Jump to content

4-(Gamma-L-glutamylamino)butanoyl-(BtrI acyl-carrier protein) monooxygenase

From Wikipedia, the free encyclopedia
4-(gamma-L-glutamylamino)butanoyl-(BtrI acyl-carrier protein) monooxygenase
Identifiers
EC no.1.14.14.13
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Search
PMCarticles
PubMedarticles
NCBIproteins

4-(gamma-L-glutamylamino)butanoyl-(BtrI acyl-carrier protein) monooxygenase (EC 1.14.14.13, btrO (gene)) is an enzyme with systematic name 4-(gamma-L-glutamylamino)butanoyl-(BtrI acyl-carrier protein),FMN:oxygen oxidoreductase (2-hydroxylating).[1] This enzyme catalyses the following chemical reaction

4-(gamma-L-glutamylamino)butanoyl-[BtrI acyl-carrier protein] + FMNH2 + O2 4-(gamma-L-glutamylamino)-(2S)-2-hydroxybutanoyl-[BtrI acyl-carrier protein] + FMN + H2O

4-(gamma-L-glutamylamino)butanoyl-(BtrI acyl-carrier protein) monooxygenase catalyses a step in the biosynthesis of the side chain of the aminoglycoside antibiotics of the butirosin family.

References

[edit]
  1. ^ Li Y, Llewellyn NM, Giri R, Huang F, Spencer JB (June 2005). "Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway". Chemistry & Biology. 12 (6): 665–75. doi:10.1016/j.chembiol.2005.04.010. PMID 15975512.
[edit]