]

Scope

This article should combine cultural aspects of amphetamine use and use of related or derivative drugs like methamphetamine, because I do think that these drugs are connected with a common culture. It would be great to identify sources which make this connection. Blue Rasberry (talk) 14:09, 16 September 2013 (UTC)[reply]

Are amphetamine and methamphetamine really synonymous? This article mixes the two compounds together in a manner that implies as much. Yet, in para. 1, it is noted that meth is neurotoxic but amphetamines are not. (Without explaining the difference.) Further, in street terms it would seem the two drugs have fairly divergent histories. As such, mixing them as is done here does not help present the topic with much clarity.

Also, based on my and others' comments, in terms of organization, having the term "meth" disambiguate to the chemstry/pharmacology page instead of to something more like this page is a huge disservice to readers. Most will be put off by the heavy-duty chemistry AND are not intereted in it particularly anyhow. At present, the "methamphetamine" article does NOT link to this age in any readily useful way (say at or near the TOP of that article. This oversight MUST be fixed to avoid losing more readers and rendering Wikipeia irrelevant. My two cents, thx. Cynthisa (talk) 09:44, 6 February 2014 (UTC)[reply]

I've been meaning to merge more of the history/culture sections of the most notable substituted amphetamine articles (which is basically just MDMA/ecstasy and the subst. amph page itself), but I haven't finished copyediting this page after the last merge. A bit of disorganization is expected in light of that. Nonetheless, the plan was to illustrate the common elements in subst. amphetamine culture with this page. Seppi333 (Insert 2¢ | Maintained) 17:06, 6 February 2014 (UTC)[reply]

Neurotoxicity

Found the claim to be unsupported by source. A claim of marginally less neurotoxicity than methamphetamine is a sensible extrapolation, but source does not indicate zero neurotoxicity. Flying Hamster (talk) 11:53, 14 August 2014 (UTC)[reply]

The source says it's not directly toxic. That means not directly toxic... Seppi333 (Insert 2¢ | Maintained) 19:04, 14 August 2014 (UTC)[reply]

I agree with Flying Hamster that the below statements about amphetamine are not supported by the quotes in the references (the meth statments may be ok, but I haven't looked closely):

There is strong evidence that methamphetamine is directly neurotoxic to dopaminergic and serotonergic neurons.[1] Very high doses of amphetamine can cause neurotoxicity, but this is entirely due to oxidative stress rather than direct neurotoxicity;[2][3] in other words, unlike methamphetamine, amphetamine itself is not neurotoxic to humans.[2]


The article seems to be making a potentially WP:OR argument that amphetamine is safer/less toxic than methamphetamine, but the quotes in references are only about meth. It is concerning to me that a cultural/historical article focuses on the toxicity of approved prescription drugs. It seems off-topic and potentially anti-medicine since lot of people take these medically with little choice. In any case, I am not sure why these theories of amp vs meth differences are important to state at the beginning of this article. I agree they should be moved and properly referenced or deleted. 173.228.54.200 (talk) 18:55, 27 November 2014 (UTC)[reply]

  1. ^ Krasnova, IN; Cadet, JL (May 2009). "Methamphetamine toxicity and messengers of death". Brain Research Reviews. 60 (2): 379–407. doi:10.1016/j.brainresrev.2009.03.002. PMC 2731235. PMID 19328213.
  2. ^ a b Malenka RC, Nestler EJ, Hyman SE (2009). "15". In Sydor A, Brown RY (ed.). Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (2nd ed.). New York: McGraw-Hill Medical. p. 370. ISBN 9780071481274. Unlike cocaine and amphetamine, methamphetamine is directly toxic to midbrain dopamine neurons.{{cite book}}: CS1 maint: multiple names: authors list (link)
  3. ^ Millichap, J. Gordon (2009). "Medications for ADHD". Attention Deficit Hyperactivity Disorder Handbook: A Physician's Guide to ADHD. Springer. pp. 111–42. ISBN 978-1-4419-1397-5. {{cite book}}: External link in |chapterurl= (help); Unknown parameter |chapterurl= ignored (|chapter-url= suggested) (help)
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