FMO4

FMO4
Identifiers
Aliases	FMO4, FMO2, flavin containing monooxygenase 4, flavin containing dimethylaniline monoxygenase 4
External IDs	OMIM: 136131; MGI: 2429497; HomoloGene: 68219; GeneCards: FMO4; OMA:FMO4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1q24.3 Start 171,314,183 bp End 171,342,084 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1 H2.1|1 70.34 cM Start 162,620,757 bp End 162,641,541 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney tubule right lobe of liver mucosa of ileum gonad human kidney testicle glomerulus metanephric glomerulus ascending aorta Descending thoracic aorta Top expressed in right kidney yolk sac jejunum proximal tubule zygote duodenum embryo ileum secondary oocyte human kidney More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 2329 226564 Ensembl ENSG00000076258 ENSMUSG00000026692 UniProt P31512 Q8VHG0 RefSeq (mRNA) NM_002022 NM_144878 RefSeq (protein) NP_002013 NP_659127 Location (UCSC) Chr 1: 171.31 – 171.34 Mb Chr 1: 162.62 – 162.64 Mb PubMed search
Wikidata
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Dimethylaniline monooxygenase [N-oxide-forming] 4 is an enzyme that in humans is encoded by the FMO4 gene.

Function

Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting in fish odor syndrome Trimethylaminuria. Three forms of the enzyme, FMO1 found in fetal liver, FMO2 found in adult liver, and FMO3 are encoded by genes clustered in the 1q23-q25 region. Flavin-containing monooxygenases are NADPH-dependent flavoenzymes that catalyzes the oxidation of soft nucleophilic heteroatom centers in drugs, pesticides, and xenobiotics.

Cancer

FMO4 gene has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. For this reason, FMO4 is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression.

Further reading

• Hines RN, Cashman JR, Philpot RM, Williams DE, Ziegler DM (1994). "The mammalian flavin-containing monooxygenases: molecular characterization and regulation of expression". Toxicol. Appl. Pharmacol. 125 (1): 1–6. doi:10.1006/taap.1994.1042. PMID 8128486.
• Dolphin CT, Shephard EA, Povey S, Smith RL, Phillips IR (1992). "Cloning, primary sequence and chromosomal localization of human FMO2, a new member of the flavin-containing mono-oxygenase family". Biochem. J. 287 ( Pt 1) (Pt 1): 261–7. doi:10.1042/bj2870261. PMC 1133153. PMID 1417778.
• Phillips IR, Dolphin CT, Clair P, Hadley MR, Hutt AJ, McCombie RR, Smith RL, Shephard EA (1995). "The molecular biology of the flavin-containing monooxygenases of man". Chem. Biol. Interact. 96 (1): 17–32. doi:10.1016/0009-2797(94)03580-2. PMID 7720101.
• Itagaki K, Carver GT, Philpot RM (1996). "Expression and characterization of a modified flavin-containing monooxygenase 4 from humans". J. Biol. Chem. 271 (33): 20102–7. doi:10.1074/jbc.271.33.20102. PMID 8702731.
• Janmohamed A, Dolphin CT, Phillips IR, Shephard EA (2001). "Quantification and cellular localization of expression in human skin of genes encoding flavin-containing monooxygenases and cytochromes P450". Biochem. Pharmacol. 62 (6): 777–86. doi:10.1016/S0006-2952(01)00718-3. PMID 11551524.
• Furnes B, Feng J, Sommer SS, Schlenk D (2003). "Identification of novel variants of the flavin-containing monooxygenase gene family in African Americans". Drug Metab. Dispos. 31 (2): 187–93. doi:10.1124/dmd.31.2.187. PMID 12527699. S2CID 6619389.