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3-Hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase

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3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase
Identifiers
EC no.1.14.14.12
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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NCBIproteins

3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase (EC 1.14.14.12, HsaA) is an enzyme with systematic name 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione,FMNH2:oxygen oxidoreductase.[1] This enzyme catalyses the following chemical reaction:

3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H2O

This bacterial enzyme participates in the degradation of several steroids, including cholesterol and testosterone.

References

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  1. ^ Dresen C, Lin LY, D'Angelo I, Tocheva EI, Strynadka N, Eltis LD (July 2010). "A flavin-dependent monooxygenase from Mycobacterium tuberculosis involved in cholesterol catabolism". The Journal of Biological Chemistry. 285 (29): 22264–75. doi:10.1074/jbc.M109.099028. PMC 2903365. PMID 20448045.
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