|Millennium:||1st millennium BC|
|Centuries:||4th century BC – 3rd century BC – 2nd century BC|
|Decades:||280s BC 270s BC 260s BC – 250s BC – 240s BC 230s BC 220s BC|
|Years:||253 BC 252 BC 251 BC – 250 BC – 249 BC 248 BC 247 BC|
|250 BC by topic|
|State leaders – Sovereign states|
|Birth and death categories|
|Births – Deaths|
|Establishments and disestablishments categories|
|Establishments – Disestablishments|
|Gregorian calendar||250 BC|
|Ab urbe condita||504|
|Bahá'í calendar||−2093 – −2092|
|English Regnal year||N/A|
|Chinese calendar||庚戌年 (Metal Dog)
2447 or 2387
— to —
辛亥年 (Metal Pig)
2448 or 2388
|Coptic calendar||−533 – −532|
|Ethiopian calendar||−257 – −256|
|- Vikram Samvat||−193 – −192|
|- Shaka Samvat||N/A|
|- Kali Yuga||2852–2853|
|Igbo calendar||−1249 – −1248|
|Iranian calendar||871 BP – 870 BP|
|Islamic calendar||898 BH – 897 BH|
|Minguo calendar||2161 before ROC
|Thai solar calendar||294|
|Wikimedia Commons has media related to 250 BC.|
Year 250 BC was a year of the pre-Julian Roman calendar. At the time it was known as the Year of the Consulship of Regulus and Longus (or, less frequently, year 504 Ab urbe condita). The denomination 250 BC for this year has been used since the early medieval period, when the Anno Domini calendar era became the prevalent method in Europe for naming years.
- Ptolemy II encourages the Jewish residents of Alexandria to have their Bible translated into Greek. Because around seventy translators are used to achieve this, the translation is known as the Septuagint.
- Following the death of the King of Cyrene, Magas, Queen Apama II, Magas' widow, and Antigonus II arrange the marriage of Antigonus' half-brother Demetrius the Fair to Berenice of Cyrene, daughter of Magas and Apama. However, when Demetrius the Fair arrives, Apama becomes his lover. In response, Berenice leads an uprising in which Demetrius is killed in Apama's bedroom.
- In the Punic War, the Romans shift their attention to the southwest of Sicily. They send a naval expedition toward the Carthaginian city of Lilybaeum. En route, the Romans seize and burn the Carthaginian held cities of Selinous and Heraclea Minoa. The Romans then begin the siege of Lilybaeum.
- According to tradition (Horace, Odes, iii. 5), after the defeat of the Carthaginians at the Battle of Panormus, the Carthaginians release Marcus Atilius Regulus from prison and he is sent to Rome on parole to negotiate a peace or an exchange of prisoners. However, on his arrival, he strongly urges the Roman Senate to refuse both proposals and continue fighting. He then honours his parole by returning to Carthage where he is executed by being placed in a spiked barrel, which is then let roll down a hill.
- Andragoras, a Seleucid satrap of the province of Partahia (Parthia), tries to gain independence from the Seleucid Kingdom under Antiochus II.
- According to the Theravāda commentaries and chronicles, the Third Buddhist Council is convened by the Mauryan king Ashoka at Pataliputra (modern Patna), under the leadership of the monk Moggaliputta Tissa. Its objective is to purify the Buddhist movement, particularly from opportunistic factions which are being attracted by the royal patronage.
- The Mauryan sculpture Didarganj Yakshi holding a Fly Whisk, from Patna, Bihar in India, is made (approximate date). It is now kept at the Patna Museum in Patna.
- The Mauryan Lion Capital of Asoka, is erected as part of a pillar at Sarnath, Uttar Pradesh in India (approximate date). It is now preserved at the Sarnath Museum in Sarnath.
- Marcus Atilius Regulus, Roman general and consul (executed)
- Timaeus, Greek historian who has studied rhetoric under a pupil of Isocrates (b. c. 345 BC)
- Erasistratus, Greek anatomist and royal physician under Seleucus I Nicator of Syria. He has founded a school of anatomy in Alexandria (b. 310 BC)